期刊
TRENDS IN CELL BIOLOGY
卷 23, 期 5, 页码 227-233出版社
ELSEVIER SCIENCE LONDON
DOI: 10.1016/j.tcb.2012.12.001
关键词
formin; actin; polarized growth; PTEN; microtubules; cytoskeleton
类别
资金
- Plant Biology Graduate Program at the University of MA Amherst
- NSF [MCB-0747231]
- David and Lucille Packard Foundation
- Div Of Molecular and Cellular Bioscience
- Direct For Biological Sciences [0747231] Funding Source: National Science Foundation
In plants, the actin cytoskeleton plays a fundamental role in intracellular transport, cell growth, and morphology. Formins are central regulators of actin polymerization and actin-based processes in many eukaryotes. Plants have a diverse family of formins and this diversity arose early in land plant evolution, probably deriving from family expansion and domain acquisition. Recently, formins from different plant lineages have been studied and the focus of these studies is beginning to shift from biochemical characterization to in vivo function. In vivo studies have shown that distinct biochemical activities confer specific cellular functions. Despite these differences, many plant formins have in common a direct link to the plasma membrane, suggesting that formins in plants are important links between the plasma membrane and actin remodeling.
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