期刊
ALGAL RESEARCH-BIOMASS BIOFUELS AND BIOPRODUCTS
卷 11, 期 -, 页码 263-270出版社
ELSEVIER SCIENCE BV
DOI: 10.1016/j.algal.2015.07.002
关键词
Carbon fixation; Cyanobacteria; Genetic engineering; MOG pathway; PEPc; RuBisCO; Synechocystis PCC 6803
资金
- Swedish Energy Agency
- Knut and Alice Wallenberg Foundation (project MoSE)
- Nordic Energy Research (project AquaFEED)
Cyanobacteria, gram-negative prokaryotic microorganisms, perform oxygenic photosynthesis with a photosynthetic machinery similar to higher plants which includes ribulose 1,5-bisphosphate carboxylase/oxygenase (RuBisCO) as the main CO2-fixing enzyme. Currently, there is a growing interest to use cyanobacteria as photosynthetic microbial cell factories for the direct production of solar fuels or other compounds of human interest. However, rates and efficiencies to produce e.g. biofuels are still very low. The amount of available fixed carbon for the synthesis of desired product(s) may be one of the limiting steps. This contribution reviews CO2-fixation in cyanobacteria with focus on CO2-concentrating mechanisms, RuBisCO, phosphoenolpyruvate carboxylase and other carboxylases, engineering approaches for increased carbon fixation, and finally the synthetic malonyl-CoA-oxaloacetate-glyoxylate pathways. (C) 2015 Elsevier B.V. All rights reserved.
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