期刊
TRENDS IN IMMUNOLOGY
卷 31, 期 3, 页码 91-96出版社
ELSEVIER SCI LTD
DOI: 10.1016/j.it.2009.11.005
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资金
- Dutch Cancer Society [2007-3917]
- Netherlands Organization for Scientific Research [817 02 001]
Fungal pattern-recognition receptors (F-PRRs), including C-type lectins, Toll-like receptors, scavenger receptors and Fc/complement receptors, are crucial for inducing anti-fungal immune responses by antigen-presenting cells. The recent identification of specific F-PRR interactions with tetraspanins has shed new light on the functioning of F-PRRs in the cell membrane and subsequent downstream signaling. Tetraspanins are small four-transmembrane proteins that can assemble immune receptors and signaling molecules into functional membrane microdomains. Here, we discuss the implications of this novel type of interaction between F-PRRs and tetraspanins in different subsets of antigen-presenting cells. We postulate that upon fungal binding tetraspanins modulate the function of F-PRRs by their recruitment into tetraspanin microdomains, leading to immune activation or tolerance.
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