期刊
TRENDS IN MOLECULAR MEDICINE
卷 14, 期 9, 页码 381-388出版社
ELSEVIER SCI LTD
DOI: 10.1016/j.molmed.2008.07.002
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资金
- Cancer Research UK Funding Source: Medline
- Medical Research Council [MC_U105359878] Funding Source: Medline
- MRC [MC_U105359878] Funding Source: UKRI
- Alzheimers Research UK [ART-PPG2006A-5] Funding Source: researchfish
Tumour necrosis factor-alpha (TNF-alpha) is a proinflammatory cytokine, whereas nerve growth factor (NGF) is a neurotrophin that can promote neural cell survival, differentiation and maturation. However, recent papers indicate that TNF-alpha has a pivotal role in fate decisions of neural cells in normal noninflammatory conditions, whereas NGF contributes to maintenance of inflammation. Although these observations suggest a close relationship between NGF and TNF-alpha signalling, crosstalk between these factors is not fully understood. In this Opinion article, we review recent reports regarding possible crosstalk between NGF and TNF-alpha and we propose a positive-feedback loop of their expression. We discuss the possible mechanisms by which disturbance of the crosstalk could contribute to diseases such as cancer and Alzheimer's disease.
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