Article
Pharmacology & Pharmacy
Shiru Bai, Xuechao Wang, Haibo Wu, Tianlei Chen, Xinning Li, Lina Zhang, Xiangming Li, Lu Er, Rongpin Du
Summary: The study demonstrated that anisodamine could protect against myocardial ischemia/reperfusion injury by improving mitochondrial energy metabolism, reducing oxidative stress, and stabilizing mitochondrial membrane potential. The opening of mitoK ATP may play a crucial role in the cardioprotective effects of anisodamine.
EUROPEAN JOURNAL OF PHARMACOLOGY
(2021)
Article
Biology
Sarah K. El-Meanawy, Holly Dooge, Allison C. Wexler, Anna C. Kosmach, Lara Serban, Elizabeth A. Santos, Francisco J. Alvarado, Timothy A. Hacker, Mohun Ramratnam
Summary: The mitochondrial splice variant of the sulfonylurea receptor (SUR2A-55) is associated with protection from myocardial ischemia-reperfusion (IR) injury, increased mitochondrial ATP sensitive K+ channel activity (mitoK(ATP)) and altered glucose metabolism. It was found that SUR2A-55 regulates ROMK to form an alternate mitoK(ATP). The cardio-protection from SUR2A-55 is associated with ROMK regulation, enhanced mitochondrial uncoupling, and increased glucose uptake.
Article
Pharmacology & Pharmacy
Abigail R. Bland, Fergus M. Payne, John C. Ashton, Tannaz Jamialahmadi, Amirhossein Sahebkar
Summary: During cardiac reperfusion after myocardial infarction, the heart faces ischaemia reperfusion injury (IRI) which leads to myocardial dysfunction and cell death. Research has identified potential targeted therapies focusing on mitochondria, such as opening of the mitochondrial permeability transition pore, activation of mitoK(ATP) channels, and inhibition of GSK3 beta phosphorylation, to reduce the severity of myocardial IRI. Additionally, statins have shown direct cardioprotective effects on specific mitochondrial components, indicating their potential as a preconditioning agent.
PHARMACOLOGICAL RESEARCH
(2022)
Article
Multidisciplinary Sciences
Zhongyang Xu, Xiaoqi Wang, Lijiao Zang, Lei Wang, Guohai Su, Keqing Hu
Summary: This study demonstrates the significant protective effects of combined therapy with irisin and melatonin on cardiac I/R injury in aged rats. The protective effects are mediated in part by the activation of mitoKATP channels and the eNOS/NO signaling pathway.
JOURNAL OF KING SAUD UNIVERSITY SCIENCE
(2022)
Article
Pharmacology & Pharmacy
Plinio Bezerra Palacio, Aline Maria Brito Lucas, Joana Varlla de Lacerda Alexandre, Pedro Lourenzo Oliveira Cunha, Yuana Ivia Ponte Viana, Amanda Cabral Albuquerque, Anna Lidia Nunes Varela, Heberty Tarso Facundo
Summary: The study reveals competitive binding of glibenclamide and diazoxide at mitoSUR, with the cyclohexylurea portion of glibenclamide being essential for mitoKATP inhibition. IMP-A does not inhibit diazoxide-induced cardioprotection, but glibenclamide effectively inhibits it. This research provides valuable insights into the pharmacological and biochemical aspects of mitoKATP activation and cardioprotection, potentially leading to new therapeutic strategies for ischemia-reperfusion injury.
EUROPEAN JOURNAL OF PHARMACOLOGY
(2021)
Review
Pharmacology & Pharmacy
Rafal P. Kampa, Aleksandra Sek, Piotr Bednarczyk, Adam Szewczyk, Vincenzo Calderone, Lara Testai
Summary: Reduced coronary blood supply leads to cell death and loss of cardiomyocyte population, resulting in serious consequences on myocardial function. This review explores the potential of flavonoids as modulators of mitochondrial potassium channels (mitoK channels) for treating cardiovascular diseases, particularly myocardial infarction.
