Review
Neurosciences
R. J. Pasterkamp, K. Burk
Summary: The translation explains how axons navigate through the nervous system and the role of endosomes in intracellular signaling. It highlights the importance of endosome trafficking for axon guidance receptors and their localization for proper function and signaling pathways.
PROGRESS IN NEUROBIOLOGY
(2021)
Article
Multidisciplinary Sciences
Oguzhan Baltaci, Mikael Egebjerg Pedersen, Tessa Sherry, Ava Handley, Goda Snieckute, Wei Cao, Matilda Haas, Stuart Archer, Roger Pocock
Summary: Coordinated expression of cell adhesion and signaling molecules is crucial for brain development. This study found that SMA-6 acts independently of DAF-4 to control neuronal guidance by limiting the expression of NLR-1.
Article
Biochemistry & Molecular Biology
Chinh Thanh Nguyen, Van Minh Nguyen, Sangyun Jeong
Summary: The role of Off-track receptor tyrosine kinase (OTK) in motor axon pathfinding in Drosophila is not well understood. This study found that OTK mediates forward and reverse signaling in intersegmental nerve b (ISNb) motor axon pathfinding and interacts with the Sema-1a/PlexA and Wnt signaling pathways.
INSECT BIOCHEMISTRY AND MOLECULAR BIOLOGY
(2022)
Article
Biochemistry & Molecular Biology
Ross A. Robinson, Samuel C. Griffiths, Lieke L. van de Haar, Tomas Malinauskas, Eljo Y. van Battum, Pavol Zelina, Rebekka A. Schwab, Dimple Karia, Lina Malinauskaite, Sara Brignani, Marleen H. van den Munkhof, Ozge Dudukcu, Anna A. De Ruiter, Dianne M. A. Van den Heuvel, Benjamin Bishop, Jonathan Elegheert, A. Radu Aricescu, R. Jeroen Pasterkamp, Christian Siebold
Summary: The study reveals that Neogenin (NEO1) can be simultaneously affected by both Netrin-1 (NET1) and repulsive guidance molecule (RGM) ligands, forming a ternary NEO1-NET1-RGM complex that triggers reciprocal silencing of downstream signaling. This complex, existing in the cell membrane as a trimer-of-trimers super-assembly, inhibits cell growth and migration by preventing the formation of signaling-compatible complexes and clustering of NEO1 ectodomains.
Article
Neurosciences
Haruyuki Kamiya
Summary: This article investigates the passive subthreshold voltage signaling in axons and its impact on transmitter release. The simulation results show that subthreshold voltage signals can reduce calcium currents by decreasing the amplitude of action potentials and modulate synaptic function by enhancing transmitter release.
FRONTIERS IN CELLULAR NEUROSCIENCE
(2022)
Article
Developmental Biology
Nikole R. Zuniga, Alexandre Dumoulin, Giuseppe Vaccaro, Esther T. Stoeckli
Summary: During neural circuit formation, the switch in receptor expression is crucial for axons to navigate from one intermediate target to the next. We identified Cables1 as a key linker that regulates receptor phosphorylation and controls axon navigation in the developing spinal cord.
Article
Neurosciences
Anna M. Lipkin, Margaret M. Cunniff, Perry W. E. Spratt, Stefan M. Lemke, Kevin J. Bender
Summary: The study revealed that in mouse layer 5 prefrontal pyramidal neurons, calcium channels were distributed differently, with Ca(V)3 channels leading to high-spot calcium influx in specific regions, while Ca(V)2 channels localized to non-hotspot areas.
JOURNAL OF NEUROSCIENCE
(2021)
Article
Biochemistry & Molecular Biology
Silvia Vicenzi, Lisa Foa, Robert J. Gasperini
Summary: The neurotransmitter serotonin can act as both an attractive and repulsive guidance cue for rodent sensory neurons in vitro, with extracellular gradients of 50 mu M serotonin inducing attraction mediated by the serotonin 5-HT2a receptor and 100 mu M serotonin inducing repulsion mediated by the 5-HT1b receptor. High resolution imaging of growth cones showed that these receptors signal through their canonical pathways to shape neuronal circuit formation during development.
