期刊
TRENDS IN MICROBIOLOGY
卷 16, 期 12, 页码 605-611出版社
ELSEVIER SCI LTD
DOI: 10.1016/j.tim.2008.08.010
关键词
-
资金
- US N.I.H. [R01 A1049120, R01 A1052056, R24 RR015371, R24 RR016038]
HIV infection, once established, is never cleared. Rare individuals do, however, control viral replication to low levels. These successful immune responses are primarily linked to certain class I MHC alleles (MHC-I). Because of this association, many AIDS vaccines in development are designed to generate virus-specific CD8+ T cells. The Merck STEP phase 2b efficacy trial of one such vaccine was recently halted, and declared a failure. Thus, basic questions regarding what constitutes an effective T cell response and how such responses could be elicited by vaccination remain open. The best animal model available to explore such issues is simian immunodeficiency virus infection of rhesus macaques, which serves as the primary proving ground for AIDS vaccines.
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