Article
Agriculture, Dairy & Animal Science
Barbara U. Metzler-Zebeli, Frederike Lerch, Fitra Yosi, Julia Voetterl, Juliane Ehmig, Simone Koger, Doris Verhovsek
Summary: This study aimed to investigate the development of the gut microbiome in piglets. The collection of feces revealed that feeding method and fecal characteristics influenced the composition of the microbiome. The results showed that age and feeding method were major factors affecting the microbiome, and fecal characteristics should also be considered.
Article
Agriculture, Dairy & Animal Science
Lijun Shang, Junyan Zhou, Jiayu Tu, Xiangfang Zeng, Shiyan Qiao
Summary: Research has shown that supplementation with Microcin C7 (C7) can improve growth performance and reduce diarrhea rates in weaned piglets. The selective regulation of specific microbial taxa by C7 contributes to its diarrhea-alleviating effects. The optimal dosage range for C7 is 250-500 mg/kg, with supplementation of 5000 mg/kg showing no adverse effects on any parameters, making it a safe alternative to antibiotic growth promoters.
Article
Agriculture, Dairy & Animal Science
Yanyan Song, Yong Luo, Bing Yu, Jun He, Ping Zheng, Xiangbing Mao, Zhiqing Huang, Junqiu Luo, Yuheng Luo, Hui Yan, Quyuan Wang, Huifen Wang, Daiwen Chen, Jie Yu
Summary: The study evaluated the effects of tannic acid on growth performance, diarrhea rate, nutrient digestibility, and intestinal health in weaned piglets. Results showed that appropriate supplementation of tannic acid can prevent post-weaning diarrhea and improve intestinal health of piglets.
Article
Agriculture, Dairy & Animal Science
Shuangbo Huang, Zhijuan Cui, Xiangyu Hao, Chuanhui Cheng, Jianzhao Chen, Deyuan Wu, Hefeng Luo, Jinping Deng, Chengquan Tan
Summary: This study investigated the hydration properties of different-source fibrous materials and their effects on growth performance, nutrient digestibility, diarrhea, and intestinal health in weaned piglets. The results showed that different fibers varied in their hydration properties and had different impacts on diarrhea, microbial composition, and SCFAs production. Fiber hydration properties were positively correlated with in vitro SCFAs production, while diarrhea index and nutrient digestibility were negatively and positively correlated with SCFAs levels in the colon contents of weaned piglets, respectively.
JOURNAL OF ANIMAL SCIENCE AND BIOTECHNOLOGY
(2022)
Article
Microbiology
Can Yang, Min Wang, XiaoWu Tang, HuanSheng Yang, FengNa Li, YanCan Wang, Jianzhong Li, YuLong Yin
Summary: The study found that compared to a diet high in amylose or amylopectin, a diet with a DAR of 0.40 resulted in more severe diarrhea in weaning piglets. However, after the microbes and metabolites are regulated by DAR, intestinal health will improve.
FRONTIERS IN MICROBIOLOGY
(2021)
Article
Veterinary Sciences
Frederike Lerch, Fitra Yosi, Julia C. Voetterl, Simone Koger, Juliane Ehmig, Suchitra Sharma, Doris Verhovsek, Barbara U. Metzler-Zebeli
Summary: Little information is available on age- and creep-feeding-related microbial and immune development in neonatal piglets. This study investigated the effects of age and creep feeding on the microbiome, metabolites, histomorphology, and gene expression related to microbial signaling, immune function, and barrier function in suckling and newly weaned piglets. The results showed that age mainly influenced the composition of gastric and cecal microbiome, while creep feeding had a smaller effect. Weaning significantly altered the microbial communities and gene expression related to microbial signaling and immunity. Weaning also impaired barrier function and stimulated antimicrobial secretion.
FRONTIERS IN VETERINARY SCIENCE
(2023)
Article
Agriculture, Dairy & Animal Science
Frederike Lerch, Julia C. Voetterl, Heidi E. Schwartz-Zimmermann, Elena L. Sassu, Lukas Schwarz, Rene Renzhammer, Moritz Buenger, Suchitra Sharma, Simone Koger, Arife Sener-Aydemir, Narciso M. Quijada, Evelyne Selberherr, Stefan Kummer, Franz Berthiller, Barbara U. Metzler-Zebeli
Summary: This study evaluated the immediate effect of exposing the jejunal and colonic mucosa to a plant-based microbiome on the mucosal structure, secretory response, and permeability in piglets before and after weaning. The results showed that the plant-based microbiome stimulated the host's secretory response, altered the gut structure, and decreased epithelial integrity, with effects being less strong postweaning.
