Article
Statistics & Probability
Marie V. Ozanne, Grant D. Brown, Jacob J. Oleson, Iraci D. Lima, Jose W. Queiroz, Selma M. B. Jeronimo, Christine A. Petersen, Mary E. Wilson
JOURNAL OF APPLIED STATISTICS
(2019)
Article
Infectious Diseases
Jaya Chakravarty, Epco Hasker, Sangeeta Kansal, Om Prakash Singh, Paritosh Malaviya, Abhishek Kumar Singh, Ankita Chourasia, Toolika Singh, Medhavi Sudarshan, Akhil Pratap Singh, Bhawana Singh, Rudra Pratap Singh, Bart Ostyn, Michaela Fakiola, Albert Picado, Joris Menten, Jenefer M. Blackwell, Mary E. Wilson, David Sacks, Marleen Boelaert, Shyam Sundar
PLOS NEGLECTED TROPICAL DISEASES
(2019)
Article
Infectious Diseases
Tiffany Y. Borbon, Breanna M. Scorza, Gwendolyn M. Clay, Fellipe Lima Nobre de Queiroz, Alan J. Sariol, Jayden L. Bowen, Yani Chen, Bayan Zhanbolat, Corey P. Parlet, Diogo G. Valadares, Suzanne L. Cassel, William M. Nauseef, Alexander R. Horswill, Fayyaz S. Sutterwala, Mary E. Wilson
PLOS NEGLECTED TROPICAL DISEASES
(2019)
Article
Biology
Marie V. Ozanne, Grant D. Brown, Angela J. Toepp, Breanna M. Scorza, Jacob J. Oleson, Mary E. Wilson, Christine A. Petersen
Article
Immunology
Rohit Sharma, Paulo S. Silveira-Mattos, Vinicius C. Ferreira, Francys A. Rangel, Laise B. Oliveira, Fabiana S. Celes, Sayonara M. Viana, Mary E. Wilson, Camila I. de Oliveira
FRONTIERS IN CELLULAR AND INFECTION MICROBIOLOGY
(2020)
Article
Multidisciplinary Sciences
Han Boon Ong, Simon Clare, Adam Jonathan Roberts, Mary Elizabeth Wilson, Gavin James Wright
SCIENTIFIC REPORTS
(2020)
Article
Parasitology
Upasna Gaur Dixit, Nilda E. Rodriguez, Rachel Polando, Mary Ann McDowell, Mary E. Wilson
Summary: Leishmania infantum primarily resides in macrophages during infection, entering the cells by inducing massive actin accumulation and forming ruffle-like membrane structures. This unique entry mechanism correlates with subsequent fusion with lysosomal markers, impacting the intracellular survival of the parasite.
EXPERIMENTAL PARASITOLOGY
(2021)
Article
Immunology
Om Prakash Singh, Genevieve Syn, Susanne Nylen, Christian Engwerda, David Sacks, Mary E. Wilson, Rajiv Kumar, Jaya Chakravarty, Shyam Sundar, Jenefer M. Blackwell, Michaela Fakiola
Summary: The study demonstrates the unique immunomodulatory effect of interleukin-10 (IL-10) in visceral leishmaniasis (VL) by impacting the production of interferon-gamma and tumor necrosis factor, highlighting the role of IL-10 as a potent immune regulator in VL.
JOURNAL OF INFECTIOUS DISEASES
(2021)
Article
Immunology
Rahul Vijay, Jenna J. Guthmiller, Alexandria J. Sturtz, Sequoia Crooks, Jordan T. Johnson, Lei Li, Linda Yu-Ling Lan, Rosemary L. Pope, Yani Chen, Kai J. Rogers, Nirmal Dutta, Jason E. Toombs, Mary E. Wilson, Patrick C. Wilson, Wendy Maury, Rolf A. Brekken, Noah S. Butler
Summary: This study uncovers the mechanistic link between hemolysis-induced exposure of phosphatidylserine on damaged RBCs and the formation of plasmablast populations in Plasmodium-infected hosts. Additionally, it shows that virus and Trypanosoma infections triggering hemolytic anemia and inflammation also induce exuberant plasmablast responses. Furthermore, targeting polyclonal B cell activation and phosphatidylserine exposure may enhance immune responses against Plasmodium parasites and other infectious diseases associated with anemia.
