期刊
TRENDS IN PARASITOLOGY
卷 28, 期 6, 页码 248-257出版社
ELSEVIER SCI LTD
DOI: 10.1016/j.pt.2012.03.006
关键词
systems immunology; malaria; Plasmodium falciparum
类别
资金
- Intramural NIH HHS [Z99 AI999999, ZIA AI001155-01] Funding Source: Medline
Plasmodium falciparum malaria remains a global public health threat. Optimism that a highly effective malaria vaccine can be developed stems in part from the observation that humans can acquire immunity to malaria through experimental and natural P. falciparum infection. Recent advances in systems immunology could accelerate efforts to unravel the mechanisms of acquired immunity to malaria. Here, we review the tools of systems immunology, their current limitations in the context of human malaria research, and the human 'models' of malaria immunity to which these tools can be applied.
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