期刊
TRENDS IN CELL BIOLOGY
卷 24, 期 5, 页码 294-302出版社
ELSEVIER SCIENCE LONDON
DOI: 10.1016/j.tcb.2013.10.008
关键词
cardiac; enhancers; gene regulation; GWAS; heart
类别
Advances in genome research have provided an unprecedented opportunity to investigate the function of non-coding DNA regulatory regions that control transcription. Large-scale studies have recently identified hundreds of thousands of distal enhancer elements; their discovery has revealed new insights into the mechanistic details of how tissue-specific gene expression patterns are established and maintained during development. Emerging evidence indicates that lineage-specific transcription factors and chromatin regulators coordinate the activation of distal enhancers to ensure robust control of gene expression programs in a cell type-specific manner. We discuss recent progress in the field and emphasize examples related to the cardiac lineage, where possible, as a model for understanding the contribution of enhancer biology to development and how disruption of enhancer function leads to disease.
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