Review
Biochemistry & Molecular Biology
Marcelle Mehu, Chandrakala Aluganti Narasimhulu, Dinender K. Singla
Summary: Atherosclerosis is a chronic disease characterized by damage to the intima, inflammatory cell recruitment, and lipid accumulation followed by calcification and plaque rupture. Inflammation is believed to play a crucial role in the development and progression of the disease. This paper discusses the various types of inflammatory cells involved in atherosclerosis and their significance in the disease's development and progression. Understanding the role of these cells at different stages of the disease provides valuable insights for targeted therapy.
Article
Biochemistry & Molecular Biology
Javiera Villar, Lea Ouaknin, Adeline Cros, Elodie Segura
Summary: During inflammation, monocytes can differentiate into either macrophages or dendritic cells. This study used single-cell RNA sequencing and computational analysis to identify different pathways of differentiation for these two cell types. It also identified key transcription factors involved in monocyte fate commitment.
Article
Cardiac & Cardiovascular Systems
Guoshuai Feng, Geetika Bajpai, Pan Ma, Andrew Koenig, Andrea Bredemeyer, Inessa Lokshina, Lulu Lai, Irmgard Foerster, Florian Leuschner, Daniel Kreisel, Kory J. Lavine
Summary: This study identified CCL17 as a proinflammatory mediator in CCR2(+) macrophages and dendritic cells, and suggested that inhibiting CCL17 could promote Treg recruitment and suppress myocardial inflammation.
Review
Immunology
Stefan Schuelke, Stefanie Gilles, Adan C. Jirmo, Johannes U. Mayer
Summary: Antigen-presenting cells (APCs) play a critical role in bridging innate and adaptive immune responses by presenting antigens to T cells. In allergies, APCs drive immune responses against harmless antigens. Different types of APCs contribute differently to tissue-specific immune tolerance, allergen sensitization, and allergic inflammation.
EUROPEAN JOURNAL OF IMMUNOLOGY
(2023)
Article
Immunology
Kyle T. Cunningham, Conor M. Finlay, Kingston H. G. Mills
Summary: These findings demonstrate that helminth products can modulate HSCs to promote development of anti-inflammatory myeloid cells that attenuate T cell-mediated autoimmune disease.
JOURNAL OF IMMUNOLOGY
(2021)
Review
Immunology
Elise G. Liu, Xiangyun Yin, Anush Swaminathan, Stephanie C. Eisenbarth
Summary: Food allergy mediated by food-specific immunoglobulin E (IgE) antibodies can cause a variety of symptoms, including life-threatening anaphylaxis. Different types of dendritic cells (DCs) together with other immune cells regulate T cell and B cell antibody responses, determining oral tolerance versus allergy.
FRONTIERS IN IMMUNOLOGY
(2021)
Article
Biochemistry & Molecular Biology
Faezzah Baharom, Ramiro A. Ramirez-Valdez, Ahad Khalilnezhad, Shabnam Khalilnezhad, Marlon Dillon, Dalton Hermans, Sloane Fussell, Kennedy K. S. Tobin, Charles-Antoine Dutertre, Geoffrey M. Lynn, Soren Muller, Florent Ginhoux, Andrew S. Ishizuka, Robert A. Seder
Summary: Therapeutic cancer vaccines aim to enhance tumor-specific T cell immunity, but suppressive mechanisms within the tumor microenvironment can limit T cell function. This study investigated how different routes of vaccination impact intratumoral myeloid cells and found that intravenous administration of a nanoparticle vaccine induced tumor regression mediated by systemic type I interferon, leading to a reduction in intratumoral monocytes expressing immune-regulatory genes. In humans, these gene signatures are associated with worse outcomes. These results suggest that combining the generation of tumor-specific CD8+ T cells with remodeling of the tumor microenvironment holds promise for tumor immunotherapy.
Article
Multidisciplinary Sciences
Anthos Christofides, Carol Cao, Rinku Pal, Halil Aksoylar, Vassiliki A. Boussiotis
Summary: The respiratory tract requires a precisely regulated immune system to protect the body while also mediating immune responses in pathological conditions. Immune cells in the lung have unique immunophenotypic properties, which can be identified using flow cytometry to study changes in disease models.
