期刊
TRENDS IN CELL BIOLOGY
卷 24, 期 11, 页码 619-631出版社
ELSEVIER SCIENCE LONDON
DOI: 10.1016/j.tcb.2014.06.004
关键词
chromatin remodeling; nucleosome binding; SWR-C; 1N080-C; Arp subcomplexes
类别
资金
- Human Frontiers Science Program
- Swiss National Science Foundation
- Framework Program (FP7) Marie Curie Intra European Fellowship
- Novartis Research Foundation
Virtually all DNA-dependent processes require selective and controlled access to the DNA sequence. Governing this access are sophisticated molecular machines, nudeosome remodelers, which regulate the composition and structure of chromatin, allowing conversion from open to closed states. In most cases these multisubunit remodelers operate in concert to organize chromatin structure by depositing, moving, evicting, or selectively altering nucleosomes in an ATP-dependent manner. Despite sharing a conserved domain architecture, chromatin remodelers differ significantly in how they bind to their nucleosomal substrates. Recent structural studies link specific interactions between nucleosomes and remodelers to the diverse tasks they carry out. We review here insights into the modular organization of the IN080 family of nucleosome remodelers. Understanding their structural diversity will help to shed light on how these related ATPases modify their nucleosomal substrates.
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