期刊
TRENDS IN GENETICS
卷 29, 期 8, 页码 469-478出版社
ELSEVIER SCIENCE LONDON
DOI: 10.1016/j.tig.2013.03.003
关键词
vitamin auxotrophy; evolution; symbiosis; pseudogenes; comparative genomics; algae
资金
- Biotechnology and Biological Sciences Research Council [BB/I013164/1]
- Biotechnology and Biological Sciences Research Council [BB/I013164/1] Funding Source: researchfish
- Natural Environment Research Council [pml010004] Funding Source: researchfish
- BBSRC [BB/I013164/1] Funding Source: UKRI
- NERC [pml010004] Funding Source: UKRI
The advent of modern genomics has provided an unparalleled opportunity to consider the gene complement of an organism, and scrutinize metabolic pathways that are no longer active. This approach has led to an increasing number of reports of vitamin-associated pathway deterioration, with many indicating that independent geneloss events of one or a few key genes have led to vitamin auxotrophy. Nonfunctional unitary pseudogenes belonging to these pathways are found in several species, demonstrating that these are recent evolutionary processes. Here, we examine the commonalities in the cellular roles and metabolism of vitamins that might have led to these losses. The complex pattern of vitamin auxotrophy across the eukaryotic tree of life is intimately connected with the interdependence between organisms. The importance of this process in terms of shaping communities on the one hand, and facilitating symbioses between organisms on the other, is only just beginning to be recognized.
作者
我是这篇论文的作者
点击您的名字以认领此论文并将其添加到您的个人资料中。
推荐
暂无数据