期刊
TRENDS IN MICROBIOLOGY
卷 21, 期 4, 页码 187-195出版社
ELSEVIER SCI LTD
DOI: 10.1016/j.tim.2013.01.004
关键词
Streptococcus pneumoniae; reactive oxygen species; hydrogen peroxide; oxidative stress defence
资金
- University Medical Centre Groningen (UMCG)
Streptococcus pneumoniae, an aerotolerant anaerobe, is an important human pathogen that regularly encounters toxic oxygen radicals from the atmosphere and from the host metabolism and immune system. Additionally, S. pneumoniae produces large amounts of H2O2 as a byproduct of its metabolism, which contributes to its virulence but also has adverse effects on its biology. Understanding how S. pneumoniae defends against oxidative stress is far from complete, but it is apparent that it does not follow the current paradigm of having canonical enzymes to detoxify oxygen radicals or homologues of typical oxidative stress responsive global regulators. We will give an overview of how S. pneumoniae copes with oxygen radicals. Furthermore, we draw parallels with other pathogenic streptococcal species and provide future research perspectives.
作者
我是这篇论文的作者
点击您的名字以认领此论文并将其添加到您的个人资料中。
推荐
暂无数据