News Item
Physics, Multidisciplinary
Jan Ryckebusch
Summary: A detailed analysis of a nucleon-knockout experiment has proposed a methodological roadmap for addressing ambiguities in data interpretation, offering potential access to nuclear wave functions in unstable nuclei.
Article
Genetics & Heredity
Tamara Jarayseh, Brecht Guillemyn, Hanna De Saffel, Jan Willem Bek, Delfien Syx, Sofie Symoens, Yannick Gansemans, Filip Nieuwerburgh, Sujatha Jagadeesh, Jayarekha Raja, Fransiska Malfait, Paul J. Coucke, Adelbert De Clercq, Andy Willaert
Summary: Bi-allelic mutations in TAPT1 gene lead to a wide range of phenotypes, from severe skeletal and congenital abnormalities to isolated early-onset cataract. A frameshift mutation in the TAPT1 gene was identified in a patient with bilateral early-onset cataract and skeletal abnormalities, expanding the phenotypic spectrum. A zebrafish model with TAPT1 gene knockout exhibited eye malformations, loss of vision, increased photokinetics, and hyperpigmentation, providing insights into the ultrastructural and molecular characteristics of TAPT1 mutations.
Article
Chemistry, Analytical
Deepak Kumar, Navneeta Bansal, Ashish Gupta, Anil Mandhani, Hira Lal, Manoj Kumar, Satya Narain Sankhwar
Summary: This study explores metabolomics-derived biomarkers of prostate cancer in pre- and post-radical prostatectomy patients, identifying glutamate, citrate, and glycine as hallmarks of PC. Changes in these markers were observed during treatment, providing valuable insights into PC progression and potential treatment targets.
JOURNAL OF PHARMACEUTICAL AND BIOMEDICAL ANALYSIS
(2021)
Editorial Material
Multidisciplinary Sciences
Robin Aguilar
Summary: Institutions require experts in racial justice and queer liberation to support and advocate for scientists from marginalized groups, according to Robin Aguilar.
Article
Biochemistry & Molecular Biology
Vincenza D'Angelo, Mauro Giorgi, Emanuela Paldino, Silvia Cardarelli, Francesca R. Fusco, Ilaria Saverioni, Roberto Sorge, Giuseppina Martella, Stefano Biagioni, Nicola B. Mercuri, Antonio Pisani, Giuseppe Sancesario
Summary: The study found regional differences in the expression and aggregation of A2A receptors in the basal ganglia of a DYT1 mouse model of dystonia, with varying levels of expression observed in different subpopulations of neurons. Based on the different expression patterns of A2A receptors among neuronal subpopulations, it suggests that the pathophysiology of dystonia may be associated with a functional imbalance between the indirect and direct pathways.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2021)
Article
Geriatrics & Gerontology
Laurie K. Bale, Sally A. West, Cheryl A. Conover
Summary: The study examined the effects of brain-specific PAPP-A KO in mice on metabolism and lifespan, revealing improvements in lifespan markers in non-specific PAPP-A KO mice with thymic involution. However, brain-specific PAPP-A KO mice showed no significant differences compared to the control group. Thorough characterization of tissue-specific mouse models and consideration of potential germline recombination are crucial for accurate data interpretation.
EXPERIMENTAL GERONTOLOGY
(2021)
Article
Multidisciplinary Sciences
Tsvetana Petrova, Kyle Bennett, Sambit Nanda, Sam Strickson, Cheryl L. Scudamore, Alan R. Prescott, Philip Cohen
Summary: The expression of TRAF6 is crucial for physiological processes. TRAF6[L74H] knock-in mice exhibit a distinct phenotype of autoimmunity and inflammation, which is different from TRAF6 KO mice. The inability to signal via TNF Receptor Superfamily members may explain the different phenotypes observed in TRAF6-deficient mice.
