期刊
TRENDS IN IMMUNOLOGY
卷 34, 期 6, 页码 299-306出版社
ELSEVIER SCI LTD
DOI: 10.1016/j.it.2013.03.003
关键词
-
类别
资金
- Division of Intramural Research, National Institute of Allergy and Infectious Diseases, National Institutes of Health
Barrier surfaces are home to a vast population of commensal organisms that together encode millions of proteins; each of them possessing several potential foreign antigens. Regulation of immune responses to this enormous antigenic load represents a tremendous challenge for the immune system. Tissues exposed to commensals have developed elaborate systems of regulation including specialized populations of resident lymphocytes that maintain barrier function and limit potential responses to commensal antigens. However, in settings of infection and inflammation these regulatory mechanisms are compromised and specific effector responses against commensal bacteria can develop. This review discusses the circumstances controlling the fate of commensal specific T cells and how dysregulation of these responses could lead to severe pathological outcomes.
作者
我是这篇论文的作者
点击您的名字以认领此论文并将其添加到您的个人资料中。
推荐
暂无数据