JOURNAL OF EXPERIMENTAL MEDICINE
(2021)
Correction
Multidisciplinary Sciences
Han Boon Ong, Simon Clare, Adam Jonathan Roberts, Mary Edythe Wilson, Gavin James Wright
Summary: The paper has been amended and the revised version can be accessed through a link at the top of the paper.
SCIENTIFIC REPORTS
(2021)
Correction
Microbiology
Ellen T. Kiser, Mark A. Wacker, Upasna Gaur Dixit, Hemali Batra-Sharma, Yani Chen, Mary E. Wilson
Article
Microbiology
Ellen T. Kiser, Mark A. Wacker, Upasna Gaur Dixit, Hemali Batra-Sharma, Yani Chen, Mary E. Wilson
Summary: Visceral leishmaniasis is a potentially fatal disease caused by Leishmania protozoa. Increased fat and cholesterol intake prior to the infection lead to hepatic inflammatory environment and reduced parasite burden in the liver. The relationship between diet and inflammatory responses may provide opportunities to modify the therapeutic approach to microbial infections.
Article
Infectious Diseases
Juliana Silva, Ana Isabelle Pinheiro, Maria Luiza Dourado, Lilian Medina, Adriano L. Queiroz, Luiz Henrique Guimaraes, Marcus Miranda E. Lessa, Ednaldo M. Lago, Paulo Roberto L. Machado, Mary Wilson, Edgar Carvalho, Albert Schriefer
Summary: This study investigates the genetic characteristics of a population of L. braziliensis causing human leishmaniasis. The findings suggest that L. braziliensis can maintain stable populations and exhibit robust genetic recombination in foci of human leishmaniasis.
PLOS NEGLECTED TROPICAL DISEASES
(2022)
Article
Infectious Diseases
Helin G. Hernandez, Grant D. Brown, Iraci D. Lima, Jose F. Coutinho, Mary E. Wilson, Eliana L. T. Nascimento, Selma M. B. Jeronimo, Christine A. Petersen, Jacob J. Oleson
Summary: This study aimed to estimate regions of high visceral leishmaniasis (VL) risk in Rio Grande do Norte, Brazil from 2007 to 2020. Lower socioeconomic status was found to be associated with higher VL risk. Additionally, there is a high probability of increasing VL risk in the municipalities of Natal, Patu, and Pau dos Ferros, highlighting the need for specific public health interventions.
PLOS NEGLECTED TROPICAL DISEASES
(2023)
Article
Multidisciplinary Sciences
Diogo Garcia Valadares, Owen Scott Clay, Yani Chen, Breanna Mary Scorza, Suzanne Louise Cassel, Fayyaz Shiraz Sutterwala, Mary Edythe Wilson
Summary: The NLR protein NLRP12 is important for innate immunity, but its mechanism is still not fully understood. In this study, mice lacking Nlrp12 showed higher levels of parasite replication in the liver after infection with Leishmania infantum compared to wild-type mice, and the parasites failed to disseminate to the spleen. Most of the parasites in the liver were found in dendritic cells (DCs), while the number of infected DCs in the spleen was reduced. Furthermore, Nlrp12(-/-) DCs showed lower expression of CCR7, failed to migrate towards CCL19 or CCL21 in chemotaxis assays, and migrated poorly to draining lymph nodes after sterile inflammation. Leishmania-infected Nlpr12(-/-) DCs were also less effective at transporting parasites to lymph nodes compared to wild-type DCs. These findings suggest that Nlrp12-expressing DCs are necessary for efficient dissemination and immune clearance of L. infantum from the site of initial infection, partly due to defective CCR7 expression.