JOURNAL OF PHARMACY AND PHARMACOLOGY
(2023)
Review
Pharmacology & Pharmacy
Corrado De Marco, Thierry Charron, Guy Rousseau
Summary: Adenosine has the potential benefits in the treatment of acute myocardial infarction by inhibiting the pathophysiological processes leading to reperfusion injury. However, the heterogenous evidence regarding its effects has resulted in limited uptake in clinical practice. Therefore, studying the dose, route, timing, and site of administration of adenosine is crucial for its efficacy.
FRONTIERS IN PHARMACOLOGY
(2022)
Article
Medicine, Research & Experimental
Yaozu Li, Xiaotong Sun, Zhaodong Juan, Xuehao Guan, Mingling Wang, Yanmei Meng, Ruijin Ma
Summary: Propofol has a protective effect on myocardial ischemia-reperfusion (I/R) injury by inhibiting mast cell degranulation and calcium influx through store-operated Ca2+ channels (SOCs).
BIOMEDICINE & PHARMACOTHERAPY
(2022)
Article
Plant Sciences
Sihan Hu, Lan Jiang, Qi Yan, Chenyang Zhou, Xiaochuan Guo, Tong Chen, Siting Ma, Yimiao Luo, Caiyu Hu, Fumin Yang, Lishan Yuan, Xiao Ma, Jinhao Zeng
Summary: Baicalin exhibits positive effects on myocardial ischemia diseases, achieved by regulating key pathological indicators and various signaling pathways. In animal models of myocardial ischemia, reperfusion injury, and myocardial infarction, baicalin can reduce myocardial infarction size, improve cardiac pathological condition, and enhance heart function indicators.
Article
Pharmacology & Pharmacy
Alex Gallinat, Guiomar Mendieta, Gemma Vilahur, Teresa Padro, Lina Badimon
Summary: Cardiovascular diseases, especially acute myocardial infarction (MI), are major causes of death worldwide. DJ-1 protein has been found to play a crucial role in cardioprotection, and systemic administration of recombinant DJ-1 has been shown to reduce infarct size, leukocyte infiltration, apoptosis, and oxidative stress in a mouse model of MI. These effects may be mediated by G-protein-coupled receptor signaling and modulation of immune response. This study provides the first evidence for the extracellular activity of DJ-1 in regulating cardiac injury in vivo.
FRONTIERS IN PHARMACOLOGY
(2022)
Review
Pharmacology & Pharmacy
Zhicheng Wang, Weikang Bian, Yufeng Yan, Dai-Min Zhang
Summary: ATP-sensitive potassium channels (K-ATP channels) play important roles in cellular excitability and metabolism. Activation of K-ATP channels can repolarize the membrane potential and reduce the occurrence of arrhythmias. Under severe and prolonged anoxia, K-ATP channels open to decrease cellular excitability and prevent action potential generation. Small active molecules can enhance the opening of K-ATP channels, leading to membrane repolarization and decreased malignant arrhythmias. Mutations in K-ATP channels worsen the regulatory roles in mutation-related diseases. However, efficient treatments for patients with K-ATP channel mutations are still lacking.
FRONTIERS IN PHARMACOLOGY
(2022)
Article
Medicine, General & Internal
Lidiia Mys, Yulia Goshovska, Nataliia Strutynska, Raisa Fedichkina, Yuliia Korkach, Ruslan Strutynskyi, Vadim Sagach
Summary: In old rats, administration of PLP increased the expression levels of CSE, 3-MST, UCP3, SUR2, and Kir6.1 genes, leading to higher H2S content, reduced oxidative stress, and prevented reperfusion dysfunction of the heart after ischemia.
