期刊
TRENDS IN MICROBIOLOGY
卷 19, 期 10, 页码 472-482出版社
ELSEVIER SCI LTD
DOI: 10.1016/j.tim.2011.07.006
关键词
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资金
- National Institutes of Health
- Crohn's and Colitis Foundation of America
- Bill and Melinda Gates Foundation
- Howard Hughes Medical Institute
High-throughput sequencing technologies provide new opportunities to address longstanding questions about habitat adaptation in microbial organisms. How have microbes managed to adapt to such a wide range of environments, and what genomic features allow for such adaptation? We review recent large-scale studies of habitat adaptation, with emphasis on those that utilize phylogenetic techniques. On the basis of current trends, we summarize methodological challenges faced by investigators, and the tools, techniques and analytical approaches available to overcome them. Phylogenetic approaches and detailed information about each environmental sample will be crucial as the ability to collect genome sequences continues to expand.
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