期刊
TRENDS IN MICROBIOLOGY
卷 19, 期 6, 页码 257-262出版社
ELSEVIER SCI LTD
DOI: 10.1016/j.tim.2011.03.002
关键词
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资金
- Institut Pasteur
- CNRS
- La Ligue Contre le Cancer
- Association pour la Recherche sur le Cancer (ARC)
- Agence Nationale de Recherche (ANR)
- Agence Nationale de Recherche sur le SIDA (ANRS)
- Fundacao para a Ciencia e a Tecnologia, Portugal
- European Commission
- EMBO
The recent finding that the human T-cell leukemia virus type 1 (HTLV-1) encases itself in a carbohydrate-rich adhesive extracellular 'cocoon', which enables its efficient and protected transfer between cells, unveiled a new infectious entity and a novel mechanism of viral transmission. These HTLV-1 structures are observed at the surface of T cells from HTLV-1-infected patients and are reminiscent of bacterial biofilms. The virus controls the synthesis of the matrix, which surrounds the virions and attaches them to the T cell surface. We propose that, similar to bacterial biofilms, viral biofilms could represent 'viral communities' with enhanced infectious capacity and improved spread compared with 'free' viral particles, and might constitute a key reservoir for chronic infections.
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