JOURNAL OF ANIMAL SCIENCE
(2022)
Article
Agriculture, Dairy & Animal Science
Julia C. Voetterl, Frederike Lerch, Heidi E. Schwartz-Zimmermann, Elena L. Sassu, Lukas Schwarz, Rene Renzhammer, Moritz Buenger, Simone Koger, Suchitra Sharma, Arife Sener-Aydemir, Narciso M. Quijada, Evelyne Selberherr, Franz Berthiller, Barbara U. Metzler-Zebeli
Summary: After weaning, piglets often experience gut inflammation and reduced performance. The plant-based diet, lack of sow milk, and changes in gut microbiome and metabolite composition may contribute to these symptoms. However, the immediate response of the gut mucosa to these changes is not well understood.
JOURNAL OF ANIMAL SCIENCE
(2023)
Article
Veterinary Sciences
Wanting Dong, Ning Ding, Yu Zhang, Zhen Tan, Xiangdong Ding, Qin Zhang, Li Jiang
Summary: The study revealed that PEDV infection alters the microbial communities in both jejunal content and jejunal mucosa, with Lactobacillus salivarius showing a protective effect against PEDV infection in IPEC-J2 cells.
FRONTIERS IN VETERINARY SCIENCE
(2021)
Article
Biochemical Research Methods
David M. Ribeiro, Catia F. Martins, Josipa Kules, Anita Horvatic, Nicolas Guillemin, Joao P. B. Freire, P. David Eckersall, Andre M. Almeida, Jose A. M. Prates
Summary: This study assessed the impact of Spirulina and lysozyme supplementation on piglet muscle proteome, revealing increased glycogen metabolism and nutrient reserves utilization in Spirulina group, and enhanced structural muscle protein synthesis with higher energy requirements in SP + L group. Proteomics offers valuable insight into the effects of dietary microalgae and enzyme activity on piglet metabolism.
JOURNAL OF PROTEOMICS
(2021)
Article
Veterinary Sciences
Sabrina Becker, Anna Maier, Saskia Peters, Kathrin Buettner, Gerald Reiner
Summary: Neither the use of S-ketamine nor intranasal administration can be suitable alternatives for the anaesthesia of male suckling piglets for castration.
BMC VETERINARY RESEARCH
(2021)
Article
Biochemical Research Methods
Martin Beaumont, Laurent Cauquil, Allan Bertide, Ingrid Ahn, Celine Barilly, Lisa Gil, Cecile Canlet, Olivier Zemb, Geraldine Pascal, Arnaud Samson, Sylvie Combes
Summary: The gut microbiota produces different metabolites in suckling and weaned piglets, including short-chain fatty acids and biogenic amines. The origin of the piglets also impacts the levels of certain bacterial metabolites. The fecal metabolome signatures in suckling and weaned piglets are associated with specific microbiota-predicted functionalities, structure, and diversity.
JOURNAL OF PROTEOME RESEARCH
(2021)
Article
Microbiology
Shiyu Tao, Huicong Zou, Jingjing Li, Hong Wei
Summary: This study provides a comprehensive understanding of the intestinal virome in early-weaned piglets, revealing the differences in virome profiles between healthy piglets and piglets with diarrhea. Potential biomarkers for diarrhea in early-weaned piglets were identified, laying the foundation for the development of strategies to prevent and treat early-weaning-induced piglet diarrhea.
MICROBIOLOGY SPECTRUM
(2022)
Article
Veterinary Sciences
Joris Michiels, Damien Truffin, Maryam Majdeddin, Mario Van Poucke, Elout Van Liefferinge, Noemie Van Noten, Mario Vandaele, Celine Van Kerschaver, Jeroen Degroote, Luc Peelman, Pierre Linder
Summary: This study found that feeding pigs gluconic acid during the weaning period can improve their growth and gut health, potentially alleviating the growth-check experienced after weaning. This effect may be mediated through changes in gut microbiota composition and fermentation.
