Editorial Material
Neurosciences
Gabrielle M. Mey, Tara M. DeSilva
Summary: In this study, Sun et al. demonstrate the role of EndoMT in triggering breakdown of the blood-CNS barrier in the pathogenesis of multiple sclerosis.
Article
Biochemistry & Molecular Biology
George E. G. Kluck, Jeong-Ah Yoo, Emmanuel H. Sakarya, Bernardo L. Trigatti
Summary: Research has shown an inverse correlation between HDL levels and severity of COVID-19, with its ability to enhance or suppress virus infection potentially linked to the expression of the SR-B1 receptor.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2021)
Article
Critical Care Medicine
Alexander T. Fields, Zachary A. Matthay, Brenda Nunez-Garcia, Ellicott C. Matthay, Roland J. Bainton, Rachael A. Callcut, Lucy Z. Kornblith
Summary: This study found that soluble factors in plasma from injured patients have different effects on the aggregation of healthy platelets, with plasma from shock patients impairing aggregation and plasma from patients with severe injury but without shock enhancing aggregation.
Review
Urology & Nephrology
Weijun Huang, LaTonya J. Hickson, Alfonso Eirin, James L. Kirkland, Lilach O. Lerman
Summary: Cellular senescence plays important roles in tissue remodeling, but excessive senescence may lead to cancer and age-related diseases. It involves cell-cycle arrest and the release of inflammatory cytokines with autocrine, paracrine, and endocrine activities. Therapeutic interventions targeting cellular senescence have shown potential benefits in extending lifespan and reducing tissue injury.
NATURE REVIEWS NEPHROLOGY
(2022)
Article
Public, Environmental & Occupational Health
Timothy L. Lash, Thomas P. Ahern, Lindsay J. Collin, Matthew P. Fox, Richard F. MacLehose
Summary: The importance of bias analysis in epidemiologic research is highlighted in the text, with a mention of the lack of quantitative estimates of bias impacts in reports despite the availability of methods and tools. Three suboptimal bias analysis examples are identified, and common shortcomings in these examples are summarized.
AMERICAN JOURNAL OF EPIDEMIOLOGY
(2021)
Article
Chemistry, Multidisciplinary
Fan Chen, Jinpeng Liu, Robert M. Flight, Kassandra J. Naughton, Alexsandr Lukyanchuk, Abigail R. Edgin, Xiulong Song, Haikuo Zhang, Kwok-Kin Wong, Hunter N. B. Moseley, Chi Wang, Christine F. Brainson
Summary: This study presents a method for using third-generation TKIs to treat EGFR-driven lung cancer, and describes how tumors with distinct epigenetic states can be obtained through different cell types. It was found that tumors of different origins retain their epigenetic differences and have distinct drug vulnerabilities.
Editorial Material
Hematology
Georg Stary
Summary: In this study published in Blood, van Halteren et al have identified an immune cell signature that is associated with the onset of acute graft-versus-host disease (aGVHD) and the response to first- and second-line therapy.(1)
Review
Biochemistry & Molecular Biology
Carlos Jimenez-Cortegana, Ana Lopez-Saavedra, Flora Sanchez-Jimenez, Antonio Perez-Perez, Jesus Castineiras, Juan A. Virizuela-Echaburu, Luis de la Cruz-Merino, Victor Sanchez-Margalet
Summary: Leptin plays a crucial role in regulating basal metabolism and food intake, and its association with obesity has been linked to various types of cancer. While it may have a detrimental role in cancer initiation and progression, recent evidence suggests that it could also potentially enhance immune response in cancer patients, highlighting its dual role in oncology.
Review
Biochemistry & Molecular Biology
Mark Bates, Bashir M. Mohamed, Mark P. Ward, Tanya E. Kelly, Roisin O'Connor, Victoria Malone, Robert Brooks, Doug Brooks, Stavros Selemidis, Cara Martin, Sharon O'Toole, John J. O'Leary
Summary: This review provides an overview of circulating tumour cells (CTCs), which are highly lethal cancer cells and play a crucial role in cancer metastasis. CTCs have clinical utility as diagnostic, prognostic, and therapeutic targets. However, their complex biology and the challenges involved in their isolation and identification hinder their clinical translation. CTCs are capable of forming microemboli composed of diverse populations, which interact with other circulating cells and may increase their malignant potential. These microemboli represent a prognostically important subset, but the presence of phenotypic gradients adds complexity to the situation.
