Article
Plant Sciences
Martin Tannert, Gerd Ulrich Balcke, Alain Tissier, Margret Koeck
Summary: Phosphatidylcholine and phosphatidylethanolamine are the most abundant phospholipids in membranes, synthesized mainly via the Kennedy pathway. PECP1 in Arabidopsis regulates PCho synthesis by decreasing PEtn levels to avoid energy-consuming methylation. The gene At4g29530 is a putative PECP1 homolog with an unknown biological function, mainly expressed in leaves and flowers, and is not induced by phosphate starvation.
Article
Cell Biology
Andy B. Lam, Kirsten Kervin, Jessica E. Tanis
Summary: The study found that dietary vitamin B-12 can alleviate mitochondrial fragmentation, bioenergetic defects, and oxidative stress caused by Ab proteotoxicity, delaying the onset of the disease. Vitamin B-12 acts as a cofactor for methionine synthase, impacting the methionine/S-adenosylmethionine (SAMe) cycle, showing potential as a therapy to target pathogenic features of AD.
Editorial Material
Biochemistry & Molecular Biology
Tong Pan, Elizabeth A. Ronan, X. Z. Shawn Xu
Summary: A new study shows that the heat-sensing neuron AFD is responsible for attracting the parasitic nematode Strongyloides stercoralis to human body heat, using unknown neural mechanisms. Interestingly, this same neuron also plays a role in thermotaxis in the nematode C. elegans.
Article
Environmental Sciences
Rong Zhou, Ru Liu, Weixin Li, Yixuan Wang, Xiang Wan, Ninghui Song, Yue Yu, Jiaming Xu, Yuanqing Bu, Aiguo Zhang
Summary: The study revealed that the toxic effects of atrazine on Caenorhabditis elegans were concentration-dependent, leading to changes in body length, lifespan, intestinal ROS levels, locomotion behavior, and brood size. Additionally, atrazine may influence the biological activities of nematodes by modulating the mtUPR pathway.
Article
Environmental Sciences
Gefei Huang, Yiming Ma, Dongying Xie, Cunmin Zhao, Lin Zhu, Guangshan Xie, Pengfei Wu, Wei Wang, Zhongying Zhao, Zongwei Cai
Summary: Plastic pollution poses a significant threat to ecosystems. While the adverse effects of microplastics have been extensively studied, the toxicity of nanoplastics remains unclear, particularly at the protein level. This study used quantitative proteomics to investigate the proteome dynamics in a soil nematode exposed to 100 nm polystyrene nanoplastics (PS-NPs). The results showed that exposure to PS-NPs led to differential expression of proteins related to various cellular processes, and these changes were consistent with the observed phenotypic defects. Overall, this study provides insights into the molecular mechanisms underlying the toxicity of nanoplastics.
SCIENCE OF THE TOTAL ENVIRONMENT
(2023)
Article
Computer Science, Artificial Intelligence
Dan Su, Liangming Chen, Xiaohao Du, Mei Liu, Long Jin
Summary: The nematode connectome neural network (NCNN) is a modified convolutional neural network structure that uses the connectome of the nematode Caenorhabditis elegans as the connection pattern. It improves the accuracy and computational efficiency of image classification. Experimental results on multiple datasets demonstrate the effectiveness of the proposed NCNN model.
APPLIED SOFT COMPUTING
(2023)
Article
Agronomy
Satish Kumar Rajasekharan, Chaitany Jayprakash Raorane, Jintae Lee
Summary: This study presents a straightforward, rapid, eco-friendly, and efficient method for isolating nematode eggs and synchronizing nematode stages. The method involves using bacterial or fungal feed chunks to lure nematodes, and then gently washing the consumed feed to collect the eggs. The protocol proves to be a reliable, simple means of separating eggs from adults and inducing the synchronization of nematodes.
Article
Biochemical Research Methods
Nakul Sridhar, Apresio Kefin Fajrial, Rachel L. Doser, Frederic J. Hoerndli, Xiaoyun Ding
Summary: Caenorhabditis elegans is an important genetic model for neuroscience studies, but most studies are limited in obtaining both high-resolution microscopy imaging and behavior analysis in the same set of animals. In this paper, a novel microfluidic device using surface acoustic waves is presented to temporarily immobilize worms, allowing for non-invasive analysis of behavior and high-resolution imaging. This device enables longitudinal analysis of animal motility and subcellular morphological changes during development and aging.
Article
Chemistry, Medicinal
Haiyan Wu, Balakrishnan Prithiviraj, Zhijun Tan
Summary: This study evaluated the neurotoxicity and chronic toxicology of Saxitoxin (STX) on Caenorhabditis elegans. It found that STX does not cause lethal effects on the worms but does induce substantial oxidative stress, with a dose-responsive relationship. The lifespan, productivity, and body size of the worms were all influenced by STX exposure.
