Review
Biochemistry & Molecular Biology
Veronica Ruta, Vittoria Pagliarini, Claudio Sette
Summary: This review explores how signal transduction pathways regulate factors involved in RNA processing events and highlights the impact of various post-translational modifications on RNA-binding proteins. It also illustrates examples of how common signal transduction pathways can modulate biological processes through changes in RNA processing regulation.
Review
Biochemistry & Molecular Biology
Hong Jin, Li Zhang, Jun He, Min Wu, Li Jia, Jiabin Guo
Summary: Oxidative stress is a key mechanism in liver damage caused by various chemicals. The transcription factor FOXO3a plays a critical role in regulating redox imbalance, with its activity closely regulated by multiple post-translational changes and epigenetic processes. Depending on the chemical nature and subcellular context, the activation of FOXO3a by oxidative stress can induce multiple transcriptional programs that are crucial in liver oxidative injury.
Article
Biology
Amy Louise Ball, Carol E. Jolly, Mark G. Lennon, Jonathan J. Lyon, Ana Alfirevic, Amy E. Chadwick
Summary: This study describes the generation of transmitochondrial cybrids containing different mitochondrial genotypes to investigate the impact of mtDNA variation on mitochondrial function and susceptibility to drug-induced liver injury. The results show that different mitochondrial haplogroups have varying responses to mitotoxic drugs, suggesting that inter-individual variation in mitochondrial haplogroup may be a factor in determining sensitivity to mitochondrial toxicants.
Review
Medicine, Research & Experimental
Yu Liu, Zi-wei Guo, Jian Li, Ai-hong Li, Tao-guang Huo
Summary: The paper investigates the critical role of NLRP3 inflammasome in liver injury and discusses the impact of abnormal mitochondrial function on its activation. It also explores the advantages of natural products as potential therapeutic agents for liver injury.
BIOMEDICINE & PHARMACOTHERAPY
(2022)
Review
Biochemistry & Molecular Biology
Sen Zhang, Sijing Rao, Meiwen Yang, Chen Ma, Fengfang Hong, Shulong Yang
Summary: Hepatic ischemia-reperfusion injury is a major cause of post-operative hepatic dysfunction and liver failure after transplantation. Mitochondrial pathways play a crucial role in hepatic cell apoptosis, depending on multiple factors.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2022)
Review
Cell Biology
Julie Massart, Karima Begriche, Jessica H. Hartman, Bernard Fromenty
Summary: CYP2E1 plays a pivotal role in hepatotoxicity induced by alcohol abuse and different xenobiotics, generating reactive metabolites that induce oxidative stress, mitochondrial dysfunction, and cell death. Increased CYP2E1 activity in nonalcoholic fatty liver disease (NAFLD) leads to reactive oxygen species overproduction, triggering oxidative stress, necroinflammation, and fibrosis. Mitochondrial CYP2E1 (mtCYP2E1) has been found in different experimental models and may contribute to alcohol-associated liver disease, xenobiotic-induced hepatotoxicity, and NAFLD.
Review
Biochemistry & Molecular Biology
Sarah Parisi, Carlo Finelli, Antonietta Fazio, Alessia De Stefano, Sara Mongiorgi, Stefano Ratti, Alessandra Cappellini, Anna Maria Billi, Lucio Cocco, Matilde Y. Follo, Lucia Manzoli
Summary: Regulation of erythropoiesis is crucial in normal physiology and in diseases such as myelodysplastic syndromes and beta-thalassemia. Various signaling pathways, including those involving transforming growth factor-beta and erythropoietin, play key roles in this process. Phospholipase C and phosphatidylinositol 3-kinase are emerging as important therapeutic targets, and the erythropoiesis stimulating agent Roxadustat is showing promise in clinical development.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2021)
Article
Infectious Diseases
Dan Lei, Linlin Cao, Tairan Zhong, Qing-Yu He, Xuesong Sun
Summary: In this study, the researchers found that the mutation of the key residue Lys219 leads to a conformational change in CpxR, resulting in loss of its regulatory ability in antibiotic resistance.
