期刊
ANNUAL REVIEW OF ANIMAL BIOSCIENCES, VOL 3
卷 3, 期 -, 页码 397-418出版社
ANNUAL REVIEWS
DOI: 10.1146/annurev-animal-022513-114152
关键词
cattle; African buffalo; CD8 T cell; antigenic diversity; immunodominance
类别
资金
- Biotechnology and Biological Sciences Research Council [BBS/E/D/20231762] Funding Source: researchfish
- Biotechnology and Biological Sciences Research Council [BB/H009515/1, BBS/E/D/05201234, BBS/E/D/05201236] Funding Source: Medline
- BBSRC [BBS/E/D/05201236, BBS/E/D/20231762, BBS/E/D/05201234, BB/H009515/1] Funding Source: UKRI
Infection with Theileria parva is asymptomatic in African buffalo but results in severe disease in cattle. Currently, vaccination relies on infection and treatment, using a mixture of three parasite isolates to overcome the strain specificity of immunity. Genotypic analyses of field populations of T. parva indicate a panmictic population structure, reflecting frequent sexual recombination. Profound immunodominance of protective CD8 T cell responses, together with polymorphism of the target antigens and frequent genetic recombination, contribute to the strain-restricted immunity. The dominant CD8 target antigens are highly polymorphic, but the live vaccine appears to contain limited diversity. A model to explain the ability of the vaccine to confer immunity against highly diverse field parasite challenge is discussed. Parasites in cattle exhibit much more limited antigenic diversity than parasites in buffalo, consistent with other evidence that the cattle-maintained population represents a subset of T. parva recently adapted to cattle.
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