期刊
TRENDS IN MOLECULAR MEDICINE
卷 20, 期 8, 页码 413-415出版社
ELSEVIER SCI LTD
DOI: 10.1016/j.molmed.2014.05.004
关键词
cancer; germline; genetics; personalized medicine; risk; somatic
In recent years there have been major advances in the knowledge of the genetic alterations that drive cancer susceptibility and progression. However, the molecular links between these alteration levels (i.e., germline for susceptibility and somatic for progression) remain mostly unknown. Here, the potential of integrating germline and somatic data for a comprehensive and personalized cancer medicine is discussed.
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