EUROPEAN JOURNAL OF CLINICAL INVESTIGATION
(2022)
Article
Cell Biology
Min Liu, Cui Liu, Xue Xiao, Shuai-Shuai Han, Ming-Xia Bi, Qian Jiao, Xi Chen, Chun-Ling Yan, Xi-Xun Du, Hong Jiang
Summary: The upregulation of the SUR1 subunit in ATP-sensitive potassium channels is found to play an important role in the selective degeneration of dopaminergic neurons in Parkinson's disease. Delaying the progression of dopaminergic neuron degeneration is possible through interference with SUR1 expression. The elevated expression of transcription factors FOXA1 and FOXA2 has been identified as a mechanism causing the upregulation of the SUR1 subunit.
Article
Cardiac & Cardiovascular Systems
Liang Wang, Xuebai Lv, Jue Tian, Xiaoliang Wang, Ye Wu, Hui Rong Liu
Summary: The study found that Nec-1 may reduce myocardial cell death and maintain myocardial architectural integrity, thus inhibiting the reactive fibrosis process in rats during myocardial ischemia/late reperfusion. Administration of Nec-1 at the onset of reperfusion significantly reduced the release of creatine kinase and downregulated autophagy within 24 hours after reperfusion, with a significantly positive correlation between them.
CARDIOVASCULAR THERAPEUTICS
(2021)
Review
Biochemistry & Molecular Biology
Yevheniia Kravenska, Vanessa Checchetto, Ildiko Szabo
Summary: Potassium ions can enter and exit mitochondria through various channels in the outer and inner membranes, with the ATP-dependent potassium channel being the most studied and playing a crucial role in protecting cells against ischemic and neuronal damage.
Article
Multidisciplinary Sciences
Hua-Qian Yang, Wilnelly Martinez-Ortiz, JongIn Hwang, Xuexin Fan, Timothy J. Cardozo, William A. Coetzee
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA
(2020)
Article
Cardiac & Cardiovascular Systems
Chelsea L. Organ, Zhen Li, Thomas E. Sharp, David J. Polhemus, Nilaksh Gupta, Traci T. Goodchild, W. H. Wilson Tang, Stanley L. Hazen, David J. Lefer
JOURNAL OF THE AMERICAN HEART ASSOCIATION
(2020)
Article
Cardiac & Cardiovascular Systems
Ivan Gando, Chiara Campana, Reina Bianca Tan, Frank Cecchin, Eric A. Sobie, William A. Coetzee
JOURNAL OF MOLECULAR AND CELLULAR CARDIOLOGY
(2020)
Review
Physiology
Thomas E. Sharp, David J. Lefer
Summary: Heart failure is a global pandemic with challenges in treatment, particularly in patient tolerance to neurohormonal pharmacotherapies. Renal denervation as a novel therapeutic strategy provides a potential possibility to attenuate the progression of HF.
ANNUAL REVIEW OF PHYSIOLOGY, VOL 83
(2021)
Article
Cardiac & Cardiovascular Systems
Huijing Xia, Zhen Li, Thomas E. Sharp, David J. Polhemus, Jean Carnal, Karl H. Moles, Ya-Xiong Tao, John Elrod, Josef Pfeilschifter, Karl-Friedrich Beck, David J. Lefer
JOURNAL OF THE AMERICAN HEART ASSOCIATION
(2020)
Article
Immunology
Berk Aykut, Ruonan Chen, Jacqueline Kim, Dongling Wu, Sorin A. A. Shadaloey, Raquel Abengozar, Pamela Preiss, Anjana Saxena, Smruti Pushalkar, Joshua Leinwand, Brian Diskin, Wei Wang, Gregor Werba, Matthew Berman, Steve Ki Buom Lee, Alireza Khodadadi-Jamayran, Deepak Saxena, William A. Coetzee, George Miller
SCIENCE IMMUNOLOGY
(2020)
Editorial Material
Cardiac & Cardiovascular Systems
Zhen Li, David J. Lefer
CIRCULATION RESEARCH
(2021)
Review
Biochemistry & Molecular Biology
Kyle B. LaPenna, David J. Polhemus, Jake E. Doiron, Hunter A. Hidalgo, Zhen Li, David J. Lefer
Summary: Hydrogen sulfide (H2S) is an endogenous gaseous signaling molecule that plays a critical role in cardiac and vascular biology by regulating vascular tone, oxidant defenses, and exerting cytoprotective effects. Recent studies have shown that H2S modulates various components of metabolic syndrome and exhibits cardioprotective signaling in heart failure.