PORCINE HEALTH MANAGEMENT
(2023)
Article
Cell Biology
Malen Massot-Cladera, Maria del Mar Rigo-Adrover, Laura Herrero, Angels Franch, Margarida Castell, Jelena Vulevic, Francisco J. Perez-Cano, Maria J. Rodriguez Lagunas
Summary: B-GOS supplementation can reduce the incidence and severity of rotavirus-associated diarrhea and influence the immune response against rotavirus infections.
Article
Biochemistry & Molecular Biology
Matthias Dierick, Daisy Vanrompay, Bert Devriendt, Eric Cox
Summary: Lactoferrin is a multifunctional protein that not only exhibits antimicrobial activity, but also modulates host defense in various ways. Therefore, lactoferrin has the potential to be an alternative to antibiotics.
BIOCHEMISTRY AND CELL BIOLOGY
(2021)
Article
Biotechnology & Applied Microbiology
F. Engelen, D. Thiry, B. Devleesschauwer, M. Heyndrickx, J. Mainil, L. De Zutter, E. Cox
Summary: The study found that young dairy calves are important reservoirs of potentially pathogenic E. coli O157 and O26 on farms, with most isolates possessing high pathogenic potential to humans. However, calf diarrhoea could not be directly associated with the presence of E. coli O26.
JOURNAL OF APPLIED MICROBIOLOGY
(2021)
Article
Biotechnology & Applied Microbiology
F. Engelen, D. Thiry, B. Devleesschauwer, J. Mainil, L. De Zutter, E. Cox
Summary: This study found that 58% of Belgian dairy cattle farms tested positive for 'gang of five' STEC, with O26-STEC being the most frequently isolated. OVS collected from pens housing young cattle aged 1-24 months had a 35% positivity rate for STEC, indicating a higher likelihood of carrying STEC in this age category. Additionally, half of the obtained 'gang of five' STEC isolates (48%) possessed the eae and stx2 genes, suggesting a high pathogenic potential to humans.
LETTERS IN APPLIED MICROBIOLOGY
(2021)
Review
Immunology
Hans van der Weken, Eric Cox, Bert Devriendt
Summary: Oral vaccines are crucial for gut immunity, but face challenges due to the unique environment of the gastrointestinal tract, requiring strategies to overcome barriers and induce robust immune responses.
Article
Biochemistry & Molecular Biology
Martin Guilliams, Johnny Bonnardel, Birthe Haest, Bart Vanderborght, Camille Wagner, Anneleen Remmerie, Anna Bujko, Liesbet Martens, Tinne Thone, Robin Browaeys, Federico F. De Ponti, Bavo Vanneste, Christian Zwicker, Freya R. Svedberg, Tineke Vanhalewyn, Amanda Goncalves, Saskia Lippens, Bert Devriendt, Eric Cox, Giuliano Ferrero, Valerie Wittamer, Andy Willaert, Suzanne J. F. Kaptein, Johan Neyts, Kai Dallmeier, Peter Geldhof, Stijn Casaert, Bart Deplancke, Peter ten Dijke, Anne Hoorens, Aude Vanlander, Frederik Berrevoet, Yves Van Nieuwenhove, Yvan Saeys, Wouter Saelens, Hans Van Vlierberghe, Lindsey Devisscher, Charlotte L. Scott
Summary: This study presents a spatial proteogenomic atlas of the liver, combining multiple omics datasets, and reveals the cellular niches and transcriptomic identities of Kupffer cells and lipid-associated macrophages. It also demonstrates the inducibility of lipid-associated macrophages by local lipid exposure and the crucial role of ALK1-BMP9/10 axis in Kupffer cell development.
Article
Agriculture, Dairy & Animal Science
Kwangwook Kim, Yijie He, Cynthia Jinno, Lauren Kovanda, Xunde Li, David Bravo, Eric Cox, Yanhong Liu
Summary: The supplementation of Coligo in weaned pigs infected with ETEC showed similar effects to antibiotics in promoting growth, reducing diarrhea severity, and improving gut health.
