Review
Cell Biology
Fang Liu, Yanfen Shi, Zuolong Liu, Ziyi Li, Wei Xu
Summary: Evidence has shown that miRNAs are crucial in the tumorigenesis and progression of various cancers, including gastric cancer, with miR-10a and miR-10b identified as key players in gastric carcinogenesis. Targeting the miR-10 family could be a promising approach for treating gastric cancer, as it regulates multiple aspects of cancer cell behavior and various compounds have shown antitumor activity by targeting these miRNAs.
Review
Pharmacology & Pharmacy
Meng-Nan Liu, Gang Luo, Wan-Jiao Gao, Si-Jin Yang, Hua Zhou
Summary: miR-29 plays a crucial role in cardiovascular disease (CVD), particularly in maintaining arterial integrity and regulating atherosclerosis. Studies have shown the potential of miR-29 as a potential marker for prevention, treatment, and prognostic observation in CVD.
PHARMACOLOGICAL RESEARCH
(2021)
Review
Biochemistry & Molecular Biology
Masahiro Horita, Colin Farquharson, Louise A. Stephen
Summary: This review summarizes the differential expression patterns and functional roles of the miR-29 family in diseases such as osteoarthritis, osteoporosis, cardiorenal, and immune disease, highlighting their therapeutic potential. Further research is needed to identify the precise mechanisms of the miR-29 family in these diseases and their potential in therapeutics.
JOURNAL OF CELLULAR BIOCHEMISTRY
(2021)
Review
Cell Biology
Zijun Xie, Chenming Zhong, Shiwei Duan
Summary: miR-1269a and miR-1269b play important roles in the occurrence and development of multiple cancers. They have the potential to be diagnostic and prognostic markers for cancer. Further research can focus on elucidating more upstream and downstream genes and exploring the clinical application value of miR-1269a and miR-1269b.
FRONTIERS IN CELL AND DEVELOPMENTAL BIOLOGY
(2022)
Review
Cell Biology
Xue Sun, Gebang Wang, Wenting Luo, Hui Gu, Wei Ma, Xiaowei Wei, Dan Liu, Shanshan Jia, Songying Cao, Yu Wang, Zhengwei Yuan
Summary: Cardiovascular diseases are the leading cause of death worldwide, and studies have shown that non-coding RNAs play a significant role in their development. Small nucleolar RNAs are a novel species of ncRNAs that may regulate different illnesses, including CVDs. Understanding the molecular processes and signaling pathways of snoRNAs in relation to CVDs is essential for further research and potential clinical applications.
FRONTIERS IN CELL AND DEVELOPMENTAL BIOLOGY
(2023)
Review
Medicine, Research & Experimental
Siarhei A. Dabravolski, Alexander M. Markin, Elena R. Andreeva, Ilya I. Eremin, Alexander N. Orekhov, Alexandra A. Melnichenko
Summary: Pericytes play crucial roles in the formation, maintenance, and regulation of blood vessels in cardiovascular diseases. They have been studied for their potential application in cell therapy and as pharmacological targets for novel drugs and techniques.
BIOMEDICINE & PHARMACOTHERAPY
(2022)
Review
Biochemistry & Molecular Biology
Leticia Gonzalez, Katherine Rivera, Marcelo E. Andia, Gonzalo Martinez Rodriguez
Summary: The IL-1 superfamily of cytokines, consisting of 11 cytokines and 10 receptors, is a crucial regulator of immunity and inflammation. It is tightly regulated through decoy receptor, receptor antagonists, and signaling inhibitors. Inflammation plays a central role in the development of atherosclerosis, and studies have shown the involvement of IL-1 cytokines and receptors in cardiovascular disease pathogenesis.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2023)
Review
Biochemistry & Molecular Biology
Darren Mehay, Yuval Silberman, Amy C. Arnold
Summary: Obesity is a chronic state of energy imbalance that poses a major public health problem, leading to increased risk for hypertension, hyperglycemia, and metabolic syndrome. While the mechanisms and optimal treatment strategies for obesity are not fully understood, activating central neurocircuits may be key in finding new anti-obesity drugs.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2021)
Review
Immunology
Wang-Dong Xu, Qi Huang, An-Fang Huang
Summary: The galectin family is a group of glycan-binding proteins playing important regulatory roles in a wide range of cellular and pathophysiological functions. Abnormal expression of galectins is associated with many inflammatory autoimmune diseases, mainly acting as disease regulators through binding to glycoconjugates.
AUTOIMMUNITY REVIEWS
(2021)
Article
Biology
Katharina Hutter, Silke E. Lindner, Constanze Kurschat, Thomas Ruelicke, Andreas Villunger, Sebastian Herzog
Summary: MiRNAs are small noncoding RNAs that regulate diverse physiological and pathological processes. The miR-26 family has been identified to play a role in early B cell development. Enhanced expression of miR-26 family members blocks the transition from pre-B to immature B cells, promotes pre-B cell expansion, and enables growth factor independency. This is at least partially mediated by repression of the tumor-suppressor Pten and subsequent enhancement of PI3K-AKT signaling.
