Review
Medicine, Research & Experimental
Soudeh Ghafouri-Fard, Zahra Bahroudi, Hamed Shoorei, Atefe Abak, Maliheh Ahin, Mohammad Taheri
Summary: miR-140 is associated with a wide range of pathologies including cancer, and has roles in regulating immune-related targets, cell proliferation, and apoptosis. Its expression quantity can be used to predict clinical outcomes in cancer patients.
BIOMEDICINE & PHARMACOTHERAPY
(2021)
Review
Biochemistry & Molecular Biology
Yijie Wang, Fenfang Hong, Shulong Yang
Summary: Brain ischemia and reperfusion (I/R) is a severe manifestation of ischemic stroke. Accumulating evidence suggests that nitric oxide (NO) plays a crucial role in the pathological processes of brain I/R, including neuronal cell death and blood-brain barrier disruption. This review focuses on the role of endogenous NO in brain I/R and discusses therapeutic approaches associated with NO.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2022)
Article
Neurosciences
Xin Sui, Hideyuki Yoshioka, Yuichiro Fukumoto, Kazuya Kanemaru, Hiroyuki Kinouchi
Summary: HAX-1 is a mitochondrial protein that plays a neuroprotective role against ischemic neuronal injury, and the downregulation of HAX-1 by NOX2-produced ROS can induce apoptosis after cerebral ischemia.
EXPERIMENTAL NEUROLOGY
(2021)
Review
Cell Biology
Chengpeng Yu, Dean Rao, Tiantian Wang, Jia Song, Lei Zhang, Wenjie Huang
Summary: As a member of the TRIM protein family, TRIM27 is an important protein that plays multiple roles in regulating cellular processes under physiological and pathological conditions. It is implicated in the development of various diseases, particularly cancer and other human diseases. However, there is still limited understanding of TRIM27, and further investigations are needed.
FRONTIERS IN CELL AND DEVELOPMENTAL BIOLOGY
(2022)
Article
Plant Sciences
Varsha Meena, Shivani Sharma, Gazaldeep Kaur, Bhupinder Singh, Ajay Kumar Pandey
Summary: The major facilitator superfamily (MFS) is a group of secondary transporters found in all kingdoms of life, and zinc-induced facilitator-like (ZIFL) transporters are a subset of this family. They have been shown to play important roles in various plant species, such as transporting secondary metabolites and maintaining auxin homeostasis. The functions of ZIFL proteins highlight their significance in crop species.
Article
Computer Science, Artificial Intelligence
Wencheng Qin, Baojin Huang, Pinzhong Qin, Zhiyong Huang, Daidi Zhong
Summary: This paper proposes a two-stage attention network, WDC-Net, for person re-identification. It focuses on enhancing the connection between local features and extracting robust feature representations. Experimental results show that the proposed method achieves competitive performance on large-scale datasets and performs well on challenging datasets.
IMAGE AND VISION COMPUTING
(2022)
Review
Biochemistry & Molecular Biology
Yutaka Koyama
Summary: Reactive astrocytes are commonly observed in brain disorders and their involvement in the pathogenesis has led to the investigation of therapeutic strategies targeting astrocytic function. The upregulation of endothelin B (ETB) receptors in reactive astrocytes promotes their activation and has been reported to improve various brain disorders in animal models. The activation of astrocytic ETB receptors is seen as a promising drug target for the treatment of brain disorders.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2021)
Review
Immunology
Ayan Mohamud Yusuf, Nina Hagemann, Peter Ludewig, Matthias Gunzer, Dirk M. Hermann
Summary: Polymorphonuclear neutrophils (PMNs) exacerbate stroke injury by releasing reactive oxygen species, proteases, and proinflammatory cytokines after ischemic stroke. PMNs may also contribute to reperfusion deficits by obstructing brain capillaries. However, clinical studies targeting PMN brain infiltration did not improve stroke outcome.
FRONTIERS IN IMMUNOLOGY
(2022)
Review
Geriatrics & Gerontology
Ziyu Lu, Yuanmin Li
Summary: The determination of erythrocyte lifespan is crucial in diagnosing hemolytic diseases. Recent studies have found changes in erythrocyte lifespan in patients with various cardiovascular diseases, such as atherosclerotic coronary heart disease, hypertension, and heart failure. This review provides an overview of the research progress on erythrocyte lifespan in cardiovascular diseases.
Review
Food Science & Technology
Siyu Liu, Lu Cheng, Yanan Liu, Shengnan Zhan, Zufang Wu, Xin Zhang
Summary: Cognitive, mood, and sleep disorders are common and difficult to treat central nervous system disorders that significantly impact the lives of affected individuals. The gut-brain axis, which facilitates bidirectional information exchange between the gut microbiota and the nervous system, plays a vital role in the study of neurological disorders like neurodegenerative diseases. Dietary polyphenols have garnered attention due to their biological activity, diverse sources, structural variability, and low toxicity. Increasing the intake of dietary polyphenols is an emerging strategy for improving circadian rhythms and treating metabolic disorders by modulating the gut-brain axis.
Review
Cell Biology
Benedict Nathaniel, Penny A. F. Whiley, Yoichi Miyamoto, Kate L. Loveland
Summary: Regulated nucleocytoplasmic transport is crucial for changes in gene expression during cellular development and homeostasis. This paper provides an overview of the functions of importin proteins, with a focus on their roles in testis development and spermatogenesis.
