Review
Biochemistry & Molecular Biology
Anais Paris, Nina Tardif, Marie-Dominique Galibert, Sebastien Corre
Summary: The aryl hydrocarbon receptor (AhR) is a crucial transcription factor involved in various biological activities, including tumorigenesis. Its role in cancer is complex, encompassing both pro- and anti-tumorigenic activities. The expression and activity levels of AhR vary in different tumors and patients, making it challenging to understand the specific roles of AhR ligands.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2021)
Review
Biochemistry & Molecular Biology
Maria Konoshenko, Yuriy Lansukhay, Sergey Krasilnikov, Pavel Laktionov
Summary: This review summarizes and analyzes the data on miRNAs associated with lung cancer cisplatin chemotherapy response, and identifies 12 miRNAs with high predictive potential. The study contributes to predicting lung cancer cisplatin sensitivity or resistance, as well as the development of more effective cisplatin combination therapy.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2022)
Review
Oncology
Angeliki Andrikopoulou, Almog Shalit, Eleni Zografos, Konstantinos Koutsoukos, Anna-Maria Korakiti, Michalis Liontos, Meletios-Athanasios Dimopoulos, Flora Zagouri
Summary: MicroRNAs play a crucial role in sensitivity and resistance to CDK4/6 inhibitors, with some microRNAs serving as predictive biomarkers. MicroRNA-targeted therapy may potentially enhance sensitivity to CDK4/6 inhibition.
Article
Genetics & Heredity
Mark S. Gibson, Claudia Noronha-Estima, Margarida Gama-Carvalho
Summary: MicroRNAs have the potential to be used as therapeutic agents for cancer and HIV by reprogramming cellular metabolism. The field of immunometabolism has provided insights into the relationship between immune cell metabolism and function. Modulating miRNA activity could be an effective approach for restricting HIV replication and eliminating infected cells.
Article
Oncology
Ataollah Rajabnejad, Florin Vaida, Mark Valasek, Saqib Razzaque, Paul Fanta, Santiago Horgan, Michael Bouvet, Andrew M. Lowy, Kaitlyn J. Kelly
Summary: This study found that 46% of patients with locally advanced gastric cancer did not have a histologic response to therapy. Histology of signet ring cell carcinoma and possibly race were associated with treatment effect grade.
JOURNAL OF SURGICAL ONCOLOGY
(2021)
Article
Surgery
Giampaolo Perri, Laura Prakash, Huamin Wang, Priya Bhosale, Gauri R. Varadhachary, Robert Wolff, David Fogelman, Michael Overman, Shubham Pant, Milind Javle, Eugene Koay, Joseph Herman, Michael Kim, Naruhiko Ikoma, Ching-Wei Tzeng, Jeffrey E. Lee, Matthew H. G. Katz
Summary: This study aimed to identify potential radiologic and serologic markers of pancreatic tumor response to therapy, using pathologic major response (pMR) as the objective endpoint. Patients who experienced pMR were found to have low posttreatment CA 19-9 levels, RECIST partial response, and reduction in tumor volume. These findings could help inform the delivery of preoperative therapy to patients with PDAC.
Article
Medicine, Research & Experimental
M. Toledano-Fonseca, M. A. Gomez-Espana, E. Elez, C. Gravalos, P. Garcia-Alfonso, R. Rodriguez, F. Losa, I. Ales Diaz, B. Grana, M. Valladares-Ayerbes, M. V. Garcia-Ortiz, E. Polo, M. Salgado, F. Rivera, M. J. Safont, A. Salud, A. Ruiz-Casado, J. M. Tabernero, M. C. Riesco, A. Rodriguez-Ariza, E. Aranda
Summary: This study examined the profiles of circulating microRNAs (miRNAs) in metastatic colorectal cancer patients and found that certain miRNAs, such as hsa-miR-33b-5p, could serve as valuable biomarkers for predicting response to therapy and disease progression. Combining the levels of circulating VEGF-A with miR-33b-5p further improved the stratification of patients.
BIOMEDICINE & PHARMACOTHERAPY
(2023)
Article
Oncology
Anna Plotkin, Ekaterina Olkhov-Mitsel, Sharon Nofech-Mozes, Bojana Djordjevic, Jelena Mirkovic, Madeline Fitzpatrick, Adriana Krizova, Nicole J. Look Hong
Summary: This study evaluated the costs associated with four approaches to classifying endometrial cancer and found that histomolecular classification had the highest cost. Therefore, informed decision-making is needed when implementing molecular classification in clinical practice.
GYNECOLOGIC ONCOLOGY
(2023)
Article
Clinical Neurology
Sasa R. Filipovic, Aleksandra Kacar, Sladjan Milanovic, Milos R. Ljubisavljevic
Summary: The study found that neurophysiological measures related to cortical excitability may be associated with clinical response to dopaminergic medication in Parkinson's disease patients, potentially leading to personalized therapy.
