Review
Biochemistry & Molecular Biology
Pavel P. Tregub, Irada Ibrahimli, Anton S. Averchuk, Alla B. Salmina, Peter F. Litvitskiy, Zaripat Sh. Manasova, Inga A. Popova
Summary: In recent times, there has been a growing interest among researchers in understanding the functions of microRNAs and their role in the development of various diseases. This review analyzes existing scientific data on the involvement of microRNAs in the molecular and cellular mechanisms underlying Alzheimer's disease, cerebral ischemia and reperfusion injury, and blood-brain barrier dysfunction.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2023)
Review
Biochemistry & Molecular Biology
Pengfang Sun, Huilin Wang, Pan Zhao, Qiulin Yu, Yumei He, Wenhong Deng, Huihong Guo
Summary: This review focuses on the regulatory roles of widely studied HD-ZIP, MYB, and NAC transcription factor gene families in xylem development, as well as the regulation of their upstream microRNAs. The existing questions in the research and future research directions are also prospected.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2022)
Article
Fisheries
Wei Zhou, Yadong Xie, Yu Li, Mingxu Xie, Zhen Zhang, Yalin Yang, Zhigang Zhou, Ming Duan, Chao Ran
Summary: miRNAs are a class of highly conserved, small non-coding RNA molecules with a length of 18-25 nucleotides that negatively regulate target genes through complementary pairing with mRNA. Recent research has shown that miRNAs play important roles in regulating fish nutrition and immunity, including influencing fatty acid synthesis and involvement in antibacterial and antiviral immune responses.
FISH & SHELLFISH IMMUNOLOGY
(2021)
Review
Dentistry, Oral Surgery & Medicine
Pamela Gehron Robey, Bruce J. Baum
Summary: Marie Ussing Nylen was a trailblazing scientist and administrative leader at the US National Institutes of Health, achieving success at a time when it was particularly challenging for women. She was not only a gifted professional but also a well-rounded individual, excelling in various aspects of life.
Article
Dentistry, Oral Surgery & Medicine
B. He, V. Kram, T. Furusawa, O. Duverger, E. Y. Chu, R. Nanduri, M. Ishikawa, P. Zhang, B. A. Amendt, J. S. Lee, M. Bustin
Summary: The study suggests that HMGN proteins play a role in regulating ameloblast differentiation and enamel mineralization by modulating lineage-specific chromatin accessibility and transcription factor binding to ameloblast regulatory sites. The absence of HMGN proteins in mice leads to faster ameloblast differentiation and increased enamel deposition rate in molars and incisors.
JOURNAL OF DENTAL RESEARCH
(2023)
Review
Biology
Il-Kwon Kim, Byeong-Wook Song, Soyeon Lim, Sang-Woo Kim, Seahyoung Lee
Summary: Cardiovascular diseases are the leading cause of death worldwide, and obesity is a known risk factor. Epicardial adipose tissue has been identified as an important factor in the development of cardiovascular disease. This review summarizes differentially expressed miRNAs in human epicardial adipose tissue under pathologic conditions, focusing on their targets and roles in tissue regulation. The study suggests that epicardial adipose tissue-derived miRNAs have potential diagnostic and therapeutic applications in cardiovascular diseases, but further research is needed to understand their overall impact and potential risks.
Article
Plant Sciences
Shivani Kansal, Vaishali Panwar, Roseeta Devi Mutum, Saurabh Raghuvanshi
Summary: This study demonstrates the active involvement of [Ca2+](cyt) in regulating the expression of miRNA genes in rice, especially under stress conditions. Calmodulins and Calmodulin-binding Transcription Activators are identified as crucial components of the signal transduction schema that regulates miRNA expression.
