期刊
TRENDS IN MICROBIOLOGY
卷 17, 期 8, 页码 371-377出版社
ELSEVIER SCI LTD
DOI: 10.1016/j.tim.2009.05.006
关键词
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资金
- National Institutes of Health/NIAID GLRCE
- Emerging Infectious Disease Research Program [1U54-AI-057153]
- National Institutes of Health [1R01AI073558, R43AI064959-02]
- Binational Agricultural Research and Development [US-3829-06 R]
Brucella is an important zoonotic pathogen for which no human vaccine exists. In an infected host, Brucella resides in macrophages but must coordinate expression of multiple virulence factors for successful cell entry and trafficking to acquire this replicative niche. Brucella responds to environmental signals to regulate virulence strategies that circumvent or blunt the host immune response. The Brucella quorum sensing system is a nexus of control for several Brucella virulence factors including flagellar genes and the type IV secretion system. Other sensory transduction systems, such as BvrRS and the newly described LOV-HK, sense environmental factors to control virulence. Here, we examine the contributions of various regulatory systems to Brucella virulence.
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