CELLULAR AND MOLECULAR LIFE SCIENCES
(2021)
Review
Biochemistry & Molecular Biology
Rosa Manzoli, Lorenzo Badenetti, Michela Rubin, Enrico Moro
Summary: This review discusses the crucial role of lysosomes in the regulation of axonal guidance cue delivery, localization, and function, providing evidence to understand the relationship between lysosomal storage disorders and neurodegenerative diseases.
Review
Biochemistry & Molecular Biology
Weiyun Zhang, Peiyi Luo, Xiaohan Liu, Ruoxi Cheng, Shuxian Zhang, Xiao Qian, Fang Liu
Summary: Fibroblast growth factors (FGFs) have been extensively studied for their role in regulating essential cellular activities and have recently been found to play a crucial role in the formation of intricate connections within the nervous system. FGF and FGFR signaling pathways are important in axon guidance, where they act as chemoattractants or chemorepellents. This review provides an overview of the functions of FGFs in axonal navigation and discusses the mechanisms involved, including intracellular signaling integration and cytoskeleton dynamics.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2023)
Review
Cell Biology
Melody Atkins, Xavier Nicol, Coralie Fassier
Summary: The establishment of neuronal connectivity relies on the microtubule cytoskeleton, which plays multiple roles in providing support, transport, and signaling for neuronal growth. The precise regulation of microtubule functions is crucial for neuronal wiring and connectivity refinement, and defects in this regulation can lead to neurodevelopmental disorders. This review summarizes recent studies on how microtubule composition, post-translational modifications, and associated proteins influence axon guidance and pruning to build functional neuronal circuits. It also highlights the importance of the tubulin code and molecular links between microtubule regulation and guidance signals in wiring the nervous system.
SEMINARS IN CELL & DEVELOPMENTAL BIOLOGY
(2023)
Review
Biochemistry & Molecular Biology
Miguel E. Dominguez-Romero, Paula G. Slater
Summary: The growth cone is a critical structure during neuronal development and regeneration, detecting and integrating signals to reach its final destination. After neuronal injuries in mammals, only axons in the peripheral nervous system are able to regenerate, while the ones from the central nervous system fail to do so.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2021)
Review
Cell Biology
Eloisa Herrera, Augusto Escalante
Summary: The development of the nervous system involves neurogenesis, neuronal specification, axonal navigation, and circuits assembly. The growth cone located at the tip of the axon plays a crucial role in guiding axons towards their final targets. The transcriptional control and epigenetic regulation of axon guidance molecules are important for determining specific axonal behaviors.
FRONTIERS IN CELL AND DEVELOPMENTAL BIOLOGY
(2022)
Article
Multidisciplinary Sciences
Gen Honda, Nen Saito, Taihei Fujimori, Hidenori Hashimura, Mitsuru J. Nakamura, Akihiko Nakajima, Satoshi Sawai
Summary: Through quantitative image analysis of Dictyostelium on microfabricated surfaces, it was found that the macropinocytic membrane cup is a distinct mode of topographical guidance driven by the Ras/PI3K/F-actin signaling patch, showing unique responses to micrometer-scale topographical features. This topographical guidance differs from previously known guidance mechanisms that depend on nanometer-scale curvature sensing proteins or stress fibers.
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA
(2021)
Article
Neurosciences
Bekir Altas, Andrea J. Romanowski, Garrett W. Bunce, Alexandros Poulopoulos
Summary: The subcellular localization of mTOR in neurons has significant implications for nervous system development, function, and disease. The model of mTOR outposts suggests that localized signaling is selected and amplified through these structures.