FRONTIERS IN PLANT SCIENCE
(2021)
Review
Pharmacology & Pharmacy
Zeeshan Javed, Khushbukhat Khan, Amna Rasheed, Haleema Sadia, Shahid Raza, Bahare Salehi, William C. Cho, Javad Sharifi-Rad, Wojciech Koch, Wirginia Kukula-Koch, Anna Glowniak-Lipa, Pawel Helon
Summary: Prostate cancer is a complex anomaly with rising incidence in the global male population, involving intricate cellular processes and key signaling pathways such as Transforming Growth Factor-beta (TGF-beta). MicroRNAs play a crucial role in regulating TGF-beta signaling, influencing cancer progression. Natural compounds, known for their high efficacy and low cytotoxicity, are being researched for the development of new therapeutic options for PCa.
FRONTIERS IN PHARMACOLOGY
(2021)
Article
Cell Biology
Patricia Corrales, Marina Martin-Taboada, Yurena Vivas-Garcia, Lucia Torres, Laura Ramirez-Jimenez, Yamila Lopez, Daniel Horrillo, Rocio Vila-Bedmar, Eloisa Barber-Cano, Adriana Izquierdo-Lahuerta, Maria Pena-Chilet, Carmen Martinez, Joaquin Dopazo, Manuel Ros, Gema Medina-Gomez
Summary: Caloric restriction is a non-pharmacological intervention that improves metabolic defects associated with aging. MiRNA expression levels can serve as predictive tools for aging-related alterations. Specific miRNAs contribute to impaired insulin-stimulated glucose metabolism in subcutaneous white adipose tissue, and their expression is modified by caloric restriction, suggesting their potential as biomarkers for age-related metabolic alterations.
Review
Plant Sciences
Baoyu Ji, Liangshuang Xuan, Yunxiang Zhang, Guoqi Zhang, Jie Meng, Wenrong Mu, Jingjing Liu, Kee-Yoeup Paek, So-Young Park, Juan Wang, Wenyuan Gao
Summary: This review focuses on the biotechnological research of Astragalus membranaceus, including tissue culture, metabolic regulation of chemical compounds, and the synthetic biology of astragalosides. It aims to provide a broader development prospect for the in-depth study of medicinal plants.
Article
Allergy
Ping-Ping Cao, Bao-Feng Wang, James E. Norton, Lydia A. Suh, Roderick G. Carter, Whitney W. Stevens, Anna G. Staudacher, Julia H. Huang, Kathryn E. Hulse, Anju T. Peters, Leslie C. Grammer, David B. Conley, Kevin C. Welch, Robert C. Kern, Zheng Liu, Jingying Ye, Robert P. Schleimer
Summary: This study investigated the mechanisms and activation pathways of coagulation cascade in chronic rhinosinusitis with nasal polyps (CRSwNP). The results showed increased activation of coagulation cascade, local production of tissue factor (TF) and activated factor VII (FVII) in sinonasal mucosa, and reduced formation of the complex of activated factor X (FXa) and TF pathway inhibitor (TFPI) in nasal polyp tissue. These findings suggest that the extrinsic coagulation pathway may play a role in promoting fibrin deposition in CRSwNP.
JOURNAL OF ALLERGY AND CLINICAL IMMUNOLOGY
(2022)
Review
Biochemistry & Molecular Biology
Yaashini Rajasegaran, Adam Azlan, Aliaa Arina Rosli, Mot Yee Yik, Khor Kang Zi, Narazah Mohd Yusoff, Emmanuel Jairaj Moses
Summary: MicroRNAs play a crucial role in cancer by regulating various cancer hallmarks such as proliferation, invasion, and metastasis. Understanding the mechanisms of miRNA regulation in different cancer hallmarks can provide insights for utilizing microRNAs as biomarkers and therapeutic targets in cancer research.