Article
Environmental Sciences
Sebastian Hoess, Marie-Theres Rauchschwalbe, Hendrik Fueser, Walter Traunspurger
Summary: The effects of 1-μm polystyrene (PS) beads on the reproduction of Caenorhabditis elegans in freshwater sediments were studied using a standardized protocol for toxicity testing. The results showed that the body burdens of PS beads in the nematodes differed between sediments, but not significantly. The ECx-values for C. elegans' reproduction varied among different sediments and were higher than values reported for water exposure, indicating that microplastic reduces food availability and affects reproduction in benthic ecosystems.
Article
Neurosciences
Adam J. Iliff, Can Wang, Elizabeth A. Ronan, Alison E. Hake, Yuling Guo, Xia Li, Xinxing Zhang, Maohua Zheng, Jianfeng Liu, Karl Grosh, R. Keith Duncan, X. Z. Shawn Xu
Summary: The ability to sense airborne sound extends beyond vertebrates and arthropods to include invertebrates as well, suggesting convergent evolution of auditory capabilities in the animal kingdom. The discovery challenges the conventional view that invertebrates are insensitive to sound and highlights the unexpected role of nAChRs in mechanosensation. Animals without ears should not be automatically presumed to be sound insensitive.
Article
Green & Sustainable Science & Technology
Carlos Lopez-Viso, Gassan Hodaifa, Manuel J. Munoz
Summary: This study discovered that Caenorhabditis elegans can grow on urban sludge and convert it into nematode biomass while removing organic matter. By conducting different experiments, the feasibility of using nematodes to reduce urban sludges was demonstrated. This work presents a new method for valorizing urban sludge and obtaining by-products with high added value.
JOURNAL OF CLEANER PRODUCTION
(2022)
Article
Environmental Sciences
Weiwei Sun, Han Liu, Aijun Qiao, Ting Jiang, Jianghui Li, Long Wang, Ling Yang, Huicong Huang, Xiumei Yan, Baolong Yan
Summary: The study found that certain environmental pollutants induce the accumulation of a specific protein in nematodes, forming "rod-like" structures that can be used to evaluate the toxicity of environmental contaminants. By generating transgenic nematodes, this monitoring method can be implemented more conveniently.
ENVIRONMENTAL TOXICOLOGY
(2023)
Editorial Material
Biochemistry & Molecular Biology
Patrick J. Hu
Summary: The study in C. elegans model showed that a conserved insulin-like signaling pathway plays an important role in shaping the phylogenetic composition of the gut microbiome.
Editorial Material
Biochemistry & Molecular Biology
Erin J. Cram
Summary: Cells release extracellular vesicles containing proteins, lipids, and RNAs to communicate with other cells and remove damaged components. In C. elegans, neuronal cells release large extracellular vesicles called exophers to clear damaged organelles and protein aggregates. Researchers have now shown that embryos in the uterus can stimulate body wall muscle cells to release exophers loaded with yolk, which are then absorbed by oocytes to nourish the next generation of embryos.
Article
Biochemistry & Molecular Biology
Soon Goo Lee, Ronald Nwumeh, Joseph M. Jez
JOURNAL OF BIOLOGICAL CHEMISTRY
(2016)
Article
Plant Sciences
Dieter Hackenberg, Michael R. McKain, Soon Goo Lee, Swarup Roy Choudhury, Tyler McCann, Spencer Schreier, Alex Harkess, J. Chris Pires, Gane Ka-Shu Wong, Joseph M. Jez, Elizabeth A. Kellogg, Sona Pandey
Article
Biochemistry & Molecular Biology
Soon Goo Lee, Joseph M. Jez
JOURNAL OF BIOLOGICAL CHEMISTRY
(2017)
Article
Biochemistry & Molecular Biology