FRONTIERS IN CELLULAR NEUROSCIENCE
(2022)
Article
Biochemical Research Methods
Merja Joensuu, Ramon Martinez-Marmol, Pranesh Padmanabhan, Nick R. Glass, Nela Durisic, Matthew Pelekanos, Mahdie Mollazade, Giuseppe Balistreri, Rumelo Amor, Justin J. Cooper-White, Geoffrey J. Goodhill, Frederic A. Meunier
Article
Neurosciences
Fatima Abbas, Marcus A. Triplett, Geoffrey J. Goodhill, Martin P. Meyer
FRONTIERS IN NEURAL CIRCUITS
(2017)
Article
Biology
Pranesh Padmanabhan, Geoffrey J. Goodhill
PROCEEDINGS OF THE ROYAL SOCIETY B-BIOLOGICAL SCIENCES
(2018)
Review
Neurosciences
Lilach Avitan, Geoffrey J. Goodhill
TRENDS IN NEUROSCIENCES
(2018)
Review
Neurosciences
Emiliano Marachlian, Lilach Avitan, Geoffrey J. Goodhill, German Sumbre
FRONTIERS IN NEURAL CIRCUITS
(2018)
Correction
Multidisciplinary Sciences
Adekunle T. Bademosi, Elsa Lauwers, Pranesh Padmanabhan, Lorenzo Odierna, Ye Jin Chai, Andreas Papadopulos, Geoffrey J. Goodhill, Patrik Verstreken, Bruno van Swinderen, Frederic A. Meunier
NATURE COMMUNICATIONS
(2018)
Article
Biochemical Research Methods
Brendan A. Bicknell, Zac Pujic, Peter Dayan, Geoffrey J. Goodhill
PLOS COMPUTATIONAL BIOLOGY
(2018)
Retraction
Biology
Huyen Nguyen, Peter Dayan, Zac Pujic, Justin Cooper-White, Geoffrey J. Goodhill
Article
Biochemical Research Methods
Marcus A. Triplett, Lilach Avitan, Geoffrey J. Goodhill
PLOS COMPUTATIONAL BIOLOGY
(2018)
Article
Multidisciplinary Sciences
Brendan A. Bicknell, Zac Pujic, Julia Feldner, Irina Vetter, Geoffrey J. Goodhill
Article
Physics, Multidisciplinary
Jan Molter, Geoffrey J. Goodhill
Article
Biochemical Research Methods
Marcus A. Triplett, Zac Pujic, Biao Sun, Lilach Avitan, Geoffrey J. Goodhill
PLOS COMPUTATIONAL BIOLOGY
(2020)
Article
Biology
Lilach Avitan, Zac Pujic, Jan Molter, Shuyu Zhu, Biao Sun, Geoffrey J. Goodhill
Summary: The study found that spontaneous and evoked neural activity in the larval zebrafish tectum changes over development, but they do not converge. This result does not support the hypothesis that spontaneous activity evolves to form a Bayesian prior for evoked activity.
Article
Computer Science, Artificial Intelligence
Marcus A. Triplett, Geoffrey J. Goodhill
Summary: Understanding brain function requires disentangling high-dimensional neural activity, and calcium imaging is a popular monitoring technique, but lacking computational tools. This study develops a flexible modeling framework for identifying low-dimensional latent factors in calcium imaging data, revealing the significant impact of multiplicative excitability fluctuations on trial-to-trial variations in evoked responses.
NEURAL COMPUTATION
(2022)
Article
Neurosciences
Shuyu I. Zhu, Michael H. McCullough, Zac Pujic, Jordan Sibberas, Biao Sun, Thomas Darveniza, Bianca Bucknall, Lilach Avitan, Geoffrey J. Goodhill
Summary: Autism spectrum disorders (ASDs) have a developmental origin and their impact on early development of behavior and sensory coding is not well understood. Fragile X syndrome (FXS) is the most common inherited form of autism caused by a mutation in FMR1. Zebrafish with fmr1 mutation display anxiety-like behavior, hyperactivity, and sensory hypersensitivity. The study shows that zebrafish with fmr1 mutation also exhibit changes in hunting behavior, sensory coding, and social interaction.
JOURNAL OF NEUROSCIENCE
(2023)
