期刊
TRENDS IN ENDOCRINOLOGY AND METABOLISM
卷 23, 期 10, 页码 533-543出版社
ELSEVIER SCIENCE LONDON
DOI: 10.1016/j.tem.2012.07.001
关键词
clomiphene citrate; metformin; polycystic ovary syndrome; ovulation induction; infertility; systematic review
Though widely used, there is uncertainty about the effectiveness and adverse effects of metformin and clomiphene citrate (CC) for infertility in polycystic ovary syndrome (PCOS). A systematic review (SR) of the best available evidence suggests that both CC and metformin are better than placebo for increasing ovulation and pregnancy rates, but CC is more effective than metformin for ovulation, pregnancy and live-birth rates, in PCOS patients with body mass index (BMI) >30. A combination of CC and metformin is superior to either metformin alone or CC alone, depending on the BMI and CC sensitivity of the patient. This SR provides key messages to guide clinicians and consumers on the use of these interventions in different subgroups of women with PCOS.
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