JOURNAL OF ANTIMICROBIAL CHEMOTHERAPY
(2023)
Article
Gastroenterology & Hepatology
Raymond Kwan, Lu Chen, Min-Jung Park, Zemin Su, Sujith V. W. Weerasinghe, William M. Lee, Valerie L. Durkalski-Mauldin, Robert J. Fontana, M. Bishr Omary
Summary: The study found that serum CPS1 levels can be used as a potential prognostic biomarker in acetaminophen-induced acute liver failure (ALF), improving the accuracy of the ALFSG Prognostic Index in predicting 21-day transplant-free survival.
CLINICAL GASTROENTEROLOGY AND HEPATOLOGY
(2023)
Review
Pharmacology & Pharmacy
Andy Tran, Wenyuan He, Jim T. C. Chen, Denise D. Belsham
Summary: This review discusses the involvement of spexin in the hypothalamic control of energy homeostasis and reproduction, as well as the disorders and treatments related to energy homeostasis and reproduction that alter spexin expression. The review also explores the biochemical basis of spexin, its interaction with its cognate receptors, and the potential for developing therapeutics for energy homeostasis and reproductive disorders.
PHARMACOLOGY & THERAPEUTICS
(2022)
Article
Gastroenterology & Hepatology
Katerina Roma, Salman Mohammed, Blake Sieck, Katrina Naik, Shahid Wahid
Summary: Alternative medicine supplements, such as kratoms, have become a significant cause of liver injury in the US. Reports of adverse events linked to kratom use are increasing, including liver injury, organ dysfunction, and even death. The need for increased regulation and public awareness of the risks associated with kratom is emphasized.
JOURNAL OF HEPATOLOGY
(2023)
Article
Pharmacology & Pharmacy
Jisoo Song, Jiyeon Ham, Taeyeon Hong, Gwonhwa Song, Whasun Lim
Summary: Fraxetin extracted from Fraxinus rhynchophylla shows anticancer effects in hepatocellular carcinoma (HCC) cells by inhibiting cell proliferation, inducing apoptosis, and disrupting cellular environments. It has the potential to be a therapeutic agent against HCC progression.
Review
Pharmacology & Pharmacy
Binghui Jin, Guangyao Li, Lin Zhou, Zhe Fan
Summary: This paper outlines the signal pathways and cytokines involved in acute liver injury induced by intestinal I/R, providing new ideas for the prevention and treatment of liver injury caused by reperfusion after intestinal I/R.
FRONTIERS IN PHARMACOLOGY
(2022)
Article
Chemistry, Analytical
Manchang Kou, Kun Wang, Xinfeng Zhang, Xiang Cui, Wanchao Zhang, Baoyan Wang, Xiaoliang Tang, Weisheng Liu
Summary: In this study, a peroxynitrite-activable mitochondriatargeted phosphorescent chemodosimeter was developed for drug-induced liver injury monitoring. This chemodosimeter exhibited excellent turn-on phosphorescent response in the presence of peroxynitrite, and could visualize the generation of peroxynitrite in cells. This work provides a practical tool for further research on the pathogenesis of drug-induced liver injury.
SENSORS AND ACTUATORS B-CHEMICAL
(2023)
Article
Neurosciences
Diana J. Goode, Derek C. Molliver
Summary: This study identifies a mechanism for regulating mitochondrial function by Epac2 in DRG sensory neurons, contributing to acute inflammatory hyperalgesia in male mice. Systemic administration of the cyclooxygenase 2 inhibitor celecoxib can suppress Pdha1 phosphorylation in male DRG, thereby alleviating PGE2-induced heat hyperalgesia.
JOURNAL OF NEUROSCIENCE
(2021)
Letter
Gastroenterology & Hepatology
Brian T. Lee, Yun Wang, Alexander Yang, Hyosun Han, Liyun Yuan, John Donovan, Neil Kaplowitz, Gary Kanel, Jeffrey Kahn, Lily Dara
CLINICAL GASTROENTEROLOGY AND HEPATOLOGY
(2021)
Article
Medicine, General & Internal
Zobair M. Younossi, Vlad Ratziu, Rohit Loomba, Mary Rinella, Quentin M. Anstee, Zachary Goodman, Pierre Bedossa, Andreas Geier, Susanne Beckebaum, Philip N. Newsome, David Sheridan, Muhammad Y. Sheikh, James Trotter, Whitfield Knapple, Eric Lawitz, Manal F. Abdelmalek, Kris V. Kowdley, Aldo J. Montano-Loza, Jerome Boursier, Philippe Mathurin, Elisabetta Bugianesi, Giuseppe Mazzella, Antonio Olveira, Helena Cortez-Pinto, Isabel Graupera, David Orr, Lise Lotte Gluud, Jean-Francois Dufour, David Shapiro, Jason Campagna, Luna Zaru, Leigh MacConell, Reshma Shringarpure, Stephen Harrison, Arun J. Sanyal
Article
Gastroenterology & Hepatology
Brian T. Lee, Alexander H. Yang, Seth Urban, Ki-Yoon Kim, Ramon Ter-Oganesyan, Liyun Yuan, Hyosun H. Han, Saro Khemichian, Jeffrey A. Kahn, Brian Kim
Summary: The MELD score and MELD-Na score showed no significant difference in predicting post-TIPS outcomes, despite a higher delta MELD in patients with refractory ascites. The decision to pursue TIPS should be based on the original MELD score, as the MELD-Na score alone may exclude patients who could benefit from the procedure.