SEMINARS IN CELL & DEVELOPMENTAL BIOLOGY
(2022)
Review
Oncology
Mohamed Bendellaa, Pierre Lelievre, Jean-Luc Coll, Lucie Sancey, Aurelien Deniaud, Benoit Busser
Summary: Zinc is a crucial element involved in various cellular processes and dysregulation of zinc homeostasis occurs in certain cancers. This review explores the role of zinc in cancer, including its related proteins as potential biomarkers and the use of zinc-based strategies for tumor treatment. Targeting zinc and its pathways offers therapeutic approaches, while direct utilization of zinc as a therapeutic agent holds promise for improving cancer prognosis.
INTERNATIONAL JOURNAL OF CANCER
(2023)
Review
Cell Biology
Emma Wilkinson, Yan-Hong Cui, Yu-Ying He
Summary: Chemical modifications of RNA molecules, mediated by writer, reader, and eraser proteins, regulate RNA metabolism and fate, impacting various cellular processes and disease development.
FRONTIERS IN CELL AND DEVELOPMENTAL BIOLOGY
(2022)
Review
Chemistry, Inorganic & Nuclear
Biplab K. Maiti, Jose J. G. Moura
Summary: Biological systems rely on proteins to house catalytic metal centers that drive essential assimilation and energy pathways. Imbalance in metal homeostasis, particularly copper overload, can lead to negative consequences like the progression of diseases. Anti-copper therapy, using copper-sequestering drugs like tetrathiomolybdate, shows promise in addressing health issues related to elevated copper levels, such as Wilson disease and cancer.
COORDINATION CHEMISTRY REVIEWS
(2021)
Review
Biochemistry & Molecular Biology
Dae Ki Hong, A. Ra Kho, Song Hee Lee, Beom Seok Kang, Min Kyu Park, Bo Young Choi, Sang Won Suh
Summary: Maintaining the correct ionic gradient is crucial for cellular homeostasis, and the TRP channel family and zinc play important roles in brain disease. Dysregulation of ionic gradients in diseases like ischemic stroke and traumatic brain injury leads to excessive release of zinc, causing cell damage. Regulating zinc homeostasis and blocking zinc translocation via TRP channels can protect against brain damage. These findings suggest that targeting zinc and TRP channels could be a potential strategy for treating brain diseases.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2023)
Article
Neurosciences
Yuliya V. Medvedeva, Sung G. Ji, Hong Z. Yin, John H. Weiss
JOURNAL OF NEUROSCIENCE
(2017)
Article
Neurosciences
Sung G. Ji, John H. Weiss
EXPERIMENTAL NEUROLOGY
(2018)
Review
Clinical Neurology
Sung G. Ji, Yuliya V. Medvedeva, Hwai-Lee Wang, Hong Z. Yin, John H. Weiss
Article
Neurosciences
Hong Z. Yin, John H. Weiss
Article
Oncology
Shengwen Calvin Li, Long T. Vu, Hector W. Ho, Hong Zhen Yin, Vic Keschrumrus, Qiang Lu, Jun Wang, Heying Zhang, Zhiwei Ma, Alexander Stover, John H. Weiss, Philip H. Schwartz, William G. Loudon
CANCER CELL INTERNATIONAL
(2012)
Article
Neurosciences
Hong Z. Yin, Cheng-I Hsu, Stephen Yu, Shyam D. Rao, Linda S. Sorkin, John H. Weiss
EXPERIMENTAL NEUROLOGY
(2012)
Article
Neurosciences
Hong Z. Yin, Stephen Yu, Cheng-I Hsu, Joe Liu, Allan Acab, Richard Wu, Anna Tao, Benjamin J. Chiang, John H. Weiss
EXPERIMENTAL NEUROLOGY
(2014)
Article
Biochemistry & Molecular Biology
Jiabin Guo, Sue P. Duckles, John H. Weiss, Xuejun Li, Diana N. Krause
FREE RADICAL BIOLOGY AND MEDICINE
(2012)
Article
Clinical Neurology
Angele Nalbandian, Katrina J. Llewellyn, Mallikarjun Badadani, Hong Z. Yin, Christopher Nguyen, Veeral Katheria, Giles Watts, Jogeshwar Mukherjee, Jouni Vesa, Vincent Caiozzo, Tahseen Mozaffar, John H. Weiss, Virginia E. Kimonis
Article
Neurosciences
Yuliya V. Medvedeva, John H. Weiss
NEUROBIOLOGY OF DISEASE
(2014)
Article
Multidisciplinary Sciences
Angele Nalbandian, Katrina J. Llewellyn, Masashi Kitazawa, Hong Z. Yin, Mallikarjun Badadani, Negar Khanlou, Robert Edwards, Christopher Nguyen, Jogeshwar Mukherjee, Tahseen Mozaffar, Giles Watts, John Weiss, Virginia E. Kimonis
Article
Multidisciplinary Sciences
Aaron Clausen, Taylor McClanahan, Sung G. Ji, John H. Weiss
Article
Cell Biology
H. Z. Yin, A. Nalbandian, C-I Hsu, S. Li, K. J. Llewellyn, T. Mozaffar, V. E. Kimonis, J. H. Weiss
CELL DEATH & DISEASE
(2012)
Article
Neurosciences
Sung G. Ji, Yuliya V. Medvedeva, John H. Weiss
EXPERIMENTAL NEUROLOGY
(2020)
Meeting Abstract
Biochemistry & Molecular Biology
James N. Horne, Diana N. Krause, Martin Kemper, Sue P. Duckles, John H. Weiss