期刊
TRENDS IN MOLECULAR MEDICINE
卷 16, 期 7, 页码 295-302出版社
ELSEVIER SCI LTD
DOI: 10.1016/j.molmed.2010.04.005
关键词
-
资金
- Lundbeck Foundation [R31-2008-2391] Funding Source: researchfish
Autophagy is an evolutionarily conserved lysosomal self-digestion process essential for cellular homeostasis, differentiation and survival. As an adaptive response, it protects organisms against a wide range of pathologies, including cancer, infection, neurodegeneration, heart disease and ageing. Thus, compounds activating autophagy could have great potential in the prevention of common diseases. Interestingly, recent data link autophagy to two functions of the active form of vitamin D (VD): the induction of cancer cell death and the clearance of Mycobacterium tuberculosis in macrophages. Because VD deficiency is associated with many pathologies resembling those induced by defective autophagy, it is tempting to speculate that autophagy plays a more general role in the multiple health-promoting effects of VD.
作者
我是这篇论文的作者
点击您的名字以认领此论文并将其添加到您的个人资料中。
推荐
暂无数据