期刊
TRENDS IN NEUROSCIENCES
卷 37, 期 11, 页码 653-662出版社
ELSEVIER SCIENCE LONDON
DOI: 10.1016/j.tins.2014.07.001
关键词
CaMKII; psychiatric disease; depression; addiction; schizophrenia; epilepsy
资金
- Whitehall Foundation
- Michigan State University College of Natural Sciences
Although it has been known for decades that hippocampal calcium/calmodulin (CaM)-dependent protein kinase II (CaMKII) plays an essential role in learning and memory consolidation, the roles of CaMKII in other brain regions are only recently being explored in depth. A series of recent studies suggest that CaMKII dysfunction throughout the brain may underlie myriad neuropsychiatric disorders, including drug addiction, schizophrenia, depression, epilepsy, and multiple neurodevelopmental disorders, perhaps through maladaptations in glutamate signaling and neuroplasticity. I review here the structure, function, subcellular localization, and expression patterns of CaMKII isoforms, as well as recent advances demonstrating that disturbances in these properties may contribute to psychiatric disorders.
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