JOURNAL OF ANIMAL SCIENCE AND BIOTECHNOLOGY
(2022)
Article
Biochemistry & Molecular Biology
Haixiu Wang, Eric Cox, Bert Devriendt
Summary: Enterotoxigenic Escherichia coli (ETEC) strains recognize and respond to factors secreted by gut epithelial cells, leading to transcriptional modulation of key ETEC virulence genes.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2022)
Meeting Abstract
Agriculture, Dairy & Animal Science
Kwangwook Kim, Yijie He, Cynthia N. Jinno, Lauren L. Kovanda, Xunde Li, David Bravo, Eric Cox, Yanhong Liu
JOURNAL OF ANIMAL SCIENCE
(2022)
Article
Pharmacology & Pharmacy
Matthias Dierick, Ruben Ongena, Daisy Vanrompay, Bert Devriendt, Eric Cox
Summary: Lactoferrin, as an alternative for antimicrobials, shows potential in preventing ETEC infections in pigs by reducing fluid secretion and colonization ability of ETEC.
Article
Green & Sustainable Science & Technology
Roberto Bonnelly, Ana Lidia Queiroz Cavalcante, Victor V. V. Calderon, Rafael Azevedo Barauna, Rommel Thiago Juca Ramos, Yaset Rodriguez-Rodriguez, Luis Enrique Rodriguez De Francisco, Luis Orlando Maroto Martin, Omar Paino Perdomo, Edian Franklin Franco De Los Santos
Summary: The spread and contamination of antimicrobial-resistant bacteria in water sources is a growing concern. This study analyzed surface water samples from the Ozama River in the Dominican Republic and found a high prevalence of antibiotic-resistant bacteria. Among the 76 isolates, over 30% were clinically relevant and 43% showed multidrug resistance. Understanding the danger of multidrug resistance in this area is important for human health.
Editorial Material
Veterinary Sciences
Mohamed Rhouma, Marie Archambault, Patrick Butaye
VETERINARY SCIENCES
(2023)
Article
Veterinary Sciences
Anne A. M. J. Becker, Stacie Munden, Evonne McCabe, Daniel Hurley, Seamus Fanning, Aspinas Chapwanya, Patrick Butaye
Summary: In order to achieve a consistent diagnosis, treatment, and prevention of uterine diseases in dairy cattle, researchers have focused on identifying the bacteria present in the uterus, known as the uterine microbiota. A study analyzed the uterine microbiota from healthy, pregnant, and diseased cows and found that the bacterial composition was more similar in healthy and pregnant cows compared to diseased animals. Endometritis, a major cause of infertility in dairy cows, results in significant economic losses. The study explored the endometrial microbiota and found significant differences in species diversity between healthy and diseased cows.
VETERINARY SCIENCES
(2023)
Review
Veterinary Sciences
Mohamed Rhouma, Leila Soufi, Schlasiva Cenatus, Marie Archambault, Patrick Butaye
Summary: Antimicrobial resistance is a global threat to human and animal health, with livestock potentially having a low contribution to the spread of resistance. Strategies targeting the reduction of all antimicrobials and implementation of the 'One Health' approach are recommended to effectively combat antimicrobial resistance.
VETERINARY SCIENCES
(2022)
Article
Veterinary Sciences
Audrey Habets, Fabrice Touzain, Pierrick Lucas, Nguyen Thi Thu Huong, Atsushi Iguchi, Florence Crombe, Nicolas Korsak, Denis Pierard, Marc Saulmont, Eric Cox, Frederik Engelen, Jacques Mainil, Damien Thiry
Summary: This study aimed to identify non-classical O serotypes of bovine enteropathogenic Escherichia coli (EPEC) and characterize their virulence profiles. The results showed that O177 was the most frequent serotype among EPEC from both diarrheic and healthy calves, while O156 was the most frequent in healthy cattle. The virulence gene profiles of bovine EPEC were closely related to other EPEC strains and AE-STEC strains with the same O:H serotypes. The study highlights the need for further research to identify more O:H serotypes of bovine EPEC and understand their evolution and relationship with AE-STEC.
VETERINARY SCIENCES
(2022)
Article
Veterinary Sciences
Michael Pelst, Clara Hoebart, Hilde de Rooster, Bert Devriendt, Eric Cox
Summary: Certain allergens, TLRL, IL-17A, and calcitriol have been found to modulate the secretion of CXCL8 in immortalized canine buccal epithelial cells.
VETERINARY RESEARCH
(2022)