期刊
TRENDS IN MICROBIOLOGY
卷 21, 期 8, 页码 364-371出版社
ELSEVIER SCI LTD
DOI: 10.1016/j.tim.2013.05.008
关键词
biofilm; chronic infection; innate immune response; c-di-GMP; STING; PAMPs; type I interferon; cGAS
资金
- Spanish Ministry of Economy and Competitiveness [BIO2011-30503-C02-02, AGL2011-23954, BFU2011-23222]
- ERA-NET Pathogenomics [PIM2010EPA-00606]
- Departamento de Innovacion [IIQ14066.RI1, IIM13329.RI1]
- Departamento de Salud, Gobierno de Navarra [Resolucion 1312/2010]
- Spanish Ministry of Science and Innovation 'Ramon y Cajal' contract
Biofilm development is recognized as a major virulence factor underlying most chronic bacterial infections. When a biofilm community is established, planktonic cells growing in the surroundings of a tissue switch to a sessile lifestyle and start producing a biofilm matrix. The initial steps of in vivo biofilm development are poorly characterized and difficult to assess experimentally. A great amount of in vitro evidence has shown that accumulation of high levels of cyclic dinucleotides (c-di-NMPs) is the most prevalent hallmark governing the initiation of biofilm development by bacteria. As mentioned above, recent studies also link detection of c-di-NMPs by host cells with the activation of a type I interferon immune response against bacterial infections. We discuss here c-di-NMP signaling and the host immune response in the context of the initial steps of in vivo biofilm development.
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