Article
Hematology
Hari Hara Sudhan Lakshmanan, Aldrich Estonilo, Stephanie E. Reitsma, Alexander R. Melrose, Jayaram Subramanian, Tony J. Zheng, Jeevan Maddala, Erik Tucker, David Gailani, Owen J. T. McCarty, Patrick L. Jurney, Cristina Puy
Summary: This study evaluated the contribution of feedback activation of coagulation factor XI (FXI) in TF-mediated thrombin generation using a comprehensive systems-based analysis. The results showed that the feedback activation of FXI contributes to the propagation of thrombin generation based on the initial concentrations of TF or activated coagulation factor X (FXa). Additionally, it was predicted and experimentally validated that the inhibitory function of tissue factor pathway inhibitor (TFPI) can abolish the positive feedback of FXI activation by thrombin.
JOURNAL OF THROMBOSIS AND HAEMOSTASIS
(2022)
Review
Neurosciences
Jonathan G. Hanley
Summary: AMPA receptors play a critical role in synaptic transmission and brain function, with their expression at synapses determining functional connectivity of neuronal circuits and underpinning learning and memory. Dysregulation of excitatory synaptic transmission and plasticity processes is involved in various neurological disorders. MiRNAs play a role in regulating AMPAR subunit expression and synaptic plasticity, potentially contributing to both physiological and pathological changes in the brain.
Article
Endocrinology & Metabolism
Yao Xie, Yongli Ji, Yunrui Lu, Yuankun Ma, Hui Ni, Jian Shen, Hong Ma, Chunna Jin, Yuwen Chen, Yan Lin, Meixiang Xiang
Summary: This study used single-cell analysis to compare the heterogeneity, functions, and cell fates of subcutaneous adipose-derived stem cells (SUB-ADSCs) and perivascular ADSCs (PV-ADSCs). Four subpopulations of PV-ADSCs were identified, with the Clec11a+ subpopulation potentially regulating the differentiation of PV-ADSCs towards a smooth muscle cell phenotype. The study revealed distinct characteristics between PV-ADSCs and SUB-ADSCs.
Article
Pharmacology & Pharmacy
Ulrike Leppert, Allan Gillespie, Miriam Orphal, Karen Boehme, Claudia Plum, Kaj Nagorsen, Janine Berkholz, Reinhold Kreutz, Andreas Eisenreich
EUROPEAN JOURNAL OF PHARMACOLOGY
(2017)
Article
Biology
Angela Schulz, Nicola Victoria Mueller, Nina Anne van de Lest, Andreas Eisenreich, Martina Schmidbauer, Andrei Barysenka, Bettina Purfuerst, Anje Sporbert, Theodor Lorenzen, Alexander M. Meyer, Laura Herlan, Anika Witten, Frank Ruehle, Weibin Zhou, Emile de Heer, Marion Scharpfenecker, Daniela Panakova, Monika Stoll, Reinhold Kreutz
Review
Chemistry, Applied
Andreas Eisenreich, Benjamin Sachse, Rainer Guertler, Birgit Dusemund, Oliver Lindtner, Bernd Schaefer
Review
Chemistry, Applied
Andreas Eisenreich, Rainer Guertler, Bernd Schaefer
Article
Medicine, Research & Experimental
Andreas Eisenreich, Miriam Orphal, Karen Boehme, Reinhold Kreutz
Article
Physiology
Miriam Orphal, Allan Gillespie, Karen Boehme, Jana Subrova, Andreas Eisenreich, Reinhold Kreutz
KIDNEY & BLOOD PRESSURE RESEARCH
(2020)
Review
Food Science & Technology
Andreas Eisenreich, Mario E. Goetz, Benjamin Sachse, Bernhard H. Monien, Kristin Herrmann, Bernd Schaefer
Summary: Alkenylbenzenes are natural secondary plant metabolites primarily found in herbs and spices; compounds like safrole and methyleugenol have genotoxic and carcinogenic effects, while the toxicological relevance of other alkenylbenzenes remains uncertain. Further research is needed to fully understand the potential adverse effects of alkenylbenzenes on human health.