Article
Plant Sciences
Bin Liu, Miguel Santo Domingo, Carlos Mayobre, Ana Montserrat Martin-Hernandez, Marta Pujol, Jordi Garcia-Mas
Summary: Fruit ripening in melon is regulated by the gene CmNAC-NOR, and mutations in this gene can affect various aspects of fruit ripening, such as ripening delay, ethylene production, seed development, and flesh firmness. These findings provide insights for modulating the shelf life of melon varieties.
FRONTIERS IN PLANT SCIENCE
(2022)
Article
Multidisciplinary Sciences
Rudra Kashyap, Marielle Balzano, Benoit Lechat, Kathleen Lambaerts, Antonio Luis Egea-Jimenez, Frederique Lembo, Joanna Fares, Sofie Meeussen, Sebastian Kuegler, Anton Roebroek, Guido David, Pascale Zimmermann
Summary: Syntenin plays a crucial role in exosomal transfers by directing endocytosed cargo to budding endosomal membranes and supporting viral/exosomal exchanges. It, along with heparan sulfate proteoglycans, is identified as a key component for macromolecular cargo internalization into cells.
SCIENTIFIC REPORTS
(2021)
Review
Genetics & Heredity
Laura Daniela Ratner, Gaston Emilio La Motta, Olinda Briski, Daniel Felipe Salamone, Rafael Fernandez-Martin
Summary: Pigs serve as an important resource for meat production and modeling human diseases due to their physiological and anatomical similarities to humans. With the revolutionary technology of CRISPR-Cas9 system, it is now possible to precisely modify the porcine genome for biomedical research. The introduction of the system into early stage zygotes or editing cells is necessary to achieve this goal.
FRONTIERS IN GENETICS
(2021)
Article
Ecology
Kevin P. Johnson, Conrad Matthee, Jorge Dona
Summary: This study explores the diversification patterns of mammalian lice and reveals that the major lineages of placental mammal lice originated from a common ancestor and had an avian ancestral host.
NATURE ECOLOGY & EVOLUTION
(2022)
Article
Immunology
Romain Troubat, Samuel Leman, Katleen Pinchaud, Alexandre Surget, Pascal Barone, Sebastien Roger, Anne-Marie Le Guisquet, Bruno Brizard, Catherine Belzung, Vincent Camus
Summary: After exposure to UCMS, P2X7R KO mice showed significant differences in behavioral and neurogenesis compared to the control group, as well as notable changes in the density of brain immune cells. The recruitment rate of peripheral immune cells was unaffected by P2X7R gene expression or antidepressant treatment.
BRAIN BEHAVIOR AND IMMUNITY
(2021)
Article
Food Science & Technology
Cheng Guo, Wangyang Shen, Weiping Jin, Xiwu Jia, Zhili Ji, Jinling Li, Bin Li
Summary: The composition of green tea cream is complex, with polysaccharides, proteins, epigallocatechin gallate (EGCG), and caffeine identified as the main components involved in its formation. These components participate in the formation process in the form of polysaccharide-protein and EGCG-caffeine colloidal particles, leading to synchronized dynamic changes in their levels. The interaction between EGCG or caffeine and macro-molecule components is not the key factor in tea cream microstructure formation, but the complexation between EGCG and caffeine plays a crucial role in the formation of tea cream. Decreasing the concentrations of EGCG and caffeine could be useful in controlling tea cream formation during tea beverage processing and storage.
Article
Biochemistry & Molecular Biology
Chiara Domenicale, Daniela Mercatelli, Federica Albanese, Salvatore Novello, Fabrizio Vincenzi, Katia Varani, Michele Morari
Summary: The levels of dopamine transporter and α-synuclein were found to change in the striatum of G2019S knock-in mice at 12 months of age, but the pathological relevance of these changes remains to be established.
Article
Automation & Control Systems
Jie Zhong, Yang Liu, Jianquan Lu, Weihua Gui
Summary: This study focuses on steady states in genetic regulatory networks and proposes a pinning control method to achieve global stabilization by reducing the impact of perturbations.
IEEE TRANSACTIONS ON AUTOMATIC CONTROL
(2022)