LIFE SCIENCE ALLIANCE
(2022)
Review
Endocrinology & Metabolism
Sravya Jannapureddy, Mira Sharma, Gautham Yepuri, Ann Marie Schmidt, Ravichandran Ramasamy
Summary: Diabetes is a major risk factor for cardiovascular disease, and specific disease-modifying therapies are needed for diabetic patients. Research focusing on inhibiting the aldose reductase (AR) pathway to protect the cardiovascular system and the genetic polymorphisms associated with diabetic complications is ongoing to better understand and treat the consequences of diabetic cardiovascular disease.
FRONTIERS IN ENDOCRINOLOGY
(2021)
Review
Biochemistry & Molecular Biology
Panagiotis D. Papadopoulos, Christina Tsigalou, Pipitsa N. Valsamaki, Theocharis G. Konstantinidis, Chrysoula Voidarou, Eugenia Bezirtzoglou
Summary: The collection of normal microorganisms in our gut plays a significant role in our health, while dysbiosis in the gut microbial pool has been proven to be crucial in the pathophysiology of various diseases, including cardiovascular disease. In addition to traditional risk factors, research has also highlighted the involvement of gut bacteria and their metabolites in the pathogenesis of CVD.
Review
Hematology
Ana B. Arroyo, Sonia aguila, Maria P. Fernandez-Perez, Ascension M. de los Reyes-Garcia, Laura Reguilon-Gallego, Laura Zapata-Martinez, Vicente Vicente, Constantino Martinez, Rocio Gonzalez-Conejero
Summary: Thromboinflammation is a new concept that describes the interplay between thrombosis and inflammation, where antimicrobial structures formed in response to pathogens lead to deleterious effects like thrombotic complications. MiR-146a, an important miRNA, plays a key regulatory role in inflammation, particularly in modulating the Toll-like receptors/nuclear factor-kappa B axis.
THROMBOSIS AND HAEMOSTASIS
(2021)
Review
Cell Biology
Qi Shang, Gengyang Shen, Guifeng Chen, Zhida Zhang, Xiang Yu, Wenhua Zhao, Peng Zhang, Honglin Chen, Kai Tang, Fuyong Yu, Jingjing Tang, De Liang, Xiaobing Jiang, Hui Ren
Summary: miR-128 is involved in cell proliferation, differentiation, migration, apoptosis, and survival, with implications in bone metabolism and muscle regeneration. Dysregulation of miR-128 may lead to musculoskeletal diseases. Research on miR-128 presents significant therapeutic potential and suggests future research directions.
JOURNAL OF CELLULAR PHYSIOLOGY
(2021)
Review
Chemistry, Multidisciplinary
Lin Ru, Xiao-mei Wang, Jun-qi Niu
Summary: Non-alcoholic fatty liver disease (NAFLD) is increasingly prevalent globally, progressing from non-alcoholic fatty liver to hepatocellular carcinoma. The miR-23-27-24 cluster plays a significant role in the pathogenesis of NAFLD.
ACTA PHARMACOLOGICA SINICA
(2022)
Article
Biology
Dafeng Yang, Stefan Haemmig, Haoyang Zhou, Daniel Perez-Cremades, Xinghui Sun, Lei Chen, Jie Li, Jorge Haneo-Mejia, Tianlun Yang, Ivana Hollan, Mark W. Feinberg
Summary: The study shows that MTX and its metabolite adenosine exert anti-inflammatory effects in vascular endothelium by targeting and activating Mir181b expression. Specifically, MTX can attenuate inflammation and EC activation in a Mir181a2b2-dependent manner, indicating a potential therapeutic opportunity for anti-inflammatory therapy.
Article
Chemistry, Multidisciplinary
Yin Cai, Yu Zhang, Hui Chen, Xing-hui Sun, Peng Zhang, Lu Zhang, Meng-yang Liao, Fang Zhang, Zheng-yuan Xia, Ricky Ying-keung Man, Mark W. Feinberg, Susan Wai-Sum Leung
Summary: miR-17-3p inhibits LPS-induced NF-kappa B activation by targeting NIBP, thereby effectively suppressing pro-inflammatory responses in vascular endothelium.
