期刊
TRENDS IN IMMUNOLOGY
卷 30, 期 4, 页码 182-189出版社
ELSEVIER SCI LTD
DOI: 10.1016/j.it.2009.01.003
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资金
- Engineering and Physical Science Research Council, Pfizer
- Cambridge Isotope Laboratories
- Gilead Sciences
- CK Gas Products Ltd
- Medical Research Council, Research Councils UK
- Wellcome Trust
- Research Council for Earth and Life Sciences (ALW)
- Netherlands Organization for Scientific Research (NWO) [836.07.002]
- US Department of Energy
- EPSRC [EP/G003130/1] Funding Source: UKRI
- MRC [G0601072, G0500628] Funding Source: UKRI
- Engineering and Physical Sciences Research Council [EP/G003130/1] Funding Source: researchfish
- Medical Research Council [G0601072, G0500628] Funding Source: researchfish
Quantitative understanding of immunology requires the development of experimental and mathematical techniques for estimation of rates of division and death of lymphocytes under different conditions. Here, we review the advantages and limitations of several labelling methods that are currently used to quantify turnover of lymphocytes in vivo. In addition to highlighting insights into lymphocyte kinetics which have recently been gained thanks to the development of novel techniques, we discuss important directions for future experimental and theoretical work in the field of lymphocyte turnover.
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