期刊
TRENDS IN ENDOCRINOLOGY AND METABOLISM
卷 25, 期 8, 页码 378-380出版社
ELSEVIER SCIENCE LONDON
DOI: 10.1016/j.tem.2014.05.006
关键词
type 1 diabetes; islet cell transplantation; beta cells; induced pluripotent stem cell; embryonic stem cell
资金
- NIDDK NIH HHS [R01 DK074656] Funding Source: Medline
Replacement of insulin-producing cells is a promising therapy for the restoration of the beta cell mass that is destroyed in patients with type 1 diabetes (T1D). However, the use of large amounts of islets per transplant, coupled with the scarcity of donor tissue, diminishes its feasibility. Here we briefly discuss current progress in developing ideal functional beta cells as well as the rationale for developing renewable sources of insulin-producing cells that can be transplanted.
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