Article
Cardiac & Cardiovascular Systems
Xuefei Liu, Hong Zheng
Summary: The study revealed that both Sirt1 and FoxO1 are key modulators of leptin signaling in the hypothalamus, contributing to the over activation of sympathetic nerves and inflammation in obesity.
JOURNAL OF THE AMERICAN HEART ASSOCIATION
(2021)
Article
Clinical Neurology
Huy Pho, Slava Berger, Carla Freire, Lenise J. Kim, Mi-Kyung Shin, Stone R. Streeter, Nishitha Hosamane, Meaghan E. Cabassa, Frederick Anokye-Danso, Olga Dergacheva, Mateus R. Amorim, Thomaz Fleury-Curado, Jonathan C. Jun, Alan R. Schwartz, Rexford S. Ahima, David Mendelowitz, Vsevolod Y. Polotsky
Summary: This study demonstrates that restoring leptin signaling in the dorsomedial hypothalamus (DMH) can increase ventilation during sleep and reduce REM sleep time in db/db mice lacking leptin receptor LepR(b). Leptin had no effect on ventilation during non-REM sleep or CO2 production in these mice.
Article
Endocrinology & Metabolism
Eric A. Wilson, Hui Sun, Zhenzhong Cui, Marshal T. Jahnke, Mritunjay Pandey, Peter Metzger, Oksana Gavrilova, Min Chen, Lee S. Weinstein
Summary: The study highlights the importance of the G-protein subunits G(q)alpha and G(11)alpha in the dorsomedial hypothalamus for regulating energy balance, expenditure, thermoregulation, BAT function, and WAT browning.
AMERICAN JOURNAL OF PHYSIOLOGY-ENDOCRINOLOGY AND METABOLISM
(2021)
Article
Chemistry, Multidisciplinary
Yan Wei, Jun Chen, Xing Xu, Fan Li, Kun Wu, Yingying Jiang, Yuqing Rao, Chen Zhao, Wantao Chen, Xu Wang
Summary: The study demonstrates a critical role for Kdm6a in the regulation of H3k27me3 and its impact on Cry1 expression in the hypothalamus of diet-induced obesity mice. Inhibition of Kdm6a reduces body weight and stabilizes blood glucose homeostasis, suggesting Kdm6a as a potential drug target for obesity and metabolic disorders.
Article
Peripheral Vascular Disease
Seth W. Holwerda, Megan E. Gangwish, Rachel E. Luehrs, Virginia R. Nuckols, John P. Thyfault, John M. Miles, Gary L. Pierce
Summary: This study aimed to investigate the relationship between abdominal obesity and sympathetic nerve activity and blood pressure. The results showed that the transduction of sympathetic nerve activity to blood pressure was augmented in individuals with abdominal obesity and positively correlated with higher resting blood pressure.
JOURNAL OF HYPERTENSION
(2023)
Article
Biochemistry & Molecular Biology
Roberto B. Pontes, Erika E. Nishi, Renato O. Crajoinas, Maycon I. O. Milanez, Adriana C. C. Girardi, Ruy R. Campos, Cassia T. Bergamaschi
Summary: This study examined the effects of an acute increase in blood pressure and renal sympathetic nerve activity on sodium and water excretion and NHE3 activity. It was found that renal nerve stimulation independently decreased sodium and water excretion. However, when blood pressure was acutely increased during the stimulation, diuresis, natriuresis, and NHE3 activity inhibition were observed.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2023)
Article
Nutrition & Dietetics
Martin Regensburger, Laura Krumm, Manuel Alexander Schmidt, Andreas Schmid, Imke Tabea Spatz, Dominique Cornelius Marterstock, Christoph Kopp, Zacharias Kohl, Arnd Doerfler, Thomas Karrasch, Beate Winner, Jurgen Winkler
Summary: SPG11 patients exhibit altered body composition, adipokine levels, and hypothalamic volume, indicating a link between obesity and hypothalamic neurodegeneration in SPG11.
Article
Endocrinology & Metabolism
Zhigang Shi, Alyssa C. Bonillas, Jennifer Wong, Stephanie L. Padilla, Virginia L. Brooks
Summary: The study reveals that NPY in the hypothalamus suppresses sympathetic nerve activity in brown adipose tissue and influences heart rate and blood pressure via Y1R. Downstream pathways for BAT SNA may involve direct projections to the RPa and PVN.
JOURNAL OF NEUROENDOCRINOLOGY
(2021)
Review
Urology & Nephrology
Aneliya Parvanova, Elia Reseghetti, Manuela Abbate, Piero Ruggenenti
Summary: The prevalence of obesity has tripled over the past five decades, leading to an increased risk of hypertension. While the causal relationship between obesity and high blood pressure is well established, the detailed mechanisms for such association are still under research.
CLINICAL KIDNEY JOURNAL
(2023)
Article
Biochemistry & Molecular Biology
Joao A. B. Pedroso, Ivson B. da Silva, Thais T. Zampieri, Leonardo T. Totola, Thiago S. Moreira, Ana P. T. Taniguti, Gabriela P. Diniz, Maria Luiza M. Barreto-Chaves, Jose Donato
Summary: Increasing leptin sensitivity can have therapeutic effects against obesity, but it may also lead to cardiovascular and glucose metabolism issues.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2022)
Article
Biochemistry & Molecular Biology
Luciana da Costa Oliveira, Gustavo Paroschi Morais, Franciane Pereira de Oliveira, Milene Montavoni Mata, Allice Santos Cruz Veras, Alisson Luiz da Rocha, Lucila Leico Kagohara Elias, Giovana Rampazzo Teixeira, Camila de Moraes, Dennys E. Cintra, Eduardo R. Ropelle, Leandro P. de Moura, Jose R. Pauli, Ellen C. de Freitas, Rodrigo Rorato, Adelino Sanchez R. da Silva
Summary: Consuming a high-fat diet leads to hypothalamic inflammation and disrupts the leptin pathway, resulting in dysregulated hypothalamic neuronal activities and increased risk of obesity. Intermittent fasting and exercise training have been shown to effectively modulate hypothalamic inflammation and neuronal activity. However, it is unknown whether combining these interventions can better restore hypothalamic homeostasis in the presence of a high-fat diet.
JOURNAL OF NUTRITIONAL BIOCHEMISTRY
(2023)
Article
Biochemistry & Molecular Biology
Ting Gong, Ann C. Hashimoto, Alexandru R. Sasuclark, Vedbar S. Khadka, Alexandra Gurary, Matthew W. Pitts
Summary: SELENOM is a positive regulator of leptin signaling and thioredoxin antioxidant activity in the hypothalamus. Deficiency of SELENOM impairs downstream STAT3 phosphorylation and cytosolic calcium responses evoked by leptin treatment.
ANTIOXIDANTS & REDOX SIGNALING
(2021)
Review
Biochemistry & Molecular Biology
Anup Bhusal, Md Habibur Rahman, Kyoungho Suk
Summary: The hypothalamus is a critical brain region for energy homeostasis regulation, with recent studies highlighting the role of glial cells in addition to neurons. However, inflammatory activation of these cells under metabolic stress conditions contributes to various metabolic diseases, worsening the disease state.
CELLULAR AND MOLECULAR LIFE SCIENCES
(2022)
Article
Endocrinology & Metabolism
Santiago Guerra-Cantera, Laura M. Frago, Roberto Collado-Perez, Sandra Canelles, Purificacion Ros, Alejandra Freire-Regatillo, Maria Jimenez-Hernaiz, Vicente Barrios, Jesus Argente, Julie A. Chowen
Summary: Dietary intervention can impact metabolic hormones and glucose tolerance in male and female mice, with some parameters returning to normal levels after switching back to a standard diet, but with differences in the rate of recovery. Sex differences were also observed in the response to high fat diet and the switch to a normal diet, particularly in circulating levels of IGF2 and IGFBP2.
FRONTIERS IN ENDOCRINOLOGY
(2021)
Review
Peripheral Vascular Disease
Vanessa Oliveira, Anne E. Kwitek, Curt D. Sigmund, Lisa L. Morselli, Justin L. Grobe
Summary: Obesity is the major obstacle to improving cardiovascular health, involving changes in energy balance control that may lead to hypertension. Drug development targeting metabolism often leads to hypertension, but new research suggests different subtypes of AGRP neurons may have varying effects on feeding, metabolism, or blood pressure control.
Article
Psychology, Biological
Stephanie E. Simonds, Jack T. Pryor, Michael A. Cowley
PHYSIOLOGY & BEHAVIOR
(2018)
Correction
Endocrinology & Metabolism
Katrin Pfuhlmann, Sonja C. Schriever, Peter Baumann, Dhiraj G. Kabra, Luke Harrison, Sithandiwe E. Mazibuko-Mbeje, Raian E. Contreras, Eleni Kyriakou, Stephanie E. Simonds, Tony Tiganis, Michael A. Cowley, Stephen C. Woods, Martin Jastroch, Christoffer Clemmensen, Meri De Angelis, Karl-Werner Schramm, Michael Sattler, Ana C. Messias, Matthias H. Tschop, Paul T. Pfluger
Article
Cell Biology
Eglantine Balland, Weiyi Chen, Garron T. Dodd, Gregory Conductier, Roberto Coppari, Tony Tiganis, Michael A. Cowley
Article
Endocrinology & Metabolism
Stephanie E. Simonds, Jack T. Pryor, Frank H. Koegler, Alberte S. Buch-Rasmussen, Lauren E. Kelly, Kevin L. Grove, Michael A. Cowley
Article
Endocrinology & Metabolism
Eglantine Balland, Weiyi Chen, Tony Tiganis, Michael A. Cowley
NEUROENDOCRINOLOGY
(2019)
Article
Multidisciplinary Sciences
Tomris Mustafa, Qun Li, Lauren E. Kelly, Anne Gibbon, Irwin Ryan, Keisha Roffey, Stephanie Simonds, Michael A. Cowley, Mark W. Sleeman
Article
Multidisciplinary Sciences
Maria Findeisen, Tamara L. Allen, Darren C. Henstridge, Helene Kammoun, Amanda E. Brandon, Laurie L. Baggio, Kevin I. Watt, Martin Pal, Lena Cron, Emma Estevez, Christine Yang, Greg M. Kowalski, Liam O'Reilly, Casey Egan, Emily Sun, Le May Thai, Guy Krippner, Timothy E. Adams, Robert S. Lee, Joachim Groetzinger, Christoph Garbers, Steve Risis, Michael J. Kraakman, Natalie A. Mellet, James Sligar, Erica T. Kimber, Richard L. Young, Michael A. Cowley, Clinton R. Bruce, Peter J. Meikle, Paul A. Baldock, Paul Gregorevic, Trevor J. Biden, Gregory J. Cooney, Damien J. Keating, Daniel J. Drucker, Stefan Rose-John, Mark A. Febbraio
Article
Cell Biology
Garron T. Dodd, Chrysovalantou E. Xirouchaki, Matthew Eramo, Christina A. Mitchell, Zane B. Andrews, Belinda A. Henry, Michael A. Cowley, Tony Tiganis
Article
Endocrinology & Metabolism
Brandon L. Roberts, Baylin J. Bennett, Camdin M. Bennett, Julie M. Carroll, Louise S. Dalboge, Colin Hall, Wafa Hassouneh, Kristy M. Heppner, Melissa A. Kirigiti, Sarah R. Lindsley, Katherine G. Tennant, Cadence A. True, Andrew Whittle, Anitra C. Wolf, Charles T. Roberts, Mads Tang-Christensen, Mark W. Sleeman, Michael A. Cowley, Kevin L. Grove, Paul Kievit
MOLECULAR METABOLISM
(2019)
Article
Endocrinology & Metabolism
Zhengxiang Huang, Lili Huang, Chengjian Wang, Shanli Zhu, Xinzhou Qi, Yang Chen, Yanjun Zhang, Michael A. Cowley, Johannes D. Veldhuis, Chen Chen
JOURNAL OF ENDOCRINOLOGY
(2020)
Article
Biochemistry & Molecular Biology
Zhengxiang Huang, Xuehan Lu, Lili Huang, Chunhong Zhang, Johannes D. Veldhuis, Michael A. Cowley, Chen Chen
Summary: Stimulation of endogenous GH secretion by hexarelin can improve fat metabolism in obese mice by increasing lipolysis and lipid oxidation in adipose tissue, reducing de novo lipogenesis in the liver, and leading to decreased visceral and liver fat accumulation with improved insulin sensitivity, while maintaining stable levels of insulin and IGF-1.
Review
Endocrinology & Metabolism
Giles S. H. Yeo, Daniela Herrera Moro Chao, Anna-Maria Siegert, Zoe M. Koerperich, Mark D. Ericson, Stephanie E. Simonds, Courtney M. Larson, Serge Luquet, Iain Clarke, Shubh Sharma, Karine Clement, Michael A. Cowley, Carrie Haskell-Luevano, Lex Van der Ploeg, Roger A. H. Adan
Summary: Insights from human and mouse genetics have highlighted the central role of the brain leptin-melanocortin pathway in controlling mammalian food intake, leading to the approval of setmelanotide as a drug for individuals with severe obesity due to specific genetic deficiencies. This research provides a template for drug discovery in complex disorders, showing how a single gene target can eventually lead to the development of an approved drug after 25 years of study.
MOLECULAR METABOLISM
(2021)
Correction
Cell Biology
Kim Loh, Atsushi Fukushima, Xinmei Zhang, Sandra Galic, Dana Briggs, Pablo J. Enriori, Stephanie Simonds, Florian Wiede, Alexander Reichenbach, Christine Hauser, Natalie A. Sims, Kendra K. Bence, Sheng Zhang, Zhong-Yin Zhang, Barbara B. Kahn, Benjamin G. Neel, Zane B. Andrews, Michael A. Cowley, Tony Tiganis
