期刊
TRENDS IN PARASITOLOGY
卷 28, 期 11, 页码 486-495出版社
ELSEVIER SCI LTD
DOI: 10.1016/j.pt.2012.08.006
关键词
malaria; Plasmodium; epigenome; chromatin; nucleosome; histone modification; histone variant
类别
资金
- Netherlands Organization for Scientific Research [93511023, 021.001.011]
- European Commission [EU-FP7_242095]
- United States Government National Institute of Allergy and Infectious Diseases
It is becoming increasingly evident that epigenetic mechanisms that act on and regulate chromatin structure play a key role in the development, adaptation, and survival of the malaria parasite within its human host. The study of epigenetics in Plasmodium falciparum started to flourish in recent years due to improvement of genomic technologies. Here we summarize the knowledge gained from genome-wide localization profiling of different epigenetic features, and discuss hypotheses emerging from the analysis of these 'descriptive' epigenetic maps. Furthermore, we highlight key questions to be answered, and provide a glimpse of developments required to gain true mechanistic understanding and to lift this maturing field to the next level.
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