EUROPEAN JOURNAL OF GASTROENTEROLOGY & HEPATOLOGY
(2021)
Editorial Material
Gastroenterology & Hepatology
Liyun Yuan, Norah A. Terrrault
HEPATOBILIARY SURGERY AND NUTRITION
(2020)
Review
Biochemistry & Molecular Biology
Layla Shojaie, Andrea Iorga, Lily Dara
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2020)
Article
Gastroenterology & Hepatology
Kali Zhou, Jennifer L. Dodge, Liyun Yuan, Norah A. Terrault
Summary: Racial/ethnic differences exist in metabolic risk factors associated with liver steatosis and fibrosis, with Blacks showing a distinct metabolic phenotype for steatosis. Waist circumference and diabetes are consistently associated with increased risk of both steatosis and fibrosis, while there are variations in risk profiles among different racial/ethnic groups.
DIGESTIVE DISEASES AND SCIENCES
(2022)
Review
Gastroenterology & Hepatology
Brian T. Lee, Michele M. Tana, Jeffrey A. Kahn, Lily Dara
Summary: Autoimmune liver diseases in racial and ethnic minorities, such as Black and Latinx patients, are characterized by increased prevalence, later stage presentation, poor response to standard therapy, and transplant-related disparities. While genetic predispositions may explain some disparities, definitive genetic variations underlying these differences in outcomes are yet to be defined. Socioeconomic status, access to healthcare, environmental factors, and implicit provider bias can all contribute to poor patient outcomes.
Letter
Gastroenterology & Hepatology
Kali Zhou, Courtney L. Hanlon, Selena Zhou, Jennifer L. Dodge, Yong K. Kwon, Liyun Yuan
LIVER TRANSPLANTATION
(2021)
Article
Gastroenterology & Hepatology
Liyun Yuan, Courtney L. Hanlon, Norah Terrault, Saleh Alqahtani, Hani Tamim, Michelle Lai, Behnam Saberi
Summary: Since 2004, the number of liver transplants for NASH patients has significantly increased across all regions, but there are substantial differences in the proportion of HCC and post-transplant survival among different regions.
AMERICAN JOURNAL OF GASTROENTEROLOGY
(2022)
Review
Pharmacology & Pharmacy
Layla Shojaie, Myra Ali, Andrea Iorga, Lily Dara
Summary: Immune checkpoint inhibitors have revolutionized cancer therapy but can lead to immune-related adverse events affecting organs like the liver. The liver's high tolerance to foreign antigens can result in liver injury in a proportion of patients when immune checkpoints are blocked.
ACTA PHARMACEUTICA SINICA B
(2021)
Editorial Material
Gastroenterology & Hepatology
Lily Dara
Article
Gastroenterology & Hepatology
Thu Anne Mai, Divya Ayyala-Somayajula, Jasleen Singh, David Braxton, Leanna Wise, Liyun Yuan
ACG CASE REPORTS JOURNAL
(2022)
Letter
Gastroenterology & Hepatology
Liyun Yuan, Kyle S. McCommis, Brent A. Neuschwander-Tetri
HEPATOLOGY COMMUNICATIONS
(2022)
Meeting Abstract
Gastroenterology & Hepatology
Brian T. Lee, Jeffrey Kahn, Yun Wang, Liyun Yuan, Hyosun Han, Neil Kaplowitz, Gary Kanel, John Donovan, Lily Dara