Craig A. Schenck, Cynthia K. Holland, Matthew R. Schneider, Yusen Men, Soon Goo Lee, Joseph M. Jez, Hiroshi A. Maeda
NATURE CHEMICAL BIOLOGY
(2017)
Article
Chemistry, Medicinal
Alessandra Vallone, Sarah D'Alessandro, Simone Brogi, Margherita Brindisi, Giulia Chemi, Gloria Alfano, Stefania Lamponi, Soon Goo Lee, Joseph M. Jez, Karin J. M. Koolen, Koen J. Dechering, Simona Saponara, Fabio Fusi, Beatrice Gorelli, Donatella Taramelli, Silvia Parapini, Reto Caldelari, Giuseppe Campiani, Sandra Gemma, Stefania Butini
EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY
(2018)
Article
Microbiology
Sheri A. McClerklin, Soon Goo Lee, Christopher P. Harper, Ron Nwumeh, Joseph M. Jez, Barbara N. Kunkel
Article
Multidisciplinary Sciences
Rachel Fellows, Christopher M. Russo, Catarina S. Silva, Soon Goo Lee, Joseph M. Jez, John D. Chisholm, Chloe Zubieta, Max H. Nanao
SCIENTIFIC REPORTS
(2018)
Article
Biochemistry & Molecular Biology
Ashley M. Sherp, Soon Goo Lee, Evelyn Schraft, Joseph M. Jez
JOURNAL OF BIOLOGICAL CHEMISTRY
(2018)
Article
Biochemistry & Molecular Biology
Roshan Kumar, Soon Goo Lee, Rehna Augustine, Micheal Reichelt, Daniel G. Vassao, Manoj H. Palavalli, Aron Allen, Jonathan Gershenzon, Joseph M. Jez, Naveen C. Bisht
Article
Multidisciplinary Sciences
Soon Goo Lee, Eitan Salomon, Oliver Yu, Joseph M. Jez
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA
(2019)
Article
Biochemistry & Molecular Biology
Soon Goo Lee, Michelle S. Chung, Antea J. DeMarsilis, Cynthia K. Holland, Rohit Jaswaney, Cherry Jiang, Jakob H. P. Kroboth, Kevin Kulshrestha, Raymundo Z. W. Marcelo, Vidhya M. Meyyappa, Grant B. Nelson, Janki K. Patel, Alex J. Petronio, Samantha K. Powers, Peter R. Qin, Mythili Ramachandran, Divya Rayapati, John A. Rincon, Andreia Rocha, Joan Gabriel Rodinho Nunes Ferreira, Micah K. Steinbrecher, Kaisen Yao, Eric J. Zhang, Angela J. Zou, Margery Gang, Melanie Sparks, Barrie Cascella, Wilhelm Cruz, Joseph M. Jez
MOLECULAR AND BIOCHEMICAL PARASITOLOGY
(2020)
Article
Biochemistry & Molecular Biology
Soon Goo Lee, Kate Harline, Orchid Abar, Sakirat O. Akadri, Alexander G. Bastian, Hui-Yuan S. Chen, Michael Duan, Caroline M. Focht, Amanda R. Groziak, Jesse Kao, Jagdeesh S. Kottapalli, Matthew C. Leong, Joy J. Lin, Regina Liu, Joanna E. Luo, Christine M. Meyer, Albert F. Mo, Seong Ho Pahng, Vinay Penna, Chris D. Raciti, Abhinav Srinath, Shwetha Sudhakar, Joseph D. Tang, Brian R. Cox, Cynthia K. Holland, Barrie Cascella, Wilhelm Cruz, Sheri A. McClerkin, Barbara N. Kunkel, Joseph M. Jez
JOURNAL OF BIOLOGICAL CHEMISTRY
(2020)
Article
Microbiology
Rachel L. Edwards, Isabel Heueck, Soon Goo Lee, Ishaan T. Shah, Justin J. Miller, Andrew J. Jezewski, Marwa O. Mikati, Xu Wang, Robert C. Brothers, Kenneth M. Heidel, Damon M. Osbourn, Carey-Ann D. Burnham, Sophie Alvarez, Stephanie A. Fritz, Cynthia S. Dowd, Joseph M. Jez, Audrey R. Odom John
Article
Biochemistry & Molecular Biology
Kaleena Zhang, Josephine S. Lee, Regina Liu, Zita T. Chan, Trenton J. Dawson, Elisa S. De Togni, Chris T. Edwards, Isabel K. Eng, Ashley R. Gao, Luis A. Goicouria, Erin M. Hall, Kelly A. Hu, Katherine Huang, Alexander Kizhner, Kelsie C. Kodama, Andrew Z. Lin, Jennifer Y. Liu, Alan Y. Lu, Owen W. Peng, Erica P. Ryu, Sophia Shi, Maria L. Sorkin, Patricia L. Walker, Grace J. Wang, Mark C. Xu, Rebecca S. Yang, Barrie Cascella, Wilhelm Cruz, Cynthia K. Holland, Sheri A. McClerkin, Barbara N. Kunkel, Soon Goo Lee, Joseph M. Jez
BIOSCIENCE REPORTS
(2020)
Article
Chemistry, Multidisciplinary
Barbara Cascella, Soon Goo Lee, Sukrit Singh, Joseph M. Jez, Liviu M. Mirica
CHEMICAL COMMUNICATIONS
(2017)