期刊
TRENDS IN IMMUNOLOGY
卷 31, 期 8, 页码 295-302出版社
ELSEVIER SCI LTD
DOI: 10.1016/j.it.2010.05.008
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资金
- Canadian Institutes of Health Research (CIHR)
- Canadian Cancer Society Research Institute
- Howard Hughes Medical Institute
The signaling lymphocytic activation molecule (SLAM)associated protein (SAP) family of adaptors couples SLAM family receptors to activating intracellular signaling pathways that drive immune cell activation or differentiation. In the absence of SAP family adaptors, SLAM family receptors become inhibitory, possibly through coupling to the Src-homology-2-containing phosphatases. This switch-of-function of SLAM family receptors provides an explanation for the severe immune dysfunctions observed in humans with X-linked lymphoproliferative disease due to SAP deficiency, as well as in genetically engineered mice that lack SAP family adaptors.
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