Article
Peripheral Vascular Disease
Katja Grabowski, Laura Herlan, Anika Witten, Fatimunnisa Qadri, Andreas Eisenreich, Diana Lindner, Martin Schaedlich, Angela Schulz, Jana Subrova, Ketaki Nitin Mhatre, Uwe Primessnig, Ralph Plehm, Sophie van Linthout, Felicitas Escher, Michael Bader, Monika Stoll, Dirk Westermann, Frank R. Heinzel, Reinhold Kreutz
Summary: Through genetic models and mouse experiments, the study identified the importance of Cpxm2 in hypertension-mediated left ventricular hypertrophy and cardiac damage, and showed that the absence of Cpxm2 can effectively reduce these injuries.
HYPERTENSION RESEARCH
(2022)
Article
Biochemistry & Molecular Biology
Rusan Catar, Melanie Herse-Naether, Nan Zhu, Philine Wagner, Oskar Wischnewski, Angelika Kusch, Julian Kamhieh-Milz, Andreas Eisenreich, Ursula Rauch, Bjoern Hegner, Harald Heidecke, Angela Kill, Gabriela Riemekasten, Gunnar Kleinau, Patrick Scheerer, Duska Dragun, Aurelie Philippe
Summary: Scleroderma renal crisis is a severe complication of systemic sclerosis, characterized by vascular obstruction and thrombotic microangiopathy. The study suggests that patient-derived antibodies can trigger endothelial cell proliferation and affect cellular activities through various signaling pathways.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2022)
Article
Biochemistry & Molecular Biology
Jana Subrova, Karen Boehme, Allan Gillespie, Miriam Orphal, Claudia Plum, Reinhold Kreutz, Andreas Eisenreich
Summary: This study found that miRNA-29b and miRNA-497 can directly regulate the posttranscriptional expression of CPXM2 in rat cardiomyocytes by binding to the 3' UTR of CPXM2 mRNA.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2022)
Review
Food Science & Technology
Mario E. Goetz, Benjamin Sachse, Bernd Schaefer, Andreas Eisenreich
Summary: Alkenylbenzenes are naturally occurring substances found in various plants, including nutmeg and basil, and are commonly used as flavorings. However, many alkenylbenzenes are known to be toxic, with some being genotoxic carcinogens. There is limited toxicological data available for certain alkenylbenzenes, such as myristicin and elemicin, and existing data on their occurrence in foods is also limited. This lack of data makes it difficult to evaluate the health risks associated with these substances.
Review
Chemistry, Applied
Andreas Eisenreich, Bernhard H. Monien, Mario E. Goetz, Thorsten Buhrke, Axel Oberemm, Katharina Schultrich, Klaus Abraham, Albert Braeuning, Bernd Schaefer
Summary: This article summarizes the current knowledge on 3-MCPD and its fatty acid esters (FE), focusing on pending issues related to exposure assessment using biomarkers and the identification of (toxic) metabolites formed after exposure to FE of 3-MCPD and their modes of action.
Editorial Material
Food Science & Technology
Andreas Eisenreich, Bernd Schaefer
Review
Plant Sciences
Mario E. Goetz, Andreas Eisenreich, Janine Frenzel, Benjamin Sachse, Bernd Schaefer
Summary: Alkenylbenzenes are natural secondary plant metabolites, some of which are proven genotoxic carcinogens. This review provides an overview of the occurrence of potentially toxic alkenylbenzenes in essential oils and extracts used for flavoring purposes in food. It focuses on well-known genotoxic alkenylbenzenes like safrole, methyleugenol, and estragole, but also considers other alkenylbenzenes commonly used for flavoring. The review emphasizes the need for quantitative occurrence data on alkenylbenzenes in plants and final plant food supplements, processed foods, and flavored beverages for more reliable exposure assessment in the future.
Review
Biochemistry & Molecular Biology
Andreas Eisenreich, Ulrike Leppert
CURRENT MEDICINAL CHEMISTRY
(2017)
