期刊
TRENDS IN PARASITOLOGY
卷 28, 期 9, 页码 377-384出版社
ELSEVIER SCI LTD
DOI: 10.1016/j.pt.2012.07.001
关键词
protozoan; exhaustion; parasite; Toxoplasma; Leishmania; Plasmodium; T cell
类别
资金
- National Institutes of Health (NIH) [AI 33325]
Protozoan parasites cause severe morbidity and mortality in humans worldwide, especially in developing countries where access to chemotherapeutic agents is limited. Although parasites initially evoke a robust immune response, subsequent immunity fails to clear infection, ultimately leading to the chronic stage. This enigmatic situation was initially addressed in chronic viral models, where T cells lose their function, a phenomenon referred to as 'exhaustion'. However, recent studies demonstrate that this paradigm can be extended to protozoan diseases as well, although with notable differences. These studies have revealed that T cell responses generated against Toxoplasma gondii, Plasmodium sp., and Leishmania sp. can become dysfunctional. This review discusses T cell exhaustion in parasitic infection, mechanisms of development, and a possible role in disease outcome.
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