ACTA PHARMACOLOGICA SINICA
(2021)
Article
Hematology
Stefan Haemmig, Ali Hashemi Gheinani, Marina Zaromytidou, Gerasimos Siasos, Ahmet Umit Coskun, Michelle A. Cormier, David A. Gross, A. K. M. Khyrul Wara, Antonios P. Antoniadis, Xinghui Sun, Galina K. Sukhova, Fred G. P. Welt, Ioannis Andreou, Carl Whatling, Li-Ming Gan, Johannes Wikstrom, Elazer R. Edelman, Peter Libby, Peter H. Stone, Mark W. Feinberg
Summary: This study identified evolutionarily conserved gene signatures and signaling pathways that distinguish diabetes-related and non-diabetes-related atherosclerosis. By utilizing genome-wide transcriptomics, the research successfully differentiated between atherosclerosis associated with diabetes and that not associated with diabetes, providing new insights and therapeutic opportunities.
ARTERIOSCLEROSIS THROMBOSIS AND VASCULAR BIOLOGY
(2021)
Article
Hematology
Jonathan D. Newman, MacIntosh G. Cornwell, Hua Zhou, Caron Rockman, Adriana Heguy, Yajaira Suarez, Henry S. Cheng, Mark W. Feinberg, Judith S. Hochman, Kelly Ruggles, Jeffrey S. Berger
Summary: A transcriptomic signature identified patients with symptomatic PAD and those at increased risk of major adverse cardiac or limb events (MACLE). A specific microRNA, microRNA-4477b, was found to be overexpressed in prevalent PAD, incident MACLE, and in a mouse hindlimb ischemia model. This novel signature provides insights into potential mechanisms of severe symptomatic PAD.
ARTERIOSCLEROSIS THROMBOSIS AND VASCULAR BIOLOGY
(2021)
Article
Biochemistry & Molecular Biology
Dakota Becker-Greene, Hao Li, Daniel Perez-Cremades, Winona Wu, Furkan Bestepe, Denizhan Ozdemir, Carolyn E. Niosi, Ceren Aydogan, Dennis P. Orgill, Mark W. Feinberg, Basak Icli
Summary: The study identified miR-409-3p as a critical regulator of EC-BAT crosstalk by modulating a ZEB1-MAP4K3-PLGF signaling axis, resulting in improved BAT angiogenesis, glucose tolerance, and energy expenditure in mice with diet-induced obesity.
CELLULAR AND MOLECULAR LIFE SCIENCES
(2021)
Article
Cardiac & Cardiovascular Systems
Daniel Perez-Cremades, Jingshu Chen, Carmel Assa, Mark W. Feinberg
Summary: Diabetes mellitus is a global public health problem that is expected to continue increasing due to the rise in obesity and aging population. Individuals with diabetes have a higher risk of cardiovascular complications, particularly myocardial infarction (MI). In the past two decades, studies have revealed the role of stage-specific miRNAs in the hearts of people with diabetes and MI, impacting cardiomyocyte death, angiogenesis, inflammatory response, myocardial remodeling, and myocardial lipotoxicity. Understanding the significance of these miRNAs and their targets may lead to novel RNA-based therapeutic interventions for managing the increased risk of MI in diabetes.
TRENDS IN CARDIOVASCULAR MEDICINE
(2023)
Article
Medicine, Research & Experimental
David A. Gross, Henry S. Cheng, Rulin Zhuang, Michael G. McCoy, Daniel Perez-Cremades, Zachary Salyers, A. K. M. Khyrul Wara, Stefan Haemmig, Terence E. Ryan, Mark W. Feinberg
Summary: SNHG12 is a dysregulated long noncoding RNA (lncRNA) in atherosclerosis, and it plays a significant role in the regulation of vascular senescence and angiogenic response. The deficiency of SNHG12 reduces cell proliferation, migration, and endothelial sprouting, while overexpression promotes these angiogenic functions. SNHG12 may exert its effects through interacting with proteins like IGF2BP3, and it is involved in cell cycle regulation and signaling pathways related to Wnt, Notch, and angiopoietin signaling pathways.
Article
Cardiac & Cardiovascular Systems
Jingshu Chen, Rulin Zhuang, Henry S. Cheng, Anurag Jamaiyar, Carmel Assa, Michael McCoy, Shruti Rawal, Daniel Perez-Cremades, Mark W. Feinberg
Summary: A new method for isolating and culturing diverse cell types from the mouse aorta simultaneously has been developed, allowing for the extraction of highly pure cells for studying the function and mechanisms of various vascular diseases.
Article
Cardiac & Cardiovascular Systems
Dafeng Yang, Stefan Haemmig, Jingshu Chen, Michael McCoy, Henry S. Cheng, Haoyang Zhou, Xiao Cheng, Xinghui Sun, Jorge Haneo-Mejia, Shamsudheen K. Vellarikkal, Rajat M. Gupta, Victor Barrera, Mark W. Feinberg
Summary: In this study, the researchers investigated the role of miRNA deficiency in vascular endothelial cells during atherogenesis using a mouse model. They found that the specific deletion of miR-181a2b2 in endothelial cells promoted atherosclerotic lesion formation, cell adhesion molecule expression, and the influx of macrophages in the vessel wall. However, the deletion of miR-181a2b2 did not affect body weight, lipid metabolism, or inflammation levels in circulating peripheral blood mononuclear cells. The study suggests that miR-181a2b2 deficiency in endothelial cells plays a crucial role in regulating key pathways involved in endothelial inflammation and atherosclerosis development.