Review
Cell Biology
Hua-Qian Yang, Fabio A. Echeverry, Assmaa ElSheikh, Ivan Gando, Sophia Anez Arredondo, Natalie Samper, Timothy Cardozo, Mario Delmar, Show-Ling Shyng, William A. Coetzee
Summary: Sarcolemmal/plasmalemmal ATP-sensitive K+ (K-ATP) channels play crucial roles in various cell types and tissues. Recent studies have highlighted that the surface expression of K-ATP channels is tightly regulated and has significant implications in both health and disease.
AMERICAN JOURNAL OF PHYSIOLOGY-CELL PHYSIOLOGY
(2022)
Editorial Material
Cardiac & Cardiovascular Systems
Jake E. Doiron, David J. Lefer
CIRCULATION RESEARCH
(2022)
Article
Biochemistry & Molecular Biology
Eric Goetzman, Zhenwei Gong, Dhivyaa Rajasundaram, Ishan Muzumdar, Traci Goodchild, David Lefer, Radhika Muzumdar
Summary: Acute myocardial infarction is a leading cause of death worldwide. This study investigated the metabolic changes in serum during ischemia and reperfusion injury in a swine model, aiming to identify metabolomic biomarkers for myocardial injury at different phases. The results showed distinct profiles of serum metabolites during ischemia and early and late reperfusion, with impaired mitochondrial function and amino acid modifications during ischemia, and changes in branched-chain amino acid metabolites and bile acid pathway derivatives during reperfusion.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2022)
Article
Cell Biology
Erkan Tuncay, Ivan Gando, Jian-Yi Huo, Gautham Yepuri, Natalie Sampler, Belma Turan, Hua-Qian Yang, Ravichandran Ramasamy, William A. Coetzee
Summary: Sirtuins are beneficial NAD+-dependent deacetylases that play roles in various human health conditions. In this study, researchers investigated the regulation of ATP-sensitive K+ (KATP) channels by sirtuins. They found that increasing NAD+ levels and activating sirtuins led to an increase in KATP channel current and surface expression. This finding has implications for cardiac protection against ischemic damage.
AMERICAN JOURNAL OF PHYSIOLOGY-CELL PHYSIOLOGY
(2023)
Letter
Cardiac & Cardiovascular Systems
Thomas E. Sharp, David J. Lefer, Traci T. Goodchild
JACC-BASIC TO TRANSLATIONAL SCIENCE
(2021)
Article
Cardiac & Cardiovascular Systems
Thomas E. Sharp, Zhenwei Gong, Amy Scarborough, Eric S. Goetzman, Murtuza J. Ali, Pablo Spaletra, David J. Lefer, Radhika H. Muzumdar, Traci T. Goodchild
JACC-BASIC TO TRANSLATIONAL SCIENCE
(2020)
Article
Cardiac & Cardiovascular Systems
Thomas E. Sharp, Amy L. Scarborough, Zhen Li, David J. Polhemus, Hunter A. Hidalgo, Jeffery D. Schumacher, Timothy R. Matsuura, J. Stephen Jenkins, Daniel P. Kelly, Traci T. Goodchild, David J. Lefer
Summary: This study developed a novel large animal model of HFpEF that replicates the multiple comorbidities associated with human HFpEF, providing a valuable tool for investigating the pathogenesis of the disease and testing new therapeutic strategies.
JACC-BASIC TO TRANSLATIONAL SCIENCE
(2021)
