期刊
TRENDS IN CELL BIOLOGY
卷 23, 期 10, 页码 476-483出版社
ELSEVIER SCIENCE LONDON
DOI: 10.1016/j.tcb.2013.05.003
关键词
Cdc42; Rac; Rop; GEF; GAP
类别
资金
- National Institutes of Health/National Institute of General Medical Sciences grant [GM62300]
Cortical domains are often specified by the local accumulation of active GTPases. Such domains can arise through spontaneous symmetry-breaking, suggesting that GTPase accumulation occurs via positive feedback. Here, we focus on recent advances in fungal and plant cell models - where new work suggests that polarity-controlling GTPases develop only one 'front' because GTPase clusters engage in a winner-takes-all competition. However, in some circumstances two or more GTPase domains can coexist, and the basis for the switch from competition to coexistence remains an open question. Polarity GTPases can undergo oscillatory clustering and dispersal, suggesting that these systems contain negative feedback. Negative feedback may prevent polarity clusters from spreading too far, regulate the balance between competition and coexistence, and provide directional flexibility for cells tracking gradients.
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