期刊
TRENDS IN ENDOCRINOLOGY AND METABOLISM
卷 23, 期 10, 页码 501-508出版社
ELSEVIER SCIENCE LONDON
DOI: 10.1016/j.tem.2012.05.006
关键词
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资金
- INSERM [1036]
- University Joseph Fourier
- Commissariat a l'Energie Atomique (DSV/iRTSV/BCI)
- Region Rhone-Alpes [CIBLE-2008]
Endocrine gland-derived vascular endothelial growth factor (EG-VEGF), also named prokineticin 1, is the canonical member of the prokineticin family. Numerous reports suggest a direct involvement of this peptide in normal and pathological reproductive processes. Recent advances propose EG-VEGF as a key endocrine factor that controls many aspects of placental development and suggest its involvement in the development of pre-eclampsia (PE), the most threatening pathology of human pregnancy. This review describes the finely tuned action and regulation of EG-VEGF throughout human pregnancy, argues for its clinical relevance as a potential diagnostic marker of the onset of PE, and discusses future research directions for therapeutic targeting of EG-VEGF.
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