期刊
TRENDS IN PHARMACOLOGICAL SCIENCES
卷 35, 期 8, 页码 397-403出版社
ELSEVIER SCIENCE LONDON
DOI: 10.1016/j.tips.2014.05.001
关键词
biomarker; connectivity; graph theory; neuroimaging; resting state; schizophrenia
资金
- NIDDK NIH HHS [R01 DK103691, R21 DK102052] Funding Source: Medline
- NIMH NIH HHS [T32 MH015442, R01 MH102224, F31 MH102879] Funding Source: Medline
Developing translational biomarkers is a priority for psychiatry research. Task-independent functional brain imaging is a relatively novel technique that allows examination of the brain's intrinsic networks, defined as functionally and (often) structurally connected populations of neurons whose properties reflect fundamental neurobiological organizational principles of the central nervous system. The ability to study the activity and organization of these networks has opened a promising new avenue for translational investigation, because they can be analogously examined across species and disease states. Interestingly, imaging studies have revealed shared spatial and functional characteristics of the intrinsic network architecture of the brain across species, including mice, rats, non-human primates, and humans. Using schizophrenia as an example, we show how intrinsic networks may show similar abnormalities in human diseases and animal models of these diseases, supporting their use as biomarkers in drug development.
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