BIOCHIMICA ET BIOPHYSICA ACTA-REVIEWS ON CANCER
(2023)
Editorial Material
Cell Biology
Sally Winther, Mette Trauelsen, Thue W. Schwartz
Summary: Recent study shows that succinate, a metabolite in the TCA cycle, acts as a signal of metabolic stress and its accumulation in thermogenic fat can drive liver inflammation and fibrosis through the succinate receptor SUCNR1.
Editorial Material
Cell Biology
Nadine Martin, Anda Huna, David Bernard
Summary: Cellular senescence plays a critical role in various physiological and pathological contexts. Recent studies have highlighted the dual effects that eliminating senescent endothelial cells can have on health span. This raises questions about the current development of senolytics as a therapeutic strategy.
TRENDS IN CELL BIOLOGY
(2021)
Review
Computer Science, Hardware & Architecture
Bharat Dwivedi, Debarati Sen, Sandip Chakraborty
Summary: This survey examines the changes in cellular network architecture in recent years, emphasizing the advantages and challenges brought by these changes. The new architecture aims to make the cellular network more flexible, scalable, distributed, and programmable by separating components, incorporating virtualized infrastructure, and separating control and data planes. The goal is to enhance network capacity, reliability, connectivity, QoS, and QoE. Upgrading the current architecture is necessary due to the projected increase in cellular traffic in the next generation. Reducing latency through the separation of units and further division is crucial for achieving high data rates.
JOURNAL OF NETWORK AND COMPUTER APPLICATIONS
(2022)
Review
Oncology
Irem Ozel, Inga Duerig, Maksim Domnich, Stephan Lang, Ekaterina Pylaeva, Jadwiga Jablonska
Summary: Tumor angiogenesis is a critical step in cancer progression, and neutrophils have been found to play an important role in this process. This review summarizes the pro-angiogenic functions of neutrophils and discusses the potential for targeting these cells in anti-cancer therapy.
Review
Oncology
Zhuo Georgia Chen, Nabil F. Saba, Yong Teng
Summary: FAT1, one of the most frequently mutated genes in cancer, has potential as a target or prognostic biomarker in cancer treatment. Its function in cancer progression seems to be cancer-type specific and requires further clarification. This review summarizes the recent literature on the role of FAT1 in cancer, including its involvement in cell-cell contact, mitochondrial respiration, and epithelial-mesenchymal transition.
JOURNAL OF EXPERIMENTAL & CLINICAL CANCER RESEARCH
(2022)
Article
Oncology
Guobin Liao, Jun Tang, Jianying Bai
Summary: Esophageal squamous cell carcinoma (ESCC) is a highly malignant cancer with poor prognosis, and its development is based on the classical view of cancer development from stem cell origin and multistep progression. Recent advancements in large-scale and single-cell sequencing technologies, along with transgenic lineage tracing in mouse models, have provided a more detailed understanding of the heterogeneity and early clonal evolution of esophageal stem cells and ESCC. This review discusses the potential relationship between esophageal basal-layer stem cells and cells of ESCC origin, as well as the role of NOTCH1 mutants in the early clonal evolution of ESCCs.
