期刊
TRENDS IN MOLECULAR MEDICINE
卷 16, 期 6, 页码 277-286出版社
ELSEVIER SCI LTD
DOI: 10.1016/j.molmed.2010.04.003
关键词
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资金
- Agence Nationale pour la Recherche (ANR)
- European Union [ERC 2008-AdG-233130-HEPCENT]
- INTERREG-IV-2009-FEDER-Hepato-Regio-Net
- Fondation FRM BNP-Paribas
- ANRS [2007/306, 2008/354]
- INCA
- Inserm
- Else-Kroner Fresenius Stiftung [P17//07//A83/06]
- Ligue Contre le Cancer [CA 06/12]
- German Competence Network for Viral Hepatitis
- German Ministry of Education and Research (BMBF) [01 KI 0437, 01 HI 0787]
- [LSHM-CT-2004-503359]
With a global burden of 170 million chronically infected patients and a major cause of liver cirrhosis and hepatocellular carcinoma, hepatitis C virus (HCV) is a major public health challenge. Recent discoveries of viral and cellular factors mediating virus-host interactions have allowed scientists to uncover the key molecular mechanisms of viral infection and escape from innate and adaptive immune responses. These include the discovery of tight junction proteins as entry factors and micro-RNA-122, cyclophilins and lipoproteins as host factors or virus translation, replication and production. Further-more, global genetic analyses have identified IL-28B as a genetic factor associated with the outcome of HCV injection. These discoveries markedly advance the understanding of the molecular pathogenesis of HCV infection and uncover novel targets for urgently needed antiviral strategies.
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