Article
Clinical Neurology
Yuanzhi Xu, Ahmed Mohyeldin, Maximiliano Alberto Nunez, Ayoze Doniz-Gonzalez, Vera Vigo, Aaron A. Cohen-Gadol, Juan C. Fernandez-Miranda
Summary: The authors investigated the microvascular anatomy of the hippocampus and its implications for medial temporal tumor surgery, revealing the anatomical variability of the arterial supply and venous drainage of the hippocampus. The study found rich anastomoses between hippocampal arteries and highlighted the importance of understanding the vascular variability and network of the hippocampus for surgery in this region, including anterior temporal lobectomy with amygdalohippocampectomy and transsylvian selective amygdalohippocampectomy.
JOURNAL OF NEUROSURGERY
(2021)
Article
Computer Science, Artificial Intelligence
Yuguo Liu, Wenyu Chen, Hanwen Liu, Yun Zhang, Malu Zhang, Hong Qu
Summary: In this study, we explore three spiking neuron models to post-process the original dense word embeddings and test the sparse temporal codes generated on several tasks involving word-level and sentence-level semantics. The experimental results demonstrate that our sparse binary word representations can capture semantic information as well as or even better than the original word embeddings, while requiring less storage. These methods provide a robust representation foundation of language in terms of neuronal activities, which could potentially be applied to more complex natural language tasks under neuromorphic computing systems.
IEEE TRANSACTIONS ON NEURAL NETWORKS AND LEARNING SYSTEMS
(2023)
Article
Neurosciences
Michael A. Rosario, Kathryn L. Kern, Shiraz Mumtaz, Thomas W. Storer, Karin Schon
Summary: Cardiorespiratory fitness has a significant impact on neurocognitive health, especially the hippocampal memory system. This study found a correlation between cardiorespiratory fitness and left medial temporal lobe neocortical regions in young adults, which is related to their subjective sense of direction.
EUROPEAN JOURNAL OF NEUROSCIENCE
(2023)
Article
Clinical Neurology
Paul A. Yushkevich, Monica Munoz Lopez, Maria Mercedes Iniguez de Onzono Martin, Ranjit Ittyerah, Sydney Lim, Sadhana Ravikumar, Madigan L. Bedard, Stephen Pickup, Weixia Liu, Jiancong Wang, Ling Yu Hung, Jade Lasserve, Nicolas Vergnet, Long Xie, Mengjin Dong, Salena Cui, Lauren McCollum, John L. Robinson, Theresa Schuck, Robin de Flores, Murray Grossman, M. Dylan Tisdall, Karthik Prabhakaran, Gabor Mizsei, Sandhitsu R. Das, Emilio Artacho-Perula, Mari'a Del Mar Arroyo Jimenez, Mari'a Pilar Marcos Raba, Francisco Javier Molina Romero, Sandra Cebada Sanchez, Jose Carlos Delgado Gonzalez, Carlos De la Rosa-Prieto, Marta Corcoles Parada, Edward B. Lee, John Q. Trojanowski, Daniel T. Ohm, Laura E. M. Wisse, David A. Wolk, David J. Irwin, Ricardo Insausti
Summary: This study utilized ex vivo MRI and dense serial histological imaging to construct three-dimensional quantitative maps of neurofibrillary tangle burden in the medial temporal lobe, revealing significant variation along different anatomical regions. The findings provide valuable insights into the distribution of this neurodegenerative pathology and may support the development and validation of neuroimaging biomarkers.
Review
Clinical Neurology
Nadim Jaafar, Amar Bhatt, Alexandra Eid, Mohamad Z. Koubeissi
Summary: Some surgical failures after temporal lobe epilepsy surgery may be caused by the presence of extratemporal epileptogenic zones, particularly in the medial parietal lobe. Seizures originating from this area may not cause obvious symptoms before spreading to the temporal lobe.
FRONTIERS IN NEUROLOGY
(2022)
Article
Neurosciences
Robin de Flores, Sandhitsu R. Das, Long Xie, Laura E. M. Wisse, Xueying Lyu, Preya Shah, Paul A. Yushkevich, David A. Wolk
Summary: This study reveals the relationship between the medial temporal lobe and the anterior-temporal and posterior-medial networks, and explores the vulnerability of these networks to proteinopathies in Alzheimer's disease. The results show that the atrophy of distinct subregions in the medial temporal lobe propagates differently within the anterior-temporal and posterior-medial networks. Additionally, these networks are differentially associated with relative tau and amyloid burden.
JOURNAL OF NEUROSCIENCE
(2022)
Article
Multidisciplinary Sciences
Mikkel Elle Lepperod, Ane Charlotte Christensen, Kristian Kinden Lensjo, Alessio Paolo Buccino, Jai Yu, Marianne Fyhn, Torkel Hafting
Summary: The study shows that optogenetic activation of specific cells surrounding grid cells in the medial entorhinal cortex can influence their spatial activity patterns but not their velocity coding. Phase precession of grid cells is abolished, but speed information is still transmitted through rate coding of individual neurons.
