期刊
TRENDS IN PHARMACOLOGICAL SCIENCES
卷 33, 期 1, 页码 28-34出版社
ELSEVIER SCIENCE LONDON
DOI: 10.1016/j.tips.2011.09.002
关键词
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资金
- National Institutes of Health [R01GM076167]
- National Natural Science Foundation of China [30971309]
- NATIONAL INSTITUTE OF GENERAL MEDICAL SCIENCES [R01GM076167] Funding Source: NIH RePORTER
The physiological functions of heterotrimeric G protein-coupled receptors (GPCRs) are dictated by their intracellular trafficking and precise targeting to the functional destinations. Over the past decades, most studies on the trafficking of GPCRs have focused on the events involved in endocytosis and recycling. By contrast, the molecular mechanisms underlying anterograde transport of newly synthesized GPCRs from the endoplasmic reticulum (ER) to the cell surface have only now begun to be revealed. In this review we discuss current advances in understanding the role of Ras-like GTPases, specifically the Rab and Sar1/ARF subfamilies, in regulating cell-surface transport of GPCRs en route from the ER and the Golgi.
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