JOVE-JOURNAL OF VISUALIZED EXPERIMENTS
(2021)
Article
Medicine, Research & Experimental
Megha Srinivas, Preeti Sharma, Siddharth Jhunjhunwala
Summary: Research findings suggest that immune cells can phagocytose particles under constant fluidic flow. Different cell types show similar or better uptake rates under flow conditions. Even in the presence of crowded red blood cells, neutrophils and monocytes are able to uptake particles while flowing.
MOLECULAR PHARMACEUTICS
(2021)
Review
Immunology
Matheus B. Carneiro, Nathan C. Peters
Summary: This review focuses on the interaction between Leishmania amazonensis infection and host innate immune response, particularly addressing the impact of adaptive immunity on phagocytic host cell recruitment and activation. Experimental observations indicate that most mouse strains are susceptible to L. amazonensis infection, unlike other Leishmania species. The CD4(+) T helper (Th)1/Th2 paradigm does not fully explain the chronic disease established by L. amazonensis, with recent findings complicating the understanding of the Th1/Th2 paradigm.
FRONTIERS IN IMMUNOLOGY
(2021)
Article
Cell Biology
Joseph Hiatt, Devin A. Cavero, Michael J. McGregor, Weihao Zheng, Jonathan M. Budzik, Theodore L. Roth, Kelsey M. Haas, David Wu, Ujjwal Rathore, Anke Meyer-Franke, Mohamed S. Bouzidi, Eric Shifrut, Youjin Lee, Vigneshwari Easwar Kumar, Eric Dang, David E. Gordon, Jason A. Wojcechowskyj, Judd F. Hultquist, Krystal A. Fontaine, Satish K. Pillai, Jeffery S. Cox, Joel D. Ernst, Nevan J. Krogan, Alexander Marson
Summary: A method for delivering CRISPR-Cas9 ribonucleoprotein complexes via nucleofection into human monocytes has been developed for precise gene knockout and differentiation into macrophages or dendritic cells. This system shows promise for genetic studies of human myeloid cells in various areas such as immune signaling, inflammation, cancer immunology, host-pathogen interactions, and beyond.
Article
Immunology
Gueliz Tuba Barut, Marco Kreuzer, Remy Bruggmann, Artur Summerfield, Stephanie C. Talker
Summary: Dendritic and monocytic cells work together to initiate and shape adaptive immune responses in secondary lymphoid tissue. By sequencing mononuclear phagocytes at the single-cell level in mesenteric lymph nodes of cows, researchers identified distinct clusters of dendritic cells and monocytes/macrophages with different transcriptomic profiles. They also discovered subsets of highly activated migratory dendritic cells and potential differentiation paths for certain cell types. Additionally, they found sub-clusters of monocytes and macrophages driven by pro- or anti-inflammatory gene expression signatures. This study provides valuable insight into the functional properties and differentiation trajectories of mononuclear phagocytes in the immune system.
FRONTIERS IN IMMUNOLOGY
(2023)
Review
Immunology
Kok Fei Chan, Jessica Da Gama Duarte, Simone Ostrouska, Andreas Behren
Summary: γδ T cells play a crucial role in clearing tumors and pathogen-infected cells through their distinct recognition and immune response properties. They interact with other immune cells upon activation, influencing the outcome of immune responses.
FRONTIERS IN IMMUNOLOGY
(2022)
Article
Cell Biology
Shuo Huang, George S. Deepe
Summary: This study highlights the critical role of Notch signaling in host defense against pulmonary histoplasmosis. Inhibition of Notch downstream signaling impaired fungal clearance and affected the differentiation of monocyte-derived DCs and polarization of macrophages to M2.
JOURNAL OF LEUKOCYTE BIOLOGY
(2022)
Review
Immunology
Stephen J. Jenkins, Judith E. Allen
Summary: Macrophages share common functions but also exhibit tissue-specific functionality. They may persist through tissue perturbations and inflammatory events, impacting cell function.
EUROPEAN JOURNAL OF IMMUNOLOGY
(2021)
Article
Infectious Diseases
Holly Seale, Anita E. Heywood, Julie Leask, Meru Sheel, David N. Durrheim, Katarzyna Bolsewicz, Rajneesh Kaur
Summary: The study found that the majority of respondents held positive views towards vaccination, particularly among females, older individuals, those with chronic diseases, and those with private health insurance. Furthermore, most respondents indicated that the support of family and friends is important for their decision to vaccinate.
