期刊
TRENDS IN PARASITOLOGY
卷 28, 期 7, 页码 289-296出版社
ELSEVIER SCI LTD
DOI: 10.1016/j.pt.2012.04.003
关键词
levamisole; nematode; acetylcholine; ion channel receptor; subtypes; oocyte expression; anthelmintic; resistance
类别
资金
- Institut National de la Recherche Agronomique (INRA)
- Embassy of France in the US
- National Institute of Allergy and Infectious Diseases [R56 AI047194-11, R21AI092185-01]
Levamisole and pyrantel are old (1965) but useful anthelmintics that selectively activate nematode acetylcholine ion channel receptors; they are used to treat roundworm infections in humans and animals. Interest in their actions has surged, giving rise to new knowledge and technical advances, including an ability to reconstitute receptors that reveal more details of modes of action/resistance. We now know that the receptors are plastic and may form diverse species-dependent subtypes of receptor with different sensitivities to individual cholinergic anthelmintics. Understanding the biology of the levamisole receptors is expected to inform other studies on anthelmintics (ivermectin and emodepside) that act on ion channels.
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