期刊
TRENDS IN PARASITOLOGY
卷 30, 期 3, 页码 123-129出版社
ELSEVIER SCI LTD
DOI: 10.1016/j.pt.2014.01.001
关键词
Platyhelminthes; Cestoda; Trematoda; piwi; vasa; argonaute; transposable elements; germline; piRNA pathway
类别
资金
- Institute of Biomedical Sciences of The George Washington University
- National Institutes of Health-National Institute of Allergy and Infectious Diseases (NIH-NIAID) [R01AI072773]
Surveillance by RNA interference is central to controlling the mobilization of transposable elements (TEs). In stem cells, Piwi argonaute (Ago) proteins and associated proteins repress mobilization of TEs to maintain genome integrity. This defense mechanism targeting TEs is termed the Piwi-interacting RNA (piRNA) pathway. In this opinion article, we draw attention to the situation that the genomes of cestodes and trematodes have lost the piwi and vasa genes that are hallmark characters of the germline multipotency program. This absence of Piwi-like Agos and Vasa helicases prompts the question: how does the germline of these flatworms withstand mobilization of TEs? Here, we present an interpretation of mechanisms likely to defend the germline integrity of parasitic flatworms.
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