Article
Behavioral Sciences
Bohee Lee, June Sic Kim, Chun Kee Chung
Summary: Working memory is crucial for goal-directed behavior, and the frontoparietal network and medial temporal lobe play important roles in working memory. Through intracranial electroencephalography recording, it was found that low-frequency power in the frontal lobe and medial temporal lobe increased and sustained throughout the working memory task, while parietal alpha power peaked during memory operation. Furthermore, there was a positive correlation in the alpha band between the medial temporal lobe and the parietal lobe during memory operation.
Article
Medicine, General & Internal
Xiao-Ming Yan, Cui-Ping Xu, Yu-Ping Wang, Kai Ma, Tao Yu, Xiao-Hua Zhang, Xi Zhang, Run-Shi Gao, Guo-Jun Zhang, Yong-Jie Li
Summary: Patients with medial temporal lobe seizures had more favorable surgical outcomes and distinct SEEG features compared to patients with lateral temporal lobe seizures.
CHINESE MEDICAL JOURNAL
(2021)
Article
Clinical Neurology
Cedric Dusanter, Marion Houot, Marie Mere, Marisa Denos, Severine Samson, Bastien Herlin, Vincent Navarro, Sophie Dupont
Summary: The aim of this study was to evaluate the specific effects of antiseizure medications (ASMs) on cognition in a group of refractory patients with epilepsy. The results showed that the type and number of ASMs had a significant impact on cognition, especially topiramate (TPM) and sodium valproate (VPA). Based on the findings, it is recommended to reduce the total number of drugs received and avoid medications with unfavorable cognitive profiles.
EUROPEAN JOURNAL OF NEUROLOGY
(2023)
Article
Biology
Susanna Ukonaho, Simon N. N. Chapman, Michael Briga, Virpi Lummaa
Summary: The presence of grandmothers can improve the survival rates of their grandchildren, specifically in terms of lethal infections and accidents. However, this effect is not mediated through increased or earlier vaccination. These findings have important implications for public health, societal development, and human life-history evolution.
PROCEEDINGS OF THE ROYAL SOCIETY B-BIOLOGICAL SCIENCES
(2023)
Article
Biology
Weizhen Xie, Marcus Cappiello, Michael A. Yassa, Edward Ester, Kareem A. Zaghloul, Weiwei Zhang, Floris P. de Lange
Summary: Classic models consider working memory and long-term memory as distinct mental faculties that are supported by different neural mechanisms. Recent evidence suggests that the medial temporal lobe may be involved in working memory, but the specific role of the entorhinal-DG/CA3 pathway in supporting precise item-specific working memory remains unclear.
Article
Neurosciences
Jingyuan Ren, Furong Huang, Chuanji Gao, Jarrod Gott, Sarah F. Schoch, Shaozheng Qin, Martin Dresler, Jing Luo
Summary: This study investigated the impact of novel stimuli on the left and right medial temporal lobes, revealing different activations in response to novel designs of different usefulness. The findings suggest that the left medial temporal lobe is predominantly involved in usefulness processing, while the right medial temporal lobe is predominantly involved in novelty processing. Additionally, the left parahippocampal gyrus showed stronger connectivity with the anterior cingulate cortex when responding to novel useless designs, while the right parahippocampal gyrus showed stronger connectivity with the amygdala, midbrain, and hippocampus.
Article
Neurosciences
Dengrong Jiang, Peiying Liu, Zixuan Lin, Kaisha Hazel, George Pottanat, Emma Lucke, Abhay Moghekar, Jay J. Pillai, Hanzhang Lu
Summary: The study aims to develop an MRI technique to non-invasively measure the MTL-OEF. The method measures the venous oxygenation in the basal veins of Rosenthal, which can estimate the MTL-OEF. The results show that the AS-aTRUPC MRI technique has the potential to be a disease biomarker.
Article
Anatomy & Morphology
Sara Seoane, Cristian Modrono, Jose Luis Gonzalez-Mora, Niels Janssen
Summary: By analyzing a high spatial resolution 7T rsfMRI dataset, we found the associations between the medial temporal lobe (MTL) and different resting-state networks. Specifically, different sub-regions of the MTL were associated with different resting-state networks such as the default mode, visual, and dorsal attention networks. These findings provide new insights into the role of the MTL in resting-state networks.
BRAIN STRUCTURE & FUNCTION
(2022)
Article
Neurosciences
Song-Lin Ding, Joshua J. Royall, Susan M. Sunkin, Lydia Ng, Benjamin A. C. Facer, Phil Lesnar, Angie Guillozet-Bongaarts, Bergen McMurray, Aaron Szafer, Tim A. Dolbeare, Allison Stevens, Lee Tirrell, Thomas Benner, Shiella Caldejon, Rachel A. Dalley, Nick Dee, Christopher Lau, Julie Nyhus, Melissa Reding, Zackery L. Riley, David Sandman, Elaine Shen, Andre van der Kouwe, Ani Varjabedian, Michelle Write, Lilla Zollei, Chinh Dang, James A. Knowles, Christof Koch, John W. Phillips, Nenad Sestan, Paul Wohnoutka, H. Ronald Zielke, John G. Hohmann, Allan R. Jones, Amy Bernard, Michael J. Hawrylycz, Patrick R. Hof, Bruce Fischl, Ed S. Lein
JOURNAL OF COMPARATIVE NEUROLOGY
(2016)
Article
Neurosciences
Quanxin Wang, Lydia Ng, Julie A. Harris, David Feng, Yang Li, Josh J. Royall, Seung Wook Oh, Amy Bernard, Susan M. Sunkin, Christof Koch, Hongkui Zeng
JOURNAL OF COMPARATIVE NEUROLOGY
(2017)
Article
Ophthalmology
Hagar Gelbard-Sagiv, Nathan Faivre, Liad Mudrik, Christof Koch
Article
Neurosciences
Bosiljka Tasic, Vilas Menon, Thuc Nghi Nguyen, Tae Kyung Kim, Tim Jarsky, Zizhen Yao, Boaz Levi, Lucas T. Gray, Staci A. Sorensen, Tim Dolbeare, Darren Bertagnolli, Jeff Goldy, Nadiya Shapovalova, Sheana Parry, Changkyu Lee, Kimberly Smith, Amy Bernard, Linda Madisen, Susan M. Sunkin, Michael Hawrylycz, Christof Koch, Hongkui Zeng
NATURE NEUROSCIENCE
(2016)
Review
Neurosciences
Giulio Tononi, Melanie Boly, Marcello Massimini, Christof Koch
NATURE REVIEWS NEUROSCIENCE
(2016)
Review
Neurosciences
Christof Koch, Marcello Massimini, Melanie Boly, Giulio Tononi
NATURE REVIEWS NEUROSCIENCE
(2016)
Article
Multidisciplinary Sciences
Michael Hawrylycz, Costas Anastassiou, Anton Arkhipov, Jim Berg, Michael Buice, Nicholas Cain, Nathan W. Gouwens, Sergey Gratiy, Ramakrishnan Iyer, Jung Hoon Lee, Stefan Mihalas, Catalin Mitelut, Shawn Olsen, R. Clay Reid, Corinne Teeter, Saskia de Vries, Jack Waters, Hongkui Zeng, Christof Koch
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA
(2016)
Article
Multidisciplinary Sciences
Lu Li, Benjamin Ouellette, William A. Stoy, Emma J. Garren, Tanya L. Daigle, Craig R. Forest, Christof Koch, Hongkui Zeng
NATURE COMMUNICATIONS
(2017)
Article
Multidisciplinary Sciences
Nathan W. Gouwens, Jim Berg, David Feng, Staci A. Sorensen, Hongkui Zeng, Michael J. Hawrylycz, Christof Koch, Anton Arkhipov
NATURE COMMUNICATIONS
(2018)
Editorial Material
Psychology, Biological
Christof Koch
NATURE HUMAN BEHAVIOUR
(2020)
Article
Biochemical Research Methods
Brian Hu, Marina E. Garrett, Peter A. Groblewski, Douglas R. Ollerenshaw, Jiaqi Shang, Kate Roll, Sahar Manavi, Christof Koch, Shawn R. Olsen, Stefan Mihalas
Summary: This study compares the predictions of persistent neural activity and synaptic mechanisms in maintaining short-term memories with neural and behavioral measurements. The results suggest that a feedforward neural network with short-term synaptic depression shows behavior patterns and errors more similar to mice compared to a recurrent neural network.
PLOS COMPUTATIONAL BIOLOGY
(2021)
Article
Biochemical Research Methods
Jerome Lecoq, Michael Oliver, Joshua H. Siegle, Natalia Orlova, Peter Ledochowitsch, Christof Koch
Summary: DeepInterpolation is a general-purpose denoising algorithm that significantly increases the signal-to-noise ratio without sacrificing spatial or temporal resolution, allowing for extraction of more information from the processed data.
Editorial Material
Neurosciences
Christof Koch, Karel Svoboda, Amy Bernard, Michele A. Basso, Anne K. Churchland, Adrienne L. Fairhall, Peter A. Groblewski, Jerome A. Lecoq, Zachary F. Mainen, Mackenzie W. Mathis, Shawn R. Olsen, John W. Phillips, Alexandre Pouget, Shreya Saxena, Josh H. Siegle, Anthony M. Zador
Summary: This article proposes the establishment of centralized brain observatories for large-scale recordings of neural activity in animals, aiming to advance reproducible systems neuroscience and democratize access to advanced tools and data.
Editorial Material
Multidisciplinary Sciences
Christof Koch
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA
(2023)
Article
Biology
Leslie D. Claar, Irene Rembado, Jacqulyn R. Kuyat, Simone Russo, Lydia C. Marks, Shawn R. Olsen, Christof Koch
Summary: This study predicts the presence of consciousness in volunteers and patients by stimulating the brain and analyzing the EEG responses. The researchers conducted similar experiments on mice and observed different patterns of cortical and thalamic responses during wakefulness, running, and anesthesia.