BMC INFECTIOUS DISEASES
(2021)
Article
Parasitology
Shannon M. Hedtke, Patsy A. Zendejas-Heredia, Patricia M. Graves, Sarah Sheridan, Meru Sheel, Saipale D. Fuimaono, Colleen L. Lau, Warwick N. Grant
Summary: This study explored the genetic variation of Wuchereria bancrofti worms in Polynesia, particularly in American Samoa. The research found that the resurgent parasites in American Samoa represent a single population and did not observe significant population genetic structure among regions or villages in 2016. The study provides valuable insights for informing strategies on managing the resurgence and elimination of lymphatic filariasis.
INTERNATIONAL JOURNAL FOR PARASITOLOGY
(2021)
Letter
Public, Environmental & Occupational Health
Amy Vassallo, Kate Womersley, Robyn Norton, Meru Sheel
LANCET GLOBAL HEALTH
(2021)
Article
Biochemistry & Molecular Biology
Richard J. Mills, Sean J. Humphrey, Patrick R. J. Fortuna, Mary Lor, Simon R. Foster, Gregory A. Quaife-Ryan, Rebecca L. Johnston, Troy Dumenil, Cameron Bishop, Rajeev Rudraraju, Daniel J. Rawle, Thuy Le, Wei Zhao, Leo Lee, Charley Mackenzie-Kludas, Neda R. Mehdiabadi, Christopher Halliday, Dean Gilham, Li Fu, Stephen J. Nicholls, Jan Johansson, Michael Sweeney, Norman C. W. Wong, Ewelina Kulikowski, Kamil A. Sokolowski, Brian W. C. Tse, Lynn Devilee, Holly K. Voges, Liam T. Reynolds, Sophie Krumeich, Ellen Mathieson, Dad Abu-Bonsrah, Kathy Karavendzas, Brendan Griffen, Drew Titmarsh, David A. Elliott, James McMahon, Andreas Suhrbier, Kanta Subbarao, Enzo R. Porrello, Mark J. Smyth, Christian R. Engwerda, Kelli P. A. MacDonald, Tobias Bald, David E. James, James E. Hudson
Summary: Cardiac injury and dysfunction in COVID-19 patients increase mortality risk. An inflammatory cytokine-storm can induce diastolic dysfunction, but BET inhibitors show promise in preventing cardiac damage and dysfunction induced by the virus.
Article
Infectious Diseases
Paul R. Chapman, Rebecca Webster, Paul Giacomin, Stacey Llewellyn, Luke Becker, Mark S. Pearson, Fabian De Labastida Rivera, Peter O'Rourke, Christian R. Engwerda, Alex Loukas, James S. McCarthy
Summary: The study aimed to develop a live attenuated human hookworm vaccine, consisting of a dose-finding study and a challenge study. Results showed that vaccination with UVC-attenuated N americanus larvae induced humoral and cellular responses to hookworm antigens and reduced larval output after challenge with unattenuated larvae. More research is needed to confirm protective efficacy.
LANCET INFECTIOUS DISEASES
(2021)
Article
Infectious Diseases
Pippa McDermid, Adam Craig, Meru Sheel, Holly Seale
Summary: This study analyzes the support provided by 11 countries to their citizens stranded abroad during the COVID-19 pandemic. The results show significant variations in the availability of information and services across countries, highlighting gaps, inconsistencies, and potential inequities in the support provided. The study also raises issues related to the quality, accessibility, and usability of information.
BMC INFECTIOUS DISEASES
(2022)
Review
Infectious Diseases
Busayo I. Ajuwon, Isabelle Yujuico, Katrina Roper, Alice Richardson, Meru Sheel, Brett A. Lidbury
Summary: The study revealed a prevalence of 9.5% for Hepatitis B virus (HBV) in Nigeria, with a prevalence above 8% classified as high. The highest prevalence was found in rural areas, with the North West region having the highest prevalence among Nigeria's six geopolitical zones. Variations in prevalence were attributed to differences in settings and geographical regions.
