期刊
TRENDS IN MICROBIOLOGY
卷 16, 期 8, 页码 388-396出版社
ELSEVIER SCI LTD
DOI: 10.1016/j.tim.2008.05.006
关键词
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资金
- National Institutes of Health [AI052151]
- United States Department of Agriculture [2005-35201-15330]
Listeria monocytogenes can respond rapidly to changing environmental conditions, as illustrated by its ability to transition from a saprophyte to an orally transmitted facultative intracellular pathogen. Differential associations between various alternative sigma factors and a core RNA polymerase provide a transcriptional mechanism for regulating bacterial gene expression that is crucial for survival in rapidly changing conditions. Alternative sigma factors are key components of complex L. monocytogenes regulatory networks that include multiple transcriptional regulators of stress-response and virulence genes, regulation of genes encoding other regulators, and regulation of small RNAs. In this article, the contributions of various or factors to L. monocytogenes stress response and virulence are described.
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