期刊
TRENDS IN NEUROSCIENCES
卷 31, 期 2, 页码 105-112出版社
ELSEVIER SCIENCE LONDON
DOI: 10.1016/j.tins.2007.11.006
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资金
- NIA NIH HHS [1 R01 AG021925, 1 R01 AG023742, 2 R37 AG08796] Funding Source: Medline
- NIMH NIH HHS [1 R01 MH47340] Funding Source: Medline
Intensive mapping of the essential cerebellar brain circuits for Pavlovian eyeblink conditioning appeared relatively complete by 2000, but new data indicate the need for additional differentiation of cerebellar regions and mechanisms coding delay and trace conditioning. This is especially important, as trace conditioning is an experimentally tractable model of declarative learning. The temporal gap in trace eyeblink conditioning may be bridged by forebrain regions through pontine-cerebellar nuclear connections that can bypass cerebellar cortex, whereas a cerebellar cortical Ion g-term-depression-like process appears to be required to support normal delay conditioning. Experiments focusing on the role of cerebellar cortex and deep nuclei in delay versus trace conditioning add perspective on brain substrates of these seemingly similar paradigms, which differ only by a brief stimulus-free time gap between conditioned and unconditioned stimuli. This temporal gap appears to impose forebrain dependencies and differentially engage different cerebellar circuitry during acquisition of conditioned responses.
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