BMC INFECTIOUS DISEASES
(2021)
Article
Infectious Diseases
Angela M. Cadavid Restrepo, Katherine Gass, Kimberly Y. Won, Meru Sheel, Keri Robinson, Patricia M. Graves, Saipale Fuimaono, Colleen L. Lau
Summary: This study aims to determine if antibodies (Abs) may have provided a timelier indication of LF resurgence in American Samoa. The study found that schools with higher prevalence of specific antibodies were more likely to be antigen-positive in subsequent surveys. Therefore, antibodies could potentially provide earlier signals of resurgence and enable a timelier response.
INTERNATIONAL JOURNAL OF INFECTIOUS DISEASES
(2022)
Review
Cell Biology
Siddharth S. Singh, Shashi B. Chauhan, Awnish Kumar, Shashi Kumar, Christian R. Engwerda, Shyam Sundar, Rajiv Kumar
Summary: AREG, as a ligand for EGFR, plays a crucial role in tissue repair, inflammation, and immunity. It triggers signaling events essential for cellular processes and is expressed by immune cells under different inflammatory and pathogenic conditions.
JOURNAL OF CELLULAR PHYSIOLOGY
(2022)
Article
Health Care Sciences & Services
Marta Lomazzi, Meru Sheel, Asha Singh
JOURNAL OF PUBLIC HEALTH POLICY
(2022)
Article
Immunology
Meru Sheel, Nicholas Wood, Kristine Macartney, Jim Buttery, Nicole Dinsmore, Helen Marshall, Elizabeth Elliott, Anne Kynaston, Peter Richmond, Dan Chateau, Peter McIntyre
Summary: Studies have found that cases of intussusception within 21 days of receiving rotavirus vaccine are more severe and occur at a younger age. However, after adjusting for age and sex, the severity of intussusception is not related to the vaccine.
PEDIATRIC INFECTIOUS DISEASE JOURNAL
(2022)
Article
Medicine, General & Internal
Pippa McDermid, Adam Craig, Meru Sheel, Katrina Blazek, Siobhan Talty, Holly Seale
Summary: This study aimed to evaluate the psychological and financial distress faced by citizens and permanent residents stranded abroad due to COVID-19 travel restrictions. The survey revealed that individuals stranded abroad are experiencing significant psychological stress and financial difficulties, with a majority hoping to return to the Oceania region. Factors such as financial stress, employment changes, age, perceived risk of contracting COVID-19 abroad, and duration of strandedness were found to be significantly associated with moderate-to-extremely severe levels of depression, anxiety, and stress.
Article
Infectious Diseases
Kinley Wangdi, Meru Sheel, Saipale Fuimaono, Patricia M. Graves, Colleen L. Lau
Summary: This study investigated clustering and hotspots of lymphatic filariasis using different non-spatial and spatial methods. The results showed higher intra-cluster correlation coefficients at the household level compared to the village level for all infection markers. Semivariograms identified significant spatial dependence for all markers. Significant spatial clustering was observed in certain locations using Kuldorff's scan statistic, while Getis-Ord Gi* statistic identified hotspots in different areas.
PLOS NEGLECTED TROPICAL DISEASES
(2022)
Article
Microbiology
M. Farouk Chughlay, Karen Barnes, Myriam El Gaaloul, Nada Abla, Jorg J. Mohrle, Paul Griffin, Paul van Giersbergen, Stephanie E. Reuter, Hayley B. Schultz, Anita Kress, Peter Tapley, Rebecca A. Webster, Timothy Wells, James S. McCarthy, Bridget E. Barber, Louise Marquart, Michelle J. Boyle, Christian R. Engwerda, Stephan Chalon
Summary: This study investigated the safety and pharmacodynamic profile of the combination of antimalarial artemether-lumefantrine and the JAK1/2 inhibitor ruxolitinib. The results showed that the combination therapy was well-tolerated and effectively inhibited the dysfunctional immune response.
ANTIMICROBIAL AGENTS AND CHEMOTHERAPY
(2022)
Article
Infectious Diseases
Meru Sheel, Colleen L. Lau, Sarah Sheridan, Saipale Fuimaono, Patricia M. Graves
Summary: The prevalence of circulating filarial antigen using rapid point-of-care tests is an important indicator for monitoring and surveillance of lymphatic filariasis. In 2015, the ICT was replaced with the FTS, which showed higher reported sensitivity. Despite differences in sensitivity, no changes in recommended surveillance targets were made.
TROPICAL MEDICINE AND INFECTIOUS DISEASE
(2021)