FRONTIERS IN NEUROLOGY
(2021)
Article
Health Care Sciences & Services
Devon K. Check, Joseph G. Winger, Kelley A. Jones, Tamara J. Somers
Summary: This study analyzed predictors of response to pain coping skills training in cancer patients and found that education level, cancer type, and marital status were associated with reductions in pain severity and interference.
JOURNAL OF PAIN AND SYMPTOM MANAGEMENT
(2021)
Article
Gastroenterology & Hepatology
Lillian Wang, Kristin C. Mara, Karthik Ravi, Tsung-Teh Wu, Thomas C. Smyrk, David A. Katzka, Jeffrey A. Alexander
Summary: This retrospective study aimed to determine the response rates and predictors of histologic response to elimination diets in adults with EoE. The results showed that a higher pre-SFED EREF score was associated with dietary non-response to SFED. Additionally, poor correlation between symptoms and histologic flares was observed, and ExSFED identified additional dietary responders. Therefore, histologic confirmation should be sought before committing patients to lifelong dietary changes.
ALIMENTARY PHARMACOLOGY & THERAPEUTICS
(2022)
Review
Biochemistry & Molecular Biology
Minyeoung Kweon, Jae Yeon Kim, Ji Hye Jun, Gi Jin Kim
Summary: The paper explores the therapeutic potential of stem cell treatment for liver diseases, highlighting the advantages of MSCs in treating various hepatic conditions and the potential of miRNA as a biomarker for monitoring treatment efficacy.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2021)
Article
Multidisciplinary Sciences
Ian Schillebeeckx, Jon Earls, Kevin C. Flanagan, Jeffrey Hiken, Alex Bode, Jon R. Armstrong, David N. Messina, Douglas Adkins, Jessica Ley, Ilaria Alborelli, Philip Jermann, Jarret Glasscock
Summary: Anti-PD-1 therapy can provide long-term benefits for some patients, but the current PD-L1 test is not an accurate predictor of response. To improve this, researchers have developed a method called T Cell Subtype Profiling (TCSP) that accurately characterizes the abundance of T cell subtypes using RNA models. This method is analytically valid and has shown promising results in predicting response to anti-PD-1 therapy in multiple cancer types.
SCIENTIFIC REPORTS
(2022)
Article
Multidisciplinary Sciences
Ofir Shorer, Keren Yizhak
Summary: The metabolism of immune cells in the tumor microenvironment plays a crucial role in cancer patient response to immune checkpoint inhibitors (ICI). This study used single-cell RNA-seq data to analyze the metabolic genes of immune cells in the TME of cancer patients treated with ICI. The results showed that metabolic states are associated with patient response, and a metabolic predictor based on gene signatures could effectively differentiate responding and non-responding patients.
Review
Endocrinology & Metabolism
Jingyu Song, Jiaxin Wang, Kang Liu, Wenchao Xu, Taotao Sun, Jihong Liu
Summary: Erectile dysfunction, a common male sexual dysfunction disease, is predicted to affect 322 million individuals worldwide by 2025. The pathogenesis of ED is complex and current treatments options are limited. Recent studies have highlighted the significant role of miRNAs in ED, suggesting their potential as therapeutic targets for the disease.
FRONTIERS IN ENDOCRINOLOGY
(2022)
Article
Pathology
Pei Hui, Stefan M. Gysler, Mohamed Uduman, Taiwo A. Togun, Daniel E. Prado, Christine E. Brambs, Sunitha Nallur, Peter E. Schwartz, Thomas J. Rutherford, Alessandro D. Santin, Joanne B. Weidhaas, Elena S. Ratner
Article
Oncology
Jemima J. Dorairaj, David W. Salzman, Deirdre Wall, Tiffany Rounds, Carina Preskill, Catherine A. W. Sullivan, Robert Lindner, Catherine Curran, Kim Lezon-Geyda, Terri McVeigh, Lyndsay Harris, John Newell, Michael J. Kerin, Marie Wood, Nicola Miller, Joanne B. Weidhaas
Article
Biochemistry & Molecular Biology
A. J. Venkatakrishnan, Tilman Flock, Daniel Estevez Prado, Matt E. Oates, Julian Gough, M. Madan Babu
CURRENT OPINION IN STRUCTURAL BIOLOGY
(2014)
Review
Oncology
David K. Gaffney, Anuja Jhingran, Lorraine Portelance, Akila Viswanathan, Tracey Schefter, Joanne Weidhaas, William Small
INTERNATIONAL JOURNAL OF GYNECOLOGICAL CANCER
(2014)
Article
Oncology
Paul E. Wallner, Mitchell S. Anscher, Christopher A. Barker, Michael Bassetti, Robert G. Bristow, Yong I. Cha, Adam P. Dicker, Silvia C. Formenti, Edward E. Graves, Stephen M. Hahn, Tom K. Hei, Alec C. Kimmelman, David G. Kirsch, Kevin R. Kozak, Theodore S. Lawrence, Brian Marples, William H. McBride, Ross B. Mikkelsen, Catherine C. Park, Joanne B. Weidhaas, Anthony L. Zietman, Michael Steinberg
INTERNATIONAL JOURNAL OF RADIATION ONCOLOGY BIOLOGY PHYSICS
(2014)
Article
Biochemistry & Molecular Biology
Jianhong Chen, Milagros D. Morrical, Katherine A. Donigan, Joanne B. Weidhaas, Joann B. Sweasy, April M. Averill, Jennifer A. Tomczak, Scott W. Morrical
NUCLEIC ACIDS RESEARCH
(2015)
Article
Biochemistry & Molecular Biology
X. Chen, T. Paranjape, C. Stahlhut, T. McVeigh, F. Keane, S. Nallur, N. Miller, M. Kerin, Y. Deng, X. Yao, H. Zhao, J. B. Weidhaas, F. J. Slack
Article
Multidisciplinary Sciences
Larissa J. Lee, Elena Ratner, Mohamed Uduman, Kathryn Winter, Marta Boeke, Kathryn M. Greven, Stephanie King, Thomas W. Burke, Kelly Underhill, Harold Kim, Raleigh J. Boulware, Herbert Yu, Vinita Parkash, Lingeng Lu, David Gaffney, Adam P. Dicker, Joanne Weidhaas
Review
Oncology
Ye Yuan, Joanne B. Weidhaas
MOLECULAR ONCOLOGY
(2019)
Article
Oncology
Joanne Weidhaas, Nicholas Marco, Aaron W. Scheffler, Anusha Kalbasi, Kirk Wilenius, Emily Rietdorf, Jaya Gill, Mara Heilig, Caroline Desler, Robert K. Chin, Tania Kaprealian, Susan McCloskey, Ann Raldow, Naga P. Raja, Santosh Kesari, Jose Carrillo, Alexandra Drakaki, Mark Scholz, Donatello Telesca
Summary: The study found that a germline microRNA-based biomarker signature can accurately predict grade 2 and higher immune-related adverse effects (irAEs) to anti-PD1/PDL1 therapy in a pan-cancer manner. RAC1 was identified as a significant biomarker of toxicity, predicting a greater than ninefold increased risk of toxicity, but was not associated with response to anti-PD1/PDL1 therapy.
JOURNAL FOR IMMUNOTHERAPY OF CANCER
(2022)
Article
Oncology
Amar U. Kishan, Nicholas Marco, Ting Martin Ma, Michael L. Steinberg, Ankush Sachdeva, Minsong Cao, Leslie K. Ballas, Emily Rietdorf, Donatello Telesca, Joanne B. Weidhaas
Summary: The predictors of genitourinary toxicity after post-prostatectomy radiotherapy are still unknown. A previously defined germline DNA signature (PROSTOX) has shown to be able to predict late grade>=2 genitourinary toxicity after intact prostate stereotactic body radiotherapy. We investigate whether PROSTOX can predict toxicity among patients receiving post-prostatectomy SBRT in a phase II clinical trial.
CLINICAL AND TRANSLATIONAL RADIATION ONCOLOGY
(2023)
Article
Oncology
Zirong Li, Ann C. Raldow, Joanne B. Weidhaas, Qichao Zhou, X. Sharon Qi
Summary: Locally advanced rectal cancer (LARC) presents a challenge in terms of identifying individualized response to radiation therapy. This study proposes a framework using CBCT scans for accurate and robust assessment of treatment response, allowing for early detection and monitoring of patient response.
Article
Oncology
Joanne B. Weidhaas, Chen Hu, Ritsuko Komaki, Gregory A. Masters, George R. Blumenschein, Joe Y. Chang, Bo Lu, Adam P. Dicker, Jeffrey A. Bogart, Yolanda I. Garces, Samir Narayan, Clifford G. Robinson, Vivek S. Kavadi, Joel S. Greenberger, Christopher D. Koprowski, James Welsh, Elizabeth M. Gore, Robert M. Macrae, Rebecca Paulus, Jeffrey D. Bradley
Summary: Although overall survival advantage was not observed in KRAS-variant patients, there is a potential impact of cetuximab for this genetic subset of patients. In contrast, cetuximab seems to harm non-variant patients. These findings further support the importance of genetic patient selection in trials studying the addition of systemic agents to radiotherapy.
CANCER RESEARCH COMMUNICATIONS
(2023)
Review
Biochemistry & Molecular Biology
Poonam Malhotra, Graham H. Read, Joanne B. Weidhaas
Meeting Abstract
Biochemistry & Molecular Biology
Daniel Estevez Prado, Tilman Flock, Alexander S. Hauser, Ramanujan S. Hegde, M. Madan Babu