Article
Oncology
J. Etchin, J. Montero, A. Berezovskaya, B. T. Le, A. Kentsis, A. L. Christie, A. S. Conway, W. C. Chen, C. Reed, M. R. Mansour, C. E. L. Ng, S. Adamia, S. J. Rodig, I. A. Galinsky, R. M. Stone, B. Klebanov, Y. Landesman, M. Kauffman, S. Shacham, A. L. Kung, J. C. Y. Wang, A. Letai, A. T. Look
Article
Oncology
Eric R. Lechman, Bernhard Gentner, Stanley W. K. Ng, Erwin M. Schoof, Peter van Galen, James A. Kennedy, Silvia Nucera, Fabio Ciceri, Kerstin B. Kaufmann, Naoya Takayama, Stephanie M. Dobson, Aaron Trotman-Grant, Gabriela Krivdova, Janneke Elzinga, Amanda Mitchell, Bjorn Nilsson, Karin G. Hermans, Kolja Eppert, Rene Marke, Ruth Isserlin, Veronique Voisin, Gary D. Bader, Peter W. Zandstra, Todd R. Golub, Benjamin L. Ebert, Jun Lu, Mark Minden, Jean C. Y. Wang, Luigi Naldini, John E. Dick
Correction
Oncology
Eric R. Lechman, Bernhard Gentner, Stanley W. K. Ng, Erwin M. Schoof, Peter van Galen, James A. Kennedy, Silvia Nucera, Fabio Ciceri, Kerstin B. Kaufmann, Naoya Takayama, Stephanie M. Dobson, Aaron Trotman-Grant, Gabriela Krivdova, Janneke Elzinga, Amanda Mitchell, Bjoern Nilsson, Karin G. Hermans, Kolja Eppert, Rene Marke, Ruth Isserlin, Veronique Voisin, Gary D. Bader, Peter W. Zandstra, Todd R. Golub, Benjamin L. Ebert, Jun Lu, Mark Minden, Jean C. Y. Wang, Luigi Naldini, John E. Dick
Article
Oncology
Penka S. Petrova, Natasja Nielsen Viller, Mark Wong, Xinli Pang, Gloria H. Y. Lin, Karen Dodge, Vien Chai, Hui Chen, Vivian Lee, Violetta House, Noel T. Vigo, Debbie Jin, Tapfuma Mutukura, Marilyse Charbonneau, Tran Truong, Stephane Viau, Lisa D. Johnson, Emma Linderoth, Eric L. Sievers, Saman Maleki Vareki, Rene Figueredo, Macarena Pampillo, James Koropatnick, Suzanne Trudel, Nathan Mbong, Liqing Jin, Jean C. Y. Wang, Robert A. Uger
CLINICAL CANCER RESEARCH
(2017)
Article
Oncology
J. Etchin, A. Berezovskaya, A. S. Conway, I. A. Galinsky, R. M. Stone, E. Baloglu, W. Senapedis, Y. Landesman, M. Kauffman, S. Shacham, J. C. Y. Wang, A. T. Look
Article
Medicine, Research & Experimental
Margaret Nieborowska-Skorska, Katherine Sullivan, Yashodhara Dasgupta, Paulina Podszywalow-Bartnicka, Grazyna Hoser, Silvia Maifrede, Esteban Martinez, Daniela Di Marcantonio, Elisabeth Bolton-Gillespie, Kimberly Cramer-Morales, Jaewong Lee, Min Li, Artur Slupianek, Daniel Gritsyuk, Sabine Cerny-Reiterer, Ilona Seferynska, Tomasz Stoklosa, Lars Bullinger, Huaqing Zhao, Vera Gorbunova, Katarzyna Piwocka, Peter Valent, Curt I. Civin, Markus Muschen, John E. Dick, Jean C. Y. Wang, Smita Bhatia, Ravi Bhatia, Kolja Eppert, Mark D. Minden, Stephen M. Sykes, Tomasz Skorski
JOURNAL OF CLINICAL INVESTIGATION
(2017)
Article
Multidisciplinary Sciences
Liran I. Shlush, Amanda Mitchell, Lawrence Heisler, Sagi Abelson, Stanley W. K. Ng, Aaron Trotman-Grant, Jessie J. F. Medeiros, Abilasha Rao-Bhatia, Ivana Jaciw-Zurakowsky, Rene Marke, Jessica L. McLeod, Monica Doedens, Gary Bader, Veronique Voisin, ChangJiang Xu, John D. McPherson, Thomas J. Hudson, Jean C. Y. Wang, Mark D. Minden, John E. Dick
Review
Hematology
Jean C. Y. Wang
TRANSFUSION MEDICINE REVIEWS
(2018)
Article
Oncology
Isabelle Laverdiere, Meaghan Boileau, Andrea L. Neumann, Heloise Frison, Amanda Mitchell, Stanley W. K. Ng, Jean C. Y. Wang, Mark D. Minden, Kolja Eppert
BLOOD CANCER JOURNAL
(2018)
Review
Hematology
Sagi Abelson, Jean C. Y. Wang
CURRENT OPINION IN HEMATOLOGY
(2018)
Article
Oncology
Nicolas Duployez, Alice Marceau-Renaut, Celine Villenet, Arnaud Petit, Alexandra Rousseau, Stanley W. K. Ng, Agnes Paquet, Fanny Gonzales, Adeline Barthelemy, Frederic Lepretre, Nicolas Pottier, Brigitte Nelken, Gerard Michel, Andre Baruchel, Yves Bertrand, Guy Leverger, Helene Lapillonne, Martin Figeac, John E. Dick, Jean C. Y. Wang, Claude Preudhomme, Meyling Cheok
Article
Multidisciplinary Sciences
Sagi Abelson, Grace Collord, Stanley W. K. Ng, Omer Weissbrod, Netta Mendelson Cohen, Elisabeth Niemeyer, Noam Barda, Philip C. Zuzarte, Lawrence Heisler, Yogi Sundaravadanam, Robert Luben, Shabina Hayat, Ting Ting Wang, Zhen Zhao, Julia Cirlan, Trevor J. Pugh, David Soave, Karen Ng, Calli Latimer, Claire Hardy, Keiran Raine, David Jones, Diana Hoult, Abigail Britten, John D. McPherson, Mattias Johansson, Faridah Mbabaali, Jenna Eagles, Jessica K. Millers, Danielle Pasternack, Lee Timms, Paul Krzyzanowski, Philip Awadalla, Rui Costa, Eran Segal, Scott Bratman, Philip Beer, Sam Behjati, Inigo Martincorena, Jean C. Y. Wang, Kristian M. Bowles, J. Ramon Quiros, Anna Karakatsani, Carlo La Vecchia, Antonia Trichopoulou, Elena Salamanca-Fernandez, Jose M. Huerta, Aurelio Barricarte, Ruth C. Travis, Rosario Tumino, Giovanna Masala, Heiner Boeing, Salvatore Panico, Rudolf Kaaks, Alwin Kraemer, Sabina Sieri, Elio Riboli, Paolo Vineis, Matthieu Foll, James McKay, Silvia Polidoro, Nuria Sala, Kay-Tee Khaw, Roel Vermeulen, Peter J. Campbell, Elli Papaemmanuil, Mark D. Minden, Amos Tanay, Ran D. Balicer, Nicholas J. Wareham, Moritz Gerstung, John E. Dick, Paul Brennan, George S. Vassiliou, Liran Shlush
Article
Hematology
Kerstin B. Kaufmann, Laura Garcia-Prat, Qiang Liu, Stanley W. K. Ng, Shin-Ichiro Takayanagi, Amanda Mitchell, Erno Wienholds, Peter van Galen, Christian A. Cumbaa, Mike J. Tsay, Chiara Pastrello, Elvin Wagenblast, Gabriela Krivdova, Mark D. Minden, Eric R. Lechman, Sasan Zandi, Igor Jurisica, Jean C. Y. Wang, Stephanie Z. Xie, John E. Dick
Letter
Hematology
Oleksandr Galkin, Jessica McLeod, James A. Kennedy, Liqing Jin, Nathan Mbong, Mark Wong, Robert A. Uger, Mark D. Minden, Jayne S. Danska, Jean C. Y. Wang
Article
Hematology
Jenny M. Ho, Stephanie M. Dobson, Veronique Voisin, Jessica McLeod, James A. Kennedy, Amanda Mitchell, Liqing Jin, Kolja Eppert, Gary Bader, Mark D. Minden, John E. Dick, Jean C. Y. Wang