Article
Cardiac & Cardiovascular Systems
Rulin Zhuang, Jingshu Chen, Henry S. Cheng, Carmel Assa, Anurag Jamaiyar, Arvind K. Pandey, Daniel Perez-Cremades, Bofang Zhang, Aspasia Tzani, Akm Khyrul Wara, Jorge Plutzky, Victor Barrera, Preetida Bhetariya, Richard N. Mitchell, Zhongmin Liu, Mark W. Feinberg
Summary: Transcription factor KLF10 is upregulated in CD4+ T cells of hypertensive individuals and Ang II-treated mice. Deficiency of Klf10 exacerbates perivascular fibrosis and multi-organ dysfunction in response to Ang II. Klf10 or IL-9 may represent novel therapeutic targets for the treatment of vascular or fibrotic diseases.
CIRCULATION RESEARCH
(2022)
Article
Biochemistry & Molecular Biology
Michael G. McCoy, Daniel Perez-Cremades, Nathan Belkin, Wenhui Peng, Bofang Zhang, Jingshu Chen, Madhur Sachan, A. K. M. Khyrul Wara, Rulin Zhuang, Henry S. Cheng, Mark W. Feinberg
Summary: This study demonstrates that a 4-miRNA cassette can reprogram vascular smooth muscle cells into endothelial cells, and these induced cells exhibit high similarity to native endothelial cells. Injected induced cells even restore blood flow faster than conventional endothelial cells in a mouse model, suggesting the potential of this approach for vascular disease therapy.
Article
Biochemistry & Molecular Biology
Haoyang Zhou, Dafeng Yang, Henry S. Cheng, Michael G. McCoy, Daniel Perez-Cremades, Stefan Haemmig, Danny Wong, Lei Chen, Mark W. Feinberg
Summary: The study uncovers an important role of miR-181b in regulating vascular endothelial aging through the MAP3K3-MAPK signaling pathway, revealing potential therapeutic targets for anti-aging therapy in cardiovascular disease.
Article
Multidisciplinary Sciences
Thao H. P. Nguyen, Ingrid Hokstad, Morten Wang Fagerland, Tom Eirik Mollnes, Ivana Hollan, Mark W. Feinberg, Gunnbjorg Hjeltnes, Gro O. Eilertsen, Knut Mikkelsen, Stefan Agewall
Summary: This study found that patients with active RA had elevated levels of complement activation, and TCC levels decreased after anti-rheumatic treatment within 6 weeks, but only TNFi +/- MTX treatment led to sustained reduction in TCC during the 6-month follow-up period. RA patients with endothelial dysfunction had higher baseline TCC compared to those without, indicating the potential involvement of complement in the atherosclerotic process in RA.
Article
Peripheral Vascular Disease
Michael G. McCoy, Anurag Jamaiyar, Grasiele Sausen, Henry S. Cheng, Daniel Perez-Cremades, Rulin Zhuang, Jingshu Chen, Philip P. Goodney, Mark A. Creager, Marc S. Sabatine, Marc P. Bonaca, Mark W. Feinberg
Summary: Peripheral artery disease (PAD) is a serious condition that can lead to limb loss and death, especially in subjects with diabetes. In this study, researchers identified miR-375 as a potential therapeutic target for critical limb ischemia (CLI), an advanced form of PAD. They found that miR-375, when overexpressed, promotes angiogenesis and arteriogenesis, improving blood flow recovery in diabetic mice. Further investigation revealed that miR-375 regulates the NF-kB signaling pathway by targeting Kruppel-like factor 5 (KLF5). These findings suggest that targeting the miR-375-KLF5-NF-kB signaling axis may be an effective strategy for treating CLI in diabetes.
Article
Cardiac & Cardiovascular Systems
Akm Khyrul Wara, Shruti Rawal, Xilan Yang, Daniel Perez-Cremades, Madhur Sachan, Jingshu Chen, Mark W. Feinberg
Summary: This study identifies a critical role for the transcription factor KLF10 in regulating the interactions between CD4+ Tregs and macrophages in atherosclerosis. Knockout of KLF10 in CD4+ T cells leads to exaggerated plaque progression due to defects in the immunosuppressive functions of Tregs on macrophages. Adoptive cellular therapy with WT Tregs reverses the accelerated lesion progression and deleterious effects in KLF10 knockout mice.