Article
Biochemistry & Molecular Biology
Carina Hoering, Marcus Conrad, Christian A. Soldner, Jinan Wang, Heinrich Sticht, Andrea Strasser, Yinglong Miao
Summary: In this study, the coupling profiles of histamine receptors H2R and H4R to engineered mini-G proteins were investigated using cellular experimental assays and Gaussian accelerated molecular dynamics (GaMD) simulations. The results revealed that H2R and H4R preferentially bind to different types of G proteins, providing insights into the signaling mechanisms of histamine receptors.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2021)
Article
Multidisciplinary Sciences
Trygve E. Bakken, Nikolas L. Jorstad, Qiwen Hu, Blue B. Lake, Wei Tian, Brian E. Kalmbach, Megan Crow, Rebecca D. Hodge, Fenna M. Krienen, Staci A. Sorensen, Jeroen Eggermont, Zizhen Yao, Brian D. Aevermann, Andrew I. Aldridge, Anna Bartlett, Darren Bertagnolli, Tamara Casper, Rosa G. Castanon, Kirsten Crichton, Tanya L. Daigle, Rachel Dalley, Nick Dee, Nikolai Dembrow, Dinh Diep, Song-Lin Ding, Weixiu Dong, Rongxin Fang, Stephan Fischer, Melissa Goldman, Jeff Goldy, Lucas T. Graybuck, Brian R. Herb, Xiaomeng Hou, Jayaram Kancherla, Matthew Kroll, Kanan Lathia, Baldur van Lew, Yang Eric Li, Christine S. Liu, Hanqing Liu, Jacinta D. Lucero, Anup Mahurkar, Delissa McMillen, Jeremy A. Miller, Marmar Moussa, Joseph R. Nery, Philip R. Nicovich, Sheng-Yong Niu, Joshua Orvis, Julia K. Osteen, Scott Owen, Carter R. Palmer, Thanh Pham, Nongluk Plongthongkum, Olivier Poirion, Nora M. Reed, Christine Rimorin, Angeline Rivkin, William J. Romanow, Adriana E. Sedeno-Cortes, Kimberly Siletti, Saroja Somasundaram, Josef Sulc, Michael Tieu, Amy Torkelson, Herman Tung, Xinxin Wang, Fangming Xie, Anna Marie Yanny, Renee Zhang, Seth A. Ament, M. Margarit Behrens, Hector Corrada Bravo, Jerold Chun, Alexander Dobin, Jesse Gillis, Ronna Hertzano, Patrick R. Hof, Thomas Hollt, Gregory D. Horwitz, C. Dirk Keene, Peter Kharchenko, Andrew L. Ko, Boudewijn P. Lelieveldt, Chongyuan Luo, Eran A. Mukamel, Antonio Pinto-Duarte, Sebastian Preissl, Aviv Regev, Bing Ren, Richard H. Scheuermann, Kimberly Smith, William J. Spain, Owen R. White, Christof Koch, Michael Hawrylycz, Bosiljka Tasic, Evan Z. Macosko, Steven A. McCarroll, Jonathan T. Ting, Hongku Zeng, Kun Zhang, Guoping Feng, Joseph R. Ecker, Sten Linnarsson, Ed S. Lein
Summary: The research reveals a broadly conserved cellular makeup of the primary motor cortex in humans, marmoset monkeys, and mice, with species-specific specializations. Few cell-type marker genes are conserved across species, indicating some candidate genes and regulatory mechanisms responsible for functional identity of cell types and their species-specific adaptations.
Review
Biochemistry & Molecular Biology
Phuong Linh Nguyen, Jungsook Cho
Summary: Histamine and its receptors play important roles in cancer biology, promoting cancer development, growth, and metastasis through interactions with different HRs, and regulating immune cell infiltration with immunomodulatory function. Various HR ligands affect tumor progression in different cancer types, and HR subtype expression levels may serve as prognostic biomarkers in multiple cancers.
Article
Immunology
Chung-Chi Yang, Yen-Ling Hung, Hsin-Ju Li, Ya-Fan Lin, Su-Jane Wang, Der-Chen Chang, Chi-Ming Pu, Chi-Feng Hung
Summary: Quercetin has anti-inflammatory and anti-itching effects by reducing histamine-induced calcium influx via the TRPV1 channel and influencing H4 receptors, providing a molecular mechanism for its anti-itching, anti-inflammatory, and unpleasant sensations properties.
INTERNATIONAL IMMUNOPHARMACOLOGY
(2021)
Article
Biochemistry & Molecular Biology
Infant Sagayaraj Ravhe, Arunkumar Krishnan, Narayanan Manoj
Summary: This study uses phylogenetic and comparative genomics analyses to reveal the evolutionary history of histamine receptors, proposing a revised classification of the vertebrate H-3-H-4 receptor subtypes. It challenges the notion that H-4 is restricted to mammals and identifies a new H-3 subtype (H3B). The study also suggests that the ability of H-1, H-2, and H3-4 to bind histamine was acquired convergently.
MOLECULAR PHYLOGENETICS AND EVOLUTION
(2021)
Article
Pharmacology & Pharmacy
Joachim Neumann, Juliane M. Grobe, Jacqueline Weisgut, Hubert G. Schwelberger, Wieslawa Agnieszka Fogel, Margareta Marusakova, Hartmut Wache, Heike Baehe, Igor B. Buchwalow, Stefan Dhein, Britt Hofmann, Uwe Kirchhefer, Ulrich Gergs
Summary: This study explores the physiological role of histamine in the mouse and human heart, and demonstrates that inhibiting histamine-metabolizing enzymes can alter the beating rate and force of the human heart.
FRONTIERS IN PHARMACOLOGY
(2021)
Article
Immunology
Amit Kumar Thakur, Manni Luthra-Guptasarma
Summary: Ankylosing spondylitis (AS) is a type of spondyloarthropathy strongly associated with the genetic marker HLA-B27. This study investigates the differential disease association of two HLA-B27 subtypes, B*2704 and B*2709, and finds distinct protein clearance mechanisms involved in their degradation. These findings provide insights into the different pathogenic outcomes of these HLA-B27 subtypes.
FRONTIERS IN IMMUNOLOGY
(2022)
Review
Oncology
Xihua Mao, Chioma Omeogu, Shama Karanth, Ashwini Joshi, Clare Meernik, Lauren Wilson, Amy Clark, April Deveaux, Chunyan He, Tisha Johnson, Karen Barton, Samantha Kaplan, Tomi Akinyemiju
Summary: In this systematic review and meta-analysis, the associations between reproductive factors and breast cancer subtypes were summarized. The results showed that later age at menarche and breastfeeding were consistently associated with decreased risk of breast cancer across all subtypes. However, later age at menopause, later age of first childbirth, and nulliparity/low parity were associated with increased risk of specific subtypes. The use of oral contraceptives and hormone replacement therapy showed inconsistent associations with different subtypes. The findings can improve the customization of prevention strategies and the accuracy of risk stratification models.
Article
Pharmacology & Pharmacy
U. Gergs, J. Weisgut, K. Griethe, N. Misslinger, U. Kirchhefer, Joachim Neumann
Summary: The study found that overexpression of human H-2-histamine receptors in a mouse heart model can lead to arrhythmias, indicating that histamine has inotropic and chronotropic effects in H-2-TG but not in WT.
NAUNYN-SCHMIEDEBERGS ARCHIVES OF PHARMACOLOGY
(2021)
Article
Multidisciplinary Sciences
Ruixue Xia, Na Wang, Zhenmei Xu, Yang Lu, Jing Song, Anqi Zhang, Changyou Guo, Yuanzheng He
Summary: The authors used cryo-EM to determine the complex structure of histamine-bound H1R/Gq and proposed a mechanism for ligand-induced receptor activation, providing insights for designing novel antihistamines.
NATURE COMMUNICATIONS
(2021)
Article
Medicine, General & Internal
Fan Wu, Yi-Yun Yin, Wen-Hua Fan, You Zhai, Ming-Chen Yu, Di Wang, Chang-Qing Pan, Zheng Zhao, Guan-Zhang Li, Wei Zhanga
Summary: Through integrated analysis of transcriptome, genome, and methylome, two intrinsic molecular subtypes associated with distinct molecular characteristics and clinical outcomes were identified and validated. Oligo1 subtype was characterized by worse prognosis and enrichment of cell proliferation and Wnt signaling pathways, while Oligo2 subtype had a favorable outcome with increased activation of immune response and metabolic process. This classification serves as an independent prognostic factor in oligodendrogliomas, and its robustness was verified in validation cohorts.
Article
Biochemistry & Molecular Biology
Xiaoyuan Ma, Marta Arimont Segura, Barbara Zarzycka, Henry F. Vischer, Rob Leurs
Summary: The Exome Aggregation Consortium has collected the protein-encoding DNA sequences of almost 61,000 unrelated humans and identified 463 naturally occurring genetic missense variations in the histamine receptor family. The research analyzed the distribution of these variations in the four histamine receptor subtypes and selected four missense variants for further study regarding their impact on receptor activity.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2021)
Article
Immunology
Anette T. Hansen Selno, Vadim V. V. Sumbayev, Bernhard F. F. Gibbs
Summary: Basophils play a crucial role in allergies and Th2-driven diseases by releasing inflammatory and immunomodulatory mediators. The responsiveness of basophils to IgE-mediated activation may be regulated by the expression of SERCA2, a calcium-regulating protein. This study found an inverse correlation between SERCA2 expression and basophil responsiveness, suggesting that SERCA2 may be an additional regulator of basophil reactivity.
FRONTIERS IN IMMUNOLOGY
(2023)
Article
Virology
Jungang Chen, Jiao Song, Karlie Plaisance-Bonstaff, Shengyu Mu, Steven R. Post, Lu Dai, Zhiqiang Qin
Summary: Although KSHV has been found to cause various human cancers, including KS and PEL, the mechanisms of KSHV-induced tumorigenesis and virus-host interaction network are still not fully understood. Histamine, and its receptors, have been shown to play a role in allergic diseases. Previous data showed that histamine receptor antagonists can effectively inhibit KSHV replication. In this study, histamine treatment was found to promote cell proliferation and growth abilities of KSHV-infected cells, and affect the expression of inflammatory factors.
Review
Pharmacology & Pharmacy
Lin Yang, Yi Wang, Zhong Chen
Summary: Epilepsy is a common neurological disorder characterized by recurrent seizures that are not well controlled by current medication. Recent research has shown that histamine in the central nervous system plays a crucial role in modulating neural excitability and epilepsy pathogenesis. Studies are now focusing on the potential of histamine receptors in controlling and treating epilepsy.
BRITISH JOURNAL OF PHARMACOLOGY
(2022)
Article
Pharmacology & Pharmacy
Stefan Berrisch, Jessica Ostermeyer, Volkhard Kaever, Solveig Kaelble, Denise Hilfiker-Kleiner, Roland Seifert, Erich H. Schneider
NAUNYN-SCHMIEDEBERGS ARCHIVES OF PHARMACOLOGY
(2017)
Editorial Material
Pharmacology & Pharmacy
Erich H. Schneider
NAUNYN-SCHMIEDEBERGS ARCHIVES OF PHARMACOLOGY
(2017)
Article
Pharmacology & Pharmacy
Eva J. Wunschel, Bastian Schirmer, Roland Seifert, Detlef Neumann
FRONTIERS IN PHARMACOLOGY
(2017)
Article
Immunology
Bastian Schirmer, Luisa Bringmann, Roland Seifert, Detlef Neumann
FRONTIERS IN IMMUNOLOGY
(2018)
Article
Pharmacology & Pharmacy
Bastian Schirmer, Luisa Lindemann, Kaya Saskia Bittkau, Rukijat Isaev, Daniela Boesche, Malte Juchem, Roland Seifert, Detlef Neumann
JOURNAL OF PHARMACOLOGY AND EXPERIMENTAL THERAPEUTICS
(2020)
Article
Geriatrics & Gerontology
Domiziana Costamagna, Robin Duelen, Fabio Penna, Detlef Neumann, Paola Costelli, Maurilio Sampaolesi
JOURNAL OF CACHEXIA SARCOPENIA AND MUSCLE
(2020)
Article
Oncology
Bastian Schirmer, Tamina Rother, Inga Bruesch, Andre Bleich, Christopher Werlein, Danny Jonigk, Roland Seifert, Detlef Neumann
Review
Biochemistry & Molecular Biology
Bastian Schirmer, Detlef Neumann
Summary: Histamine is a versatile mediator involved in various physiological processes, including the regulation of inflammation. Approved compounds targeting histamine receptors are used for allergic inflammation, gastric acid reduction, and narcolepsy treatment. H4R ligands are still under investigation for inflammatory diseases, showing moderate effects so far.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2021)
Editorial Material
Pharmacology & Pharmacy
Detlef Neumann, Roland Seifert
NAUNYN-SCHMIEDEBERGS ARCHIVES OF PHARMACOLOGY
(2021)
Article
Pharmacology & Pharmacy
Jasper Carsten Schrammel, Martin Koenig, Miriam Frommer, Kaya Saskia Andersen, Marla Kirsten, Roland Seifert, Detlef Neumann, Bastian Schirmer
Summary: By studying cell lines, it was found that colon epithelial cells have functional expression of H4 receptors, which further confirmed the involvement of H4 receptors in inflammatory bowel disease and associated colon cancer. However, the transferability of these data to humans is uncertain. The expression of histamine receptor subtypes varied among different cell lines, and genetic modification is necessary for detailed functional analysis in human colon-derived cell lines.
NAUNYN-SCHMIEDEBERGS ARCHIVES OF PHARMACOLOGY
(2023)
Meeting Abstract
Cell Biology
T. Rother, B. Schirmer, R. Seifert, D. Neumann
INFLAMMATION RESEARCH
(2019)
Meeting Abstract
Pharmacology & Pharmacy
T. Rother, B. Schirmer, R. Seifert, D. Neumann
NAUNYN-SCHMIEDEBERGS ARCHIVES OF PHARMACOLOGY
(2019)
Meeting Abstract
Cell Biology
D. Neumann
INFLAMMATION RESEARCH
(2018)
Meeting Abstract
Pharmacology & Pharmacy
D. Neumann, E. Wunschel, B. Schirmer
NAUNYN-SCHMIEDEBERGS ARCHIVES OF PHARMACOLOGY
(2017)
Meeting Abstract
Pharmacology & Pharmacy
K. Bittkau, L. Bringmann, D. Boesche, R. Isaev, B. Schirmer, R. Seifert, D. Neumann
NAUNYN-SCHMIEDEBERGS ARCHIVES